protein

GLUT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

317Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

5Debates

Summary

Page for GLUT1 Protein

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🔬 Protein Info

Gene Symbol	GLUT1
Aliases	Glucose Transporter 1
Function	GLUT1 (Glucose Transporter 1), encoded by the SLC2A1 gene, is the primary facilitative glucose transporter at the blood-brain barrier (BBB).
Molecular Weight	54.0 kDa
Pathways	autophagy pathway, blood-brain barrier, Glycolysis, Mtor, Oxidative Phosphorylation
GeneCards	GLUT1
Human Protein Atlas	GLUT1
Associated Diseases	ALS, Bladder Cancer, epilepsy, glioblastoma, multiple sclerosis, neurodegeneration
Known Drugs/Compounds	BAY-876
Interactions	ACC, ACLY, Actin, AKT, AMPK, AND
KG Connections	317 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GLUT1["GLUT1"]
    triple_negative_breast_cancer{"triple negative breast cancer"}
    GLUT1 -->|"associated with"| triple_negative_breast_cancer
    GLUT1 -->|"biomarker for"| triple_negative_breast_cancer
    PI3K_Akt_Pathway(["PI3K/Akt Pathway"])
    PI3K_Akt_Pathway -->|"phosphorylates"| GLUT1
    SLC2A1["SLC2A1"]
    SLC2A1 -->|"encodes"| GLUT1
    BAY_876["BAY-876"]
    BAY_876 -->|"inhibits"| GLUT1
    RB1["RB1"]
    RB1 -->|"interacts with"| GLUT1
    RB1 -->|"regulates"| GLUT1
    style GLUT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (237)

Target	Relation	Type	Str
High-Carbohydrate Diet	upregulates	drug	0.85
Lactate Shuttle	involved_in	mechanism	0.85
Bladder Cancer	associated_with	disease	0.85
Aerobic Glycolysis	upregulates	process	0.85
glycolysis	activates	pathway	0.80
Glycolytic Enzymes	regulates	enzyme	0.80
TNF-α	regulates	protein	0.80
triple negative breast cancer	associated_with	disease	0.70
triple negative breast cancer	biomarker_for	disease	0.70
autophagy pathway	participates_in	pathway	0.70
Retinopathy	inhibits	disease	0.65
blood-brain barrier	participates_in	pathway	0.65
Carcinoma	activates	disease	0.65
ALS	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Ms	regulates	disease	0.65
Ischemia	regulates	disease	0.65
Retinopathy	activates	disease	0.65
Diabetes	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Diabetes	inhibits	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	inhibits	disease	0.65
Dementia	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Inflammation	inhibits	disease	0.65
OXIDATIVE STRESS	treats	phenotype	0.65
Cancer	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
ALS	regulates	disease	0.65
Tumor	regulates	disease	0.65
Neuropathy	protects_against	disease	0.65
Als	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
GLIOBLASTOMA	regulates	gene	0.60
Lipid Metabolism	regulates	pathway	0.60
Cholesterol	regulates	pathway	0.60
AND	contributes_to	gene	0.60
GLUT3	contributes_to	gene	0.60
CANCER	inhibits	gene	0.60
SREBP2	regulates	gene	0.60

Incoming (80)

Source	Relation	Type	Str
PI3K/Akt Pathway	phosphorylates	pathway	0.90
Pi3K/Akt Pathway	phosphorylates	pathway	0.90
AKT	phosphorylates	protein	0.90
PI3K/AKT	phosphorylates	pathway	0.90
WIF1	downregulates	protein	0.85
Akt	phosphorylates	protein	0.80
BAY-876	inhibits	drug	0.70
RB1	interacts_with	protein	0.70
RB1	regulates	protein	0.70
SLC2A1	encodes	gene	0.70
WARBURG EFFECT	phosphorylates	phenotype	0.65
AND	activates	gene	0.60
C-MYC	activates	gene	0.60
HIF-1Α	activates	gene	0.60
PI3K	activates	gene	0.60
HIF-1Α	regulates	gene	0.60
LDHB	activates	gene	0.60
G6PD	activates	gene	0.60
GLUT3	activates	gene	0.60
LDHA	activates	gene	0.60
MYC	activates	gene	0.60
MICROGLIA	activates	gene	0.60
GBM	interacts_with	gene	0.60
AKT	expressed_in	gene	0.60
CD36	activates	gene	0.60
GBM	associated_with	gene	0.60
RNA	regulates	gene	0.60
EGFR	regulates	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TNF	inhibits	gene	0.60
GLS	activates	gene	0.60
IL-10	activates	gene	0.60
GBM	activates	gene	0.60
RNA	inhibits	gene	0.60
SREBP2	regulates	gene	0.60
ACC	activates	gene	0.60
ACLY	activates	gene	0.60
GENES	regulates	gene	0.60
RAB11	regulates	gene	0.60
AND	inhibits	gene	0.60
HIF	inhibits	gene	0.60
VEGF	activates	gene	0.60
CANCER	activates	gene	0.60
GSK3	activates	gene	0.60
IL-1	inhibits	gene	0.60
FLAVONOIDS	inhibits	gene	0.60
MAP2	biomarker_for	gene	0.60
FOXO	activates	gene	0.60
PKM2	activates	gene	0.60
GLUT3	contributes_to	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GLUT1-Mediated Glucose Flux Coefficient as Neuroprotection I	0.685	translational neuroscience	Which metabolic biomarkers can distingui

Mentioning Analyses (4)

Scientific analyses that reference this entity

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

neurodegeneration | 2026-04-10 | 0 hypotheses

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

neurodegeneration | 2026-04-10 | 0 hypotheses

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

neurodegeneration | 2026-04-10 | 0 hypotheses

Which metabolic biomarkers can distinguish therapeutic response from disease pro

translational neuroscience | 2026-04-04 | 7 hypotheses Top: 0.819

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (5)

Multi-agent debates referencing this entity

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

closed · Rounds: 0 · Score: 0.66 · 2026-04-21

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

closed · Rounds: 0 · Score: 0.64 · 2026-04-21

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Which metabolic biomarkers can distinguish therapeutic response from disease pro

closed · Rounds: 4 · Score: 0.92 · 2026-04-04

GLUT1

Understanding Entity Pages

Summary

Wiki Pages (6)

VGLUT1 Protein (SLC17A7)

VGLUT1 Gene

GLUT1 Protein (Glucose Transporter 1)

SLC17A1 — Solute Carrier Family 17 Member 1 (VGLUT1)

GLUT1 Protein

VGLUT1 Protein

Pathway Diagram

Outgoing (237)

Incoming (80)

Targeting Hypotheses (1)

Mentioning Analyses (4)

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Which metabolic biomarkers can distinguish therapeutic response from disease pro

Experiments (0)

Related Papers (0)

Debates (5)

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Which metabolic biomarkers can distinguish therapeutic response from disease pro