concept

ESCC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ESCC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

0Analyses

0Outgoing

17Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ESCC
Key Genes/Proteins	AKT, CDKN2A, EFNB1, EPHB4, ERK, GABRD
Related Diseases	HEAT_STIMULATION
Related Pathways	cell cycle pathway, Notch pathway

Pathway Diagram

graph TD
    ESCC["ESCC"]
    TP53["TP53"] -->|"causes"| ESCC
    RB1["RB1"] -->|"causes"| ESCC
    CDKN2A["CDKN2A"] -->|"causes"| ESCC
    PIK3CA["PIK3CA"] -->|"causes"| ESCC
    NOTCH1["NOTCH1"] -->|"causes"| ESCC
    Wnt_pathway["Wnt pathway"] -->|"participates in"| ESCC
    cell_cycle_pathway["cell cycle pathway"] -->|"participates in"| ESCC
    Notch_pathway["Notch pathway"] -->|"participates in"| ESCC

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (17)

Source	Relation	Type	Str
PIK3CA	causes	gene	0.90
NOTCH1	causes	gene	0.90
TP53	causes	gene	0.90
RB1	causes	gene	0.90
CDKN2A	causes	gene	0.90
GABRD	associated_with	gene	0.80
Wnt pathway	participates_in	pathway	0.70
cell cycle pathway	participates_in	pathway	0.70
Notch pathway	participates_in	pathway	0.70
HEAT_STIMULATION	activates	phenotype	0.64
KCNK2	inhibits	gene	0.56
EFNB1	implicated_in	gene	0.50
TP53	implicated_in	gene	0.50
ERK	implicated_in	gene	0.50
AKT	implicated_in	gene	0.50
SRC	implicated_in	gene	0.50
EPHB4	implicated_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ESCC in their description or question text

No additional research found