gene

FGFR3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGFR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

98Connections

0Hypotheses

0Analyses

50Outgoing

26Incoming

0Experiments

0Debates

Summary

Page for FGFR3 - Fibroblast Growth Factor Receptor 3

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🧬 Gene Info

Gene Symbol	FGFR3
Aliases	Page for FGFR3
Chromosome	4p16.3
Protein Family	FGFR tyrosine kinase family
Protein Type	Receptor
Function	FGFR3 (Fibroblast Growth Factor Receptor 3) is a receptor tyrosine kinase that binds FGFs.
Primary Expression	chondrocytes where it negatively regulates bone growth, explaining why activating FGFR3 mutations cause achondroplasia, the most common form of dwarfi
Molecular Weight	88.5 kDa
Amino Acids	808 aa
Exons	19
Pathways	MAPK, PI3K
UniProt ID	P22607
GeneCards	FGFR3
Human Protein Atlas	FGFR3
Extracellular Domain	Contains three immunoglobulin-like domains (D1-D3) that mediate FGF binding
Associated Diseases	Als, bladder cancer, Breast Cancer, cancer, Carcinoma
Interactions	AND, BMPR1A, CANCER, EP300, KDM6A, KMT2D
KG Connections	98 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: FGFR3 — AlphaFold P22607 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FGFR3 - Fibroblast Growth Factor Receptor 3

gene · 1352 words

→

FGFR3 Protein

protein · 574 words

→

Pathway Diagram

graph TD
    FGFR3["FGFR3"]
    bladder_cancer{"bladder cancer"}
    FGFR3 -->|"causes"| bladder_cancer
    TP53["TP53"]
    FGFR3 -->|"interacts with"| TP53
    RB1["RB1"]
    FGFR3 -->|"interacts with"| RB1
    Cancer{"Cancer"}
    FGFR3 -->|"therapeutic target"| Cancer
    Als{"Als"}
    FGFR3 -->|"associated with"| Als
    Tumor{"Tumor"}
    FGFR3 -->|"associated with"| Tumor
    FGFR3 -->|"therapeutic target"| Tumor
    Ms{"Ms"}
    FGFR3 -->|"therapeutic target"| Ms
    Glioblastoma{"Glioblastoma"}
    FGFR3 -->|"therapeutic target"| Glioblastoma
    FGFR3 -->|"associated with"| Cancer
    Aging{"Aging"}
    FGFR3 -->|"activates"| Aging
    FGFR3 -->|"activates"| Ms
    BMPR1A["BMPR1A"]
    BMPR1A -->|"interacts with"| FGFR3
    RB1 -->|"associated with"| FGFR3
    OVERVIEW["OVERVIEW"]
    OVERVIEW -->|"therapeutic target"| FGFR3
    TP53 -->|"associated with"| FGFR3
    CDK4["CDK4"]
    CDK4 -->|"associated with"| FGFR3
    TEAD1["TEAD1"]
    TEAD1 -->|"therapeutic target"| FGFR3
    EGFR["EGFR"]
    EGFR -->|"associated with"| FGFR3
    KDM4A["KDM4A"]
    KDM4A -->|"associated with"| FGFR3
    EP300["EP300"]
    EP300 -->|"activates"| FGFR3
    GENES["GENES"]
    GENES -->|"therapeutic target"| FGFR3
    IDH1["IDH1"]
    IDH1 -->|"associated with"| FGFR3
    NF1["NF1"]
    NF1 -->|"associated with"| FGFR3
    style FGFR3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (72)

Target	Relation	Type	Str
bladder cancer	causes	disease	0.90
Cancer	therapeutic_target	disease	0.85
Tumor	associated_with	disease	0.75
Als	associated_with	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
CANCER	therapeutic_target	gene	0.70
OVERVIEW	therapeutic_target	gene	0.70
CANCER	associated_with	gene	0.70
KRAS	associated_with	gene	0.70
TP53	associated_with	gene	0.70
TP53	interacts_with	gene	0.70
RB1	interacts_with	gene	0.70
GENES	therapeutic_target	gene	0.70
Glioblastoma	therapeutic_target	disease	0.65
Myeloma	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Coronary Artery Disease	therapeutic_target	disease	0.65
Longevity	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Leukemia	activates	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	biomarker_for	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Carcinoma	associated_with	disease	0.65
Breast Cancer	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Pancreatic Cancer	associated_with	disease	0.65
TFAP4	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60
NF1	associated_with	gene	0.60
RAS	expressed_in	gene	0.60
DNA	biomarker_for	gene	0.60
Immune Checkpoint	associated_with	pathway	0.60
Checkpoint Inhibitor	associated_with	pathway	0.60
Immunotherapy	associated_with	pathway	0.60
INFLAMMATION	associated_with	gene	0.60
IDH1	associated_with	gene	0.60
BICD2	associated_with	gene	0.60
MITF	associated_with	gene	0.60
HSPA1A	associated_with	gene	0.60
BRCA2	associated_with	gene	0.60

Incoming (26)

Source	Relation	Type	Str
BMPR1A	interacts_with	gene	0.70
GENES	therapeutic_target	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
RB1	associated_with	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
TP53	associated_with	gene	0.60
KDM4A	associated_with	gene	0.60
EP300	activates	gene	0.60
KMT2D	therapeutic_target	gene	0.60
PIK3CA	associated_with	gene	0.60
KDM6A	therapeutic_target	gene	0.60
CDK4	associated_with	gene	0.60
TEAD1	therapeutic_target	gene	0.60
EGFR	associated_with	gene	0.60
FGFR1	translocates_to	gene	0.60
AND	activates	gene	0.60
GENES	associated_with	gene	0.60
CANCER	activates	gene	0.60
IDH1	associated_with	gene	0.60
NF1	associated_with	gene	0.60
OVERVIEW	activates	gene	0.60
KMT2D	activates	gene	0.60
KDM6A	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGFR3 in their description or question text

No additional research found