concept

ACHE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACHE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1070Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

ACHE is a concept in neurodegeneration research. Key relationships include: activates, inhibits, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 279 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ACHE
Key Genes/Proteins	AB, ABCA1, ACETYL-COA, AD, ADAM10, AGING
Related Diseases	acetylcholine, Aging, Als, ALS
Related Pathways	Akt

Pathway Diagram

graph TD
    ACHE["ACHE"]
    ACHE -->|"activates"| Alzheimer["Alzheimer"]
    ACHE -->|"activates"| Neurodegeneration["Neurodegeneration"]
    ACHE -->|"activates"| Als["Als"]
    ACHE -->|"activates"| Inflammation["Inflammation"]
    ACHE -->|"activates"| Ms["Ms"]
    ACHE -->|"activates"| Anxiety["Anxiety"]
    ACHE -->|"target for"| Cardiac["Cardiac"]
    BPMC["BPMC"] -->|"inhibits"| ACHE
    MBP["MBP"] -->|"activates"| ACHE
    GENES["GENES"] -->|"activates"| ACHE
    MANF["MANF"] -->|"activates"| ACHE
    FLAVONOIDS["FLAVONOIDS"] -.biomarker for.-> ACHE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| ACHE
    PI3K["PI3K"] -->|"activates"| ACHE
    AKT["AKT"] -->|"activates"| ACHE
    TNF["TNF"] -.biomarker for.-> ACHE
    CAT["CAT"] -.biomarker for.-> ACHE

Outgoing (892)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ACHE	data_in	dataset_row	0.00
ds-6784494f1741	data_in	dataset	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	inhibits	disease	0.85
denervation	promotes	phenotype	0.85
Acetylcholine	degrades	compound	0.82
Apoptosis	activates	pathway	0.80
Neurodegeneration	activates	disease	0.75
Als	activates	disease	0.75
TAU	protects_against	gene	0.70
TREM2	interacts_with	gene	0.70
FTD	targets	disease	0.70
BACE1	targets	gene	0.70
NEURONS	mediates	cell_type	0.70
NEURONS	regulates	cell_type	0.70
HTT	expresses	gene	0.70
PSEN1	targets	gene	0.70
MAO	targets	gene	0.70
NEURONS	interacts_with	cell_type	0.70
MICROGLIA	interacts_with	cell_type	0.70
JAK	inhibits	gene	0.70
MICROGLIA	mediates	cell_type	0.70
JAK	markers	gene	0.70
WNT	activates	gene	0.70
APOE	interacts_with	gene	0.70
FTD	associated_with	disease	0.70
STAT3	targets	gene	0.70
WNT	protects_against	gene	0.70
WNT	regulates	gene	0.70
MACROPHAGE	transports	cell_type	0.70
NOTCH	activates	gene	0.70
MICROGLIA	targets	cell_type	0.70
BACE1	inhibits	gene	0.70
OPTN	activates	gene	0.70
APOE	activates	gene	0.70
GRIA1	regulates	gene	0.70
FUS	associated_with	gene	0.70
PYCARD	activates	gene	0.70
LRRK2	activates	gene	0.70
TNF	activates	gene	0.70
P2RX7	activates	gene	0.70
DRD2	targets	gene	0.70
CDK5	inhibits	gene	0.70
BACE1	interacts_with	gene	0.70
APOE	targets	gene	0.70
STING	disrupts	gene	0.70
ASTROCYTE	markers	cell_type	0.70
XIAP	activates	gene	0.70
CGAS	activates	gene	0.70
FOXP3	activates	gene	0.70

Incoming (178)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ACHE	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-6784494f1741	data_in	dataset	1.00
Bpmc	inhibits	compound	0.90
Bpmc	downregulates	compound	0.90
Fisetin	downregulates	compound	0.85
Chlorogenic acid	downregulates	compound	0.85
NORAD	regulates	gene	0.80
APOPTOSIS	activates	gene	0.80
BPMC	inhibits	drug	0.72
OXIDATIVE STRESS	activates	gene	0.70
NEUROTOXICITY	activates	gene	0.70
GFAP	activates	gene	0.70
APP	causes	gene	0.65
CAT	biomarker_for	gene	0.60
ANXIETY	associated_with	gene	0.60
NRF2	activates	gene	0.60
CATALASE	inhibits	gene	0.60
BIN1	associated_with	gene	0.60
SMOC2	contributes_to	gene	0.60
VEGFB	associated_with	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
PI3K	activates	gene	0.60
AKT	activates	gene	0.60
TNF	biomarker_for	gene	0.60
AB	co_discussed	gene	0.60
ABCA1	regulates	gene	0.60
AB	inhibits	gene	0.60
FLAVONOIDS	biomarker_for	gene	0.60
TAU	activates	gene	0.60
AMPK	activates	gene	0.60
PRESENILIN	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ROS	activates	gene	0.60
AXON	activates	gene	0.60
TUBULIN	activates	gene	0.60
NEURON	activates	gene	0.60
NEUROTOXICITY	causes	gene	0.60
TAU	causes	gene	0.60
BDNF	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
AMYLOID	causes	gene	0.60
IL-6	inhibits	gene	0.60
MBP	inhibits	gene	0.60
VEGFA	associated_with	gene	0.60
MC4R	associated_with	gene	0.60
GENES	associated_with	gene	0.60
APP/PS1	transports	gene	0.60
CHAT	transports	gene	0.60
MAF	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACHE in their description or question text

No additional research found