concept

ACAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ACAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

355Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

5Experiments

0Debates

Summary

ACAT1 is a concept in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Alzheimer, Cancer. Connected to 165 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ACAT1
Key Genes/Proteins	ABCA1, ACETYL-COA, Actin, ADAM10, AKT, ALDH2
Related Diseases	Als, Alzheimer, Alzheimer's disease
Related Pathways	Akt

Pathway Diagram

graph TD
    ACAT1["ACAT1"]
    ACAT1 -->|"activates"| Cancer["Cancer"]
    ACAT1 -->|"activates"| Tumor["Tumor"]
    ACAT1 -->|"activates"| liver_invasion["liver_invasion"]
    ACAT1 -->|"activates"| PI3K["PI3K"]
    ACAT1 -->|"activates"| ERBB2["ERBB2"]
    ACAT1 -->|"activates"| AKT["AKT"]
    ACAT1 -->|"activates"| ERBB3["ERBB3"]
    ACAT1 -->|"activates"| TP53["TP53"]
    ERK["ERK"] -->|"activates"| ACAT1
    GAIN["GAIN"] -->|"activates"| ACAT1
    LYSOSOME["LYSOSOME"] -->|"regulates"| ACAT1
    ELF3["ELF3"] -->|"activates"| ACAT1
    PI3K -->|"activates"| ACAT1
    TP53 -->|"activates"| ACAT1
    ERBB3 -->|"activates"| ACAT1
    AKT -->|"activates"| ACAT1
    PHGDH["PHGDH"] -->|"causes"| ACAT1
    CANCER["CANCER"] -->|"activates"| ACAT1

Outgoing (228)

Target	Relation	Type	Str
Liver Invasion	contributes_to	phenotype	0.85
SOAT1	inhibits	gene	0.70
Ischemia	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Depression	associated_with	disease	0.65
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Cancer	inhibits	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Parkinson	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
liver_invasion	activates	phenotype	0.64
RB1CC1	associated_with	gene	0.60
P53	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
STX17	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
TP53	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
Mtor	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
PI3K	activates	gene	0.60
ERBB2	activates	gene	0.60
AKT	activates	gene	0.60
ERBB3	activates	gene	0.60
TP53	activates	gene	0.60
MEIS1	activates	gene	0.60
ELF3	activates	gene	0.60
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
Mapk	activates	pathway	0.60
AKT	therapeutic_target	gene	0.60
ELF3	therapeutic_target	gene	0.60
ERBB2	therapeutic_target	gene	0.60
ERBB3	therapeutic_target	gene	0.60

Incoming (127)

Source	Relation	Type	Str
LRP1	interacts_with	gene	0.70
PIK3C3	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
EP300	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
P62	associated_with	gene	0.60
LC3	associated_with	gene	0.60
TP53	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
RB1	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
ATG	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
ACETYL-COA	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
STX17	associated_with	gene	0.60
CREB	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
P53	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
STROKE	inhibits	gene	0.60
WIPI2	associated_with	gene	0.60
ALDH2	regulates	gene	0.60
TARDBP	regulates	gene	0.60
ROS	inhibits	gene	0.60
LDHA	regulates	gene	0.60
MAPK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Folic acid-induced nephropathy model for hyperoside renoprotection	validation	chronic kidney disease	0.900	folic acid-induced nephropathy	proposed	N/A
Unilateral ureteral obstruction model for hyperoside treatment	validation	chronic kidney disease	0.900	unilateral ureteral obstructio	proposed	N/A
Hyperoside-ACAT1 direct binding interaction studies	exploratory	chronic kidney disease	0.850	in vitro protein-ligand bindin	proposed	N/A
Acat1 knockdown functional validation experiment	exploratory	chronic kidney disease	0.800	Acat1 knockdown cells/tissues	proposed	N/A
L-carnitine rescue experiments in metabolic pathway	exploratory	chronic kidney disease	0.800	ACAT1 knockdown with L-carniti	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ACAT1 in their description or question text

No additional research found