concept

HIPPOCAMPUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIPPOCAMPUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1973Connections

5Hypotheses

3Analyses

50Outgoing

50Incoming

1Experiments

3Debates

Summary

HIPPOCAMPUS is a concept in neurodegeneration research. Key relationships include: co discussed, associated with, causes. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 84 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HIPPOCAMPUS
Key Genes/Proteins	ABCA7, ABI3, ACHE, ACSL4, ADAM10, AIF1
Related Diseases	ACETYLCHOLINE, AGING, ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Theta Pacemaker Neurons (Hippocampus)

cell · 1507 words

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Pathway Diagram

graph TD
    HIPPOCAMPUS["HIPPOCAMPUS"]
    HIPPOCAMPUS -->|"activates"| Memory["Memory"]
    HIPPOCAMPUS -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    BDNF["BDNF"] -->|"expressed in"| HIPPOCAMPUS
    BMSC_exos["BMSC-exos"] -->|"expressed in"| HIPPOCAMPUS
    SNCA["SNCA"] -->|"expressed in"| HIPPOCAMPUS
    mitophagy["mitophagy"] -->|"expressed in"| HIPPOCAMPUS
    blood_brain_barrier["blood-brain barrier"] -->|"regulates"| HIPPOCAMPUS
    neurogenesis["neurogenesis"] -->|"expressed in"| HIPPOCAMPUS
    SMAD7["SMAD7"] -->|"expressed in"| HIPPOCAMPUS
    autophagy["autophagy"] -->|"expressed in"| HIPPOCAMPUS
    GFAP["GFAP"] -->|"expressed in"| HIPPOCAMPUS
    senescent_microglia["senescent microglia"] -->|"expressed in"| HIPPOCAMPUS

Outgoing (625)

Target	Relation	Type	Str
MICROGLIA	regulates	cell_type	0.95
NEURON	activates	cell_type	0.95
NEUROGENESIS	regulates	process	0.95
memory	involved_in	phenotype	0.95
NEUROGENESIS	associated_with	process	0.95
NEURON	regulates	cell_type	0.95
NEURON	protects_against	cell_type	0.95
stress response	involved_in	process	0.90
AD vulnerability	associated_with	phenotype	0.90
Post-Stroke Depression	correlates_with	disease	0.85
cognitive performance	mediates	phenotype	0.85
NEUROINFLAMMATION	inhibits	process	0.80
NEURON	therapeutic_target	cell_type	0.80
NEURODEGENERATION	causes	process	0.80
cognitive decline	involved_in	phenotype	0.80
NEURON	interacts_with	cell_type	0.80
TAU	activates	protein	0.80
MICROGLIA	inhibits	cell_type	0.80
Alzheimer disease	vulnerability_locus_for	disease	0.75
Memory	activates	phenotype	0.70
AMYLOID	protects_against	protein	0.70
NEUROGENESIS	treats	phenotype	0.70
Alzheimer's disease	biomarker_for	disease	0.70
AKT	stabilizes	gene	0.70
PARKINSON	stabilizes	disease	0.70
PARKINSON	treats	disease	0.70
TEMPORAL LOBE	causes	brain_region	0.65
IL-6	activates	gene	0.65
IL-6	contributes_to	gene	0.65
LOCUS COERULEUS	exacerbates	brain_region	0.65
STING	activates	gene	0.65
COGNITIVE DECLINE	interacts_with	phenotype	0.65
STAT3	activates	gene	0.65
NRF2	inhibits	gene	0.65
MTOR	activates	gene	0.65
IL6	activates	gene	0.65
SQSTM1	expressed_in	gene	0.65
AMYLOID	treats	protein	0.65
SPINAL CORD	protects_against	brain_region	0.65
MICROGLIA	expressed_in	cell_type	0.65
SPINAL CORD INJURY	protects_against	disease	0.65
ER STRESS	regulates	phenotype	0.65
NEURON	biomarker_for	cell_type	0.65
PREFRONTAL	associated_with	brain_region	0.65
PYRAMIDAL NEURONS	activates	cell_type	0.65
MICROGLIA	activates	cell_type	0.65
GLUTAMATE	causes	phenotype	0.65
TAU	targets	gene	0.65
GFAP	regulates	gene	0.65
ENDOTHELIAL CELLS	treats	cell_type	0.65

Incoming (1348)

Source	Relation	Type	Str
NF-KB	associated_with	protein	1.00
AMYLOID	associated_with	protein	1.00
MICROGLIA	activates	cell_type	1.00
APP	associated_with	gene	1.00
MICROGLIA	associated_with	cell_type	1.00
TAU	associated_with	protein	1.00
ASTROCYTES	associated_with	cell_type	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
BDNF	associated_with	gene	1.00
SLC17A7	enriched_in	gene	0.95
CORTEX	activates	brain_region	0.95
CORTEX	inhibits	brain_region	0.95
CORTEX	regulates	brain_region	0.95
ALZHEIMER'S DISEASE	interacts_with	disease	0.95
DEPRESSION	activates	disease	0.95
APP	expressed_in	gene	0.95
32034157	found in	paper	0.90
TNF	expressed_in	gene	0.90
RNA	expressed_in	gene	0.90
26175670	were higher along the septo-temporal axis in the septal direction	paper	0.90
epilepsy	affects	disease	0.90
BDNF-TrkB signaling	active_in	pathway	0.90
NMDA receptor	expressed_in	receptor	0.90
aging	affects	disease	0.90
BDNF	inhibits	gene	0.90
Alzheimer's disease	affects	disease	0.90
synaptic plasticity	active_in	pathway	0.90
IL-6	associated_with	gene	0.90
PVB	expressed_in	gene	0.90
HCN2	expressed_in	gene	0.90
SPP1	expressed_in	entity	0.90
microglia	expressed_in	cell_type	0.90
1-bromopropane	causes	compound	0.90
HCN1	expressed_in	entity	0.90
glutamate signaling	active_in	pathway	0.90
BDNF	expressed_in	gene	0.90
neurodegeneration	affects	disease	0.90
neuroinflammation	affects	disease	0.90
APP	expressed_in	gene	0.90
unfolded protein response	active_in	pathway	0.90
depression	affects	disease	0.90
Neurodegeneration-Related Gene Expression	expressed_in	process	0.90
TREM2	expressed_in	gene	0.88
BCL2	expressed_in	protein	0.88
Gabaergic Interneurons	expressed_in	cell_type	0.85
Neuronal Cholesterol Accumulation	expressed_in	phenotype	0.85
C4B	upregulated_in	gene	0.85
MCH	expressed_in	protein	0.85
Cadmium	causes	compound	0.85
Cortisol	modulates	compound	0.85

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
VEGF-family genetic control of vascular-neuronal coupling in	0.626	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Cell-state stratification is required to resolve VEGF Family	0.612	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	VEGF Family GWAS Signals and Cerebrovasc
Hippocampus ages transcriptionally faster than cerebellum, d	0.516	Alzheimer's disease	Allen Mouse Brain Aging Atlas: cross-age
Composite Aging Risk Score (CARS) identifies hippocampus as	0.380	Alzheimer's disease	Gene expression changes in aging mouse b

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Resting-state functional connectivity analysis in ADAD carriers showed	neuropathology	Alzheimer's disease	0.500	0.00	in_vivo	extracted	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning HIPPOCAMPUS in their description or question text

No additional research found