gene

OXIDATIVE STRESS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXIDATIVE STRESS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9658Connections

3Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

OXIDATIVE STRESS is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 3134 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	OXIDATIVE STRESS
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/Compounds	AFMK, CARBIDOPA, CURCUMIN, DAPAGLIFLOZIN, DIMETHYL FUMARATE, DONEPEZIL
Interactions	6-OHDA, ABCD1, ABCD2, ABCD3, ABCG2, ACC
KG Connections	5117 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated with"| ALS["ALS"]
        SOD1["SOD1"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        P62["P62"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        AKT["AKT"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    end
    subgraph Therapeutic["Therapeutic"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Als["Als"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Diabetes["Diabetes"]
    end
    subgraph Signaling["Signaling"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Inflammation["Inflammation"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Autophagy["Autophagy"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Lipid_Metabolism["Lipid Metabolism"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Epigenetic["Epigenetic"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Oxidative_Stress["Oxidative Stress"]
        AUTOPHAGY_1["AUTOPHAGY"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        APOPTOSIS["APOPTOSIS"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    end
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Lipid_Metabolism fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Epigenetic fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SOD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style P62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AKT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (3742)

Target	Relation	Type	Str
Depression	activates	disease	1.00
Lipid Metabolism	activates	pathway	1.00
Ferroptosis	activates	pathway	1.00
Ferroptosis	inhibits	pathway	1.00
Inflammation	expressed_in	disease	1.00
Cancer	therapeutic_target	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Diabetes	associated_with	disease	1.00
Als	expressed_in	disease	1.00
Mitophagy	activates	pathway	1.00
Tumor	therapeutic_target	disease	1.00
CANCER	associated_with	gene	1.00
Cancer	activates	disease	1.00
Mitophagy	regulates	pathway	1.00
Infection	associated_with	disease	1.00
Tumor	activates	disease	1.00
AGING	associated_with	gene	1.00
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	1.00
HO-1	activates	gene	1.00
AUTOPHAGY	regulates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
Mitochondrial Function	associated_with	pathway	1.00
Oxidative Stress	associated_with	pathway	1.00
MITOCHONDRIA	associated_with	gene	1.00
ALS	associated_with	gene	1.00
Aging	associated_with	disease	1.00
AUTOPHAGY	activates	gene	1.00
Neuroinflammation	associated_with	disease	1.00
Cardiovascular	associated_with	disease	1.00
CANCER	activates	gene	1.00
ALZHEIMER'S DISEASE	targets	gene	1.00
ALZHEIMER	associated_with	gene	1.00
Tumor	associated_with	disease	1.00
UBIQUITIN	activates	gene	1.00
NRF2	associated_with	gene	1.00
Ferroptosis	associated_with	pathway	1.00
FERROPTOSIS	associated_with	gene	1.00
PARKINSON	associated_with	gene	1.00
Als	associated_with	disease	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
Alzheimer	associated_with	disease	1.00
Autophagy	associated_with	pathway	1.00
Neurodegeneration	associated_with	disease	1.00
INFLAMMATION	associated_with	gene	1.00
Obesity	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Parkinson	associated_with	disease	1.00
AUTOPHAGY	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
Autophagy	inhibits	pathway	1.00

Incoming (5916)

Source	Relation	Type	Str
AKT	associated_with	gene	1.00
CANCER	causes	gene	1.00
INFLAMMATION	activates	gene	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
Cancer	causes	disease	1.00
NEURODEGENERATION	regulates	gene	1.00
INFLAMMATION	expressed_in	gene	1.00
STROKE	regulates	gene	1.00
MICROGLIA	activates	gene	1.00
ROS	inhibits	gene	1.00
ROS	regulates	gene	1.00
ROS	regulates	gene	1.00
ROS	inhibits	gene	1.00
PARKINSON	therapeutic_target	gene	1.00
AUTOPHAGY	activates	gene	1.00
KEAP1	activates	gene	1.00
AUTOPHAGY	activates	gene	1.00
Aging	inhibits	disease	1.00
MTDNA	activates	gene	1.00
Cardiovascular	activates	disease	1.00
AKT	therapeutic_target	gene	1.00
GENES	regulates	gene	1.00
Als	expressed_in	disease	1.00
ERK	activates	gene	1.00
Fibrosis	activates	disease	1.00
LC3	activates	gene	1.00
PI3K	therapeutic_target	gene	1.00
OVERVIEW	therapeutic_target	gene	1.00
Tumor	activates	disease	1.00
Neurodegeneration	associated_with	disease	1.00
Tumor	inhibits	disease	1.00
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	1.00
Cardiovascular	therapeutic_target	disease	1.00
GENES	associated_with	gene	1.00
P62	activates	gene	1.00
DNA	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	1.00
Cancer	activates	disease	1.00
AMPK	activates	gene	1.00
Alzheimer	regulates	disease	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
Parkinson	activates	disease	1.00
NEURODEGENERATION	associated_with	gene	1.00
INFLAMMATION	associated_with	gene	1.00
Inflammation	associated_with	disease	1.00
Parkinson	associated_with	disease	1.00
NEURODEGENERATION	associated_with	gene	1.00
PARKINSON	associated_with	gene	1.00

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
FOXO3-Pioneer Factor Complex Stabilizes Heterochromatin Unde	0.700	neurodegeneration	Investigate mechanisms of epigenetic rep
Amyloid-beta induces secondary pericyte senescence after con	0.640	neurodegeneration	Does pericyte senescence drive BBB break
NRF2 Activation to Counteract Oxidative Stress from RGS6 Def	0.518	neurodegeneration	Does RGS6 upregulation or D2 autorecepto