concept

NOTCH SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOTCH SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

150Connections

0Hypotheses

0Analyses

37Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NOTCH SIGNALING
Key Genes/Proteins	AKT, AMYLOID, ANGPT1, APP, AQP1, BIN1
Related Diseases	AGING, ALZHEIMER'S DISEASE, APOPTOSIS, CANCER, CHEMORESISTANCE

Pathway Diagram

graph TD
    NOTCH_SIGNALING["NOTCH SIGNALING"]
    NOTCH_SIGNALING -->|"inhibits"| Neurogenesis["Neurogenesis"]
    NOTCH_SIGNALING -->|"regulates"| Developing_Brain_Cell_Fate["Developing Brain Cell Fate"]
    NOTCH_SIGNALING -->|"mediates"| Lateral_Inhibition["Lateral Inhibition"]
    GFAP["GFAP"] -->|"regulates"| NOTCH_SIGNALING
    VIM["VIM"] -->|"regulates"| NOTCH_SIGNALING
    CK2["CK2"] -->|"regulates"| NOTCH_SIGNALING
    PP2A["PP2A"] -->|"regulates"| NOTCH_SIGNALING
    DLK2["DLK2"] -->|"involved_in"| NOTCH_SIGNALING
    SOX2["SOX2"] -->|"involved_in"| NOTCH_SIGNALING
    LRP1_Inhibition["LRP1 Inhibition"] -->|"inhibits"| NOTCH_SIGNALING
    VIMENTIN["VIMENTIN"] -->|"regulates"| NOTCH_SIGNALING

Outgoing (37)

Target	Relation	Type	Str
Developing Brain Cell Fate	regulates	process	0.90
Neurogenesis	inhibits	process	0.90
Lateral Inhibition	mediates	process	0.85
endothelial cells	active_in	cell_type	0.70
astrocytes	active_in	cell_type	0.70
neural stem cells	active_in	cell_type	0.70
blood-brain barrier	active_in	brain_region	0.70
CANCER	causes	disease	0.65
APOPTOSIS	activates	phenotype	0.65
APOPTOSIS	regulates	phenotype	0.65
OLIGODENDROCYTE	regulates	cell_type	0.65
macrophages	active_in	cell_type	0.60
unfolded protein response	crosstalk_with	pathway	0.60
CANCER	stabilizes	disease	0.60
CHEMORESISTANCE	implicated_in	phenotype	0.55
AMYLOID	associated_with	protein	0.50
UBIQUITIN	associated_with	protein	0.45
TBK1	associated_with	gene	0.45
PSEN1	associated_with	gene	0.45
APP	associated_with	gene	0.45
BIN1	associated_with	gene	0.45
NEURONS	associated_with	cell_type	0.45
AKT	associated_with	gene	0.45
VEGF	associated_with	gene	0.45
AGING	associated_with	phenotype	0.45
APOPTOSIS	associated_with	phenotype	0.45
PSEN2	associated_with	gene	0.45
OLIGODENDROCYTE	associated_with	cell_type	0.45
LEUKEMIA	associated_with	disease	0.45
LRP1	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
ASTROCYTE	associated_with	cell_type	0.45
GFAP	associated_with	gene	0.45
CANCER	associated_with	disease	0.45
TUMOR CELLS	associated_with	cell_type	0.45
NEUROGENESIS	associated_with	phenotype	0.45
NOTCH1	associated_with	gene	0.45

Incoming (113)

Source	Relation	Type	Str
VIM	regulates	protein	0.90
GFAP	regulates	protein	0.90
DLK2	involved_in	gene	0.85
SOX2	involved_in	gene	0.85
LRP1 Inhibition	inhibits	mechanism	0.85
VIMENTIN	regulates	protein	0.85
NOTCH	participates_in	gene	0.80
APP	participates_in	gene	0.80
NOTCH1	participates_in	gene	0.80
SNCA	regulates	gene	0.75
DLL4	participates_in	gene	0.70
JAG1	participates_in	gene	0.70
LRP1	participates_in	gene	0.70
SIRT1	participates_in	gene	0.70
AKT	participates_in	gene	0.70
PI3K	participates_in	gene	0.70
RB1	participates_in	gene	0.70
VEGF	participates_in	gene	0.70
HIF	participates_in	gene	0.70
LRP1	causes	gene	0.65
APP	degrades	gene	0.65
BIN1	regulates	gene	0.65
NEURONS	targets	cell_type	0.65
LRP1	inhibits	gene	0.65
APOE	participates_in	gene	0.60
EGFR	participates_in	gene	0.60
CD36	participates_in	gene	0.60
HDAC8	participates_in	gene	0.60
stroke	involves	disease	0.60
EGF	participates_in	gene	0.60
TNF	participates_in	gene	0.60
neurodegeneration	involves	disease	0.60
DLL1	participates_in	gene	0.60
TRPM2	participates_in	gene	0.60
LDH	participates_in	gene	0.60
ACE	participates_in	gene	0.60
MCT1	participates_in	gene	0.60
CK2	participates_in	gene	0.60
BIN1	participates_in	gene	0.60
HES1	participates_in	gene	0.60
VEGFA	participates_in	gene	0.60
RNF20	participates_in	gene	0.60
TP53	participates_in	gene	0.60
MTOR	participates_in	gene	0.60
glioblastoma	involves	disease	0.60
ANO9	participates_in	gene	0.60
frontotemporal dementia	involves	disease	0.60
FBXW7	participates_in	gene	0.60
FTLD	participates_in	gene	0.60
GBM	participates_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NOTCH SIGNALING in their description or question text

No additional research found