protein

DNMT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNMT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

443Connections

3Hypotheses

4Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

DNMT1 is a protein involved in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with ALS, Aging, Als. Connected to 156 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	DNMT1
Chromosome	19p13.2<br>
Protein Type	Epigenetic Regulator
Target Class	Epigenetic Regulator
Function	DNMT1 maintains DNA methylation patterns by copying methylation from the parental DNA strand to the newly synthesized strand.
Mechanism of Action	Small molecule inhibitor of DNA methyltransferase activity
Primary Expression	all tissues with high expression in: - Developing brain (neurons and progenitors) - Adult hippocampus (CA1, dentate gyrus) - Cere
Druggability	Medium (0.52)
Clinical Stage	Approved
Molecular Weight	183 kDa
Pathways	Differentiation, Epigenetic, Immune Response
UniProt ID	P26358
NCBI Gene ID	1785
Ensembl ID	ENSG00000123091
GeneCards	DNMT1
Human Protein Atlas	DNMT1
Associated Diseases	Als, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Ataxia
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	AKT, amyotrophic lateral sclerosis, AND, APOPTOSIS, AUTOPHAGY, BAX
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	DNMT1-Targeting Antisense Oligonucleotide Reset DNMT1 Compensation Window During Synaptic Resilien DNMT1 Downregulation to Correct Genome-Wide Hypome
KG Connections	443 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — DNMT1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

3PTA — X-ray / Cryo-EM

🔮 AI Predicted Structure

P26358 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DNMT1 Gene

gene · 733 words

→

DNMT1 Protein

protein · 666 words

→

Pathway Diagram

graph TD
    DNMT1["DNMT1"]
    DNMT1 -->|"inhibits"| BMAL1["BMAL1"]
    DNMT1 -->|"regulates"| Ms["Ms"]
    DNMT1 -->|"activates"| Carcinoma["Carcinoma"]
    DNMT1 -->|"expressed in"| Cancer["Cancer"]
    DNMT1 -->|"interacts"| Als["Als"]
    DNMT1 -->|"interacts"| Schizophrenia["Schizophrenia"]
    DNMT1 -->|"target for"| Aging["Aging"]
    DNMT1 -->|"regulates"| GENES["GENES"]
    h_782e55f6["h-782e55f6"] -->|"target for"| DNMT1
    h_74777459["h-74777459"] -->|"target for"| DNMT1
    RB1["RB1"] -->|"regulates"| DNMT1
    IL17A["IL17A"] -->|"activates"| DNMT1
    MAPK["MAPK"] -->|"activates"| DNMT1
    PDPK1["PDPK1"] -->|"regulates"| DNMT1
    CANCER["CANCER"] -->|"expressed in"| DNMT1
    RELN["RELN"] -->|"interacts"| DNMT1

Outgoing (318)

Target	Relation	Type	Str
BMAL1	inhibits	gene	0.90
CHKA	downregulates	gene	0.90
CHKB	downregulates	gene	0.90
epigenetic regulation	participates_in	pathway	0.85
Cancer Stem Cells	associated_with	cell_type	0.80
Triple-Negative Breast Cancer	associated_with	disease	0.80
Estrogen Receptor	associated_with	protein	0.80
CpG_methylation	methylates	epigenetic_mark	0.80
Carcinoma	activates	disease	0.75
Cancer	expressed_in	disease	0.75
Cancer	activates	disease	0.75
DNMT3A	stabilizes	gene	0.70
Autophagy	activates	pathway	0.70
BMAL1	regulates	gene	0.70
AKT	activates	gene	0.70
GENES	regulates	gene	0.70
Epithelial-Mesenchymal Transition	activates	pathway	0.70
neural stem cells	activates	cell_type	0.70
EZH2	regulates	gene	0.70
CANCER	activates	gene	0.70
UBIQUITIN	modifies	protein	0.70
SYNAPTIC PLASTICITY	protects_against	phenotype	0.70
ALZHEIMER'S DISEASE	causes	disease	0.70
NEURODEGENERATION	treats	phenotype	0.70
NEURODEGENERATION	inhibits	phenotype	0.70
NEURON	causes	cell_type	0.70
Atherosclerosis	activates	disease	0.65
Als	interacts_with	disease	0.65
Ferroptosis	activates	disease	0.65
Liver Cancer	expressed_in	disease	0.65
Carcinoma	causes	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Tumor	activates	disease	0.65
TET2	inhibits	gene	0.65
DNMT3A	associated_with	gene	0.65
Breast Cancer	therapeutic_target	disease	0.65
neurodegeneration	regulates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Spinal Muscular Atrophy	associated_with	disease	0.65
Inflammation	expressed_in	disease	0.65
Tumor	inhibits	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
DNMT3A	regulates	gene	0.65
Autism	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Spinocerebellar Ataxia	associated_with	disease	0.65

Incoming (125)

Source	Relation	Type	Str
h-74777459	targets	hypothesis	0.90
h-782e55f6	targets	hypothesis	0.90
Thermal adaptation	upregulates	process	0.85
Arsenic	upregulates	compound	0.85
NFKB	associated_with	gene	0.80
RB1	regulates	gene	0.80
NEURONS	treats	cell_type	0.70
MAPK	activates	pathway	0.70
IL17A	activates	protein	0.70
PDPK1	regulates	gene	0.70
LC3	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HTT	associated_with	gene	0.60
SETX	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
ALS4	associated_with	gene	0.60
SMN1	associated_with	gene	0.60
ATG7	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
ACTB	regulates	gene	0.60
ATG7	regulates	gene	0.60
BECN1	regulates	gene	0.60
CANCER	expressed_in	gene	0.60
DNA	associated_with	gene	0.60
MTORC1	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
NEURON	associated_with	gene	0.60
ALS	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
CD8	activates	gene	0.60
DNA	activates	gene	0.60
GENES	activates	gene	0.60
ACTB	activates	entity	0.60
ALS4	activates	entity	0.60
ATG7	activates	entity	0.60
BECN1	activates	entity	0.60
AND	activates	gene	0.60
P53	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ERK	activates	gene	0.60
rapamycin	targets	drug	0.60
ADRA2A	expressed_in	gene	0.60
DNMT3B	expressed_in	gene	0.60
DNA	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
DNMT1-Targeting Antisense Oligonucleotide Reset	0.648	neurodegeneration	Epigenetic clocks and biological aging i
DNMT1 Compensation Window During Synaptic Resilience Phase	0.528	neurodegeneration	What is the optimal therapeutic window d
DNMT1 Downregulation to Correct Genome-Wide Hypomethylation	0.380	neurodegeneration	Comparative epigenetic signatures across

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (14)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Assessment of Out-of-Pocket Costs for Robotic Cancer Surgery in US Adults. [PMID:31940036]	Nabi J, Friedlander DF, Chen X, Cole AP,	JAMA Netw Open	2020	1
Multidisciplinary Approach to Interstitial Lung Diseases: Nothing Is Better than [PMID:32709146]	Vancheri C, Basile A	Diagnostics (Basel)	2020	1
Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus. [PMID:29887377]	Quinodoz SA, Ollikainen N, Tabak B, Pall	Cell	2018	1
Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions. [PMID:28319113]	Shen JP, Zhao D, Sasik R, Luebeck J, Bir	Nat Methods	2017	1
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation [PMID:20644199]	McKenna A, Hanna M, Banks E, Sivachenko	Genome Res	2010	1
Prevalence of clinical and radiographic signs of osteoarthrosis of the temporoma [PMID:20395464]	Schmitter M, Essig M, Seneadza V, Balke	Dentomaxillofac Radiol	2010	1
Disrupting the epigenetic alliance: structural insights and therapeutic strategi [PMID:40960568]	Kamel EM, Ali MAM, Allam AA, Ahmed NA, A	Functional & integrative genom	2025	0
Flow cytometry of DNMT1 as a biomarker of hypomethylating therapies. [PMID:38345160]	Woost PG, William BM, Cooper BW, Ueda Os	Cytometry. Part B, Clinical cy	2024	0
DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppres [PMID:38755637]	Liu Y, Sun Y, Yang J, Wu D, Yu S, Liu J,	Molecular cancer	2024	0
Bi-functional CpG-STAT3 decoy oligonucleotide triggers multilineage differentiat [PMID:39171140]	Wang D, Kaniowski D, Jacek K, Su YL, Yu	Molecular therapy. Nucleic aci	2024	0
A precise and efficient circular RNA synthesis system based on a ribozyme derive [PMID:37378451]	Cui J, Zhang L, Zhang Z, Luo X, Liu Y, L	Nucleic acids research	2023	0
Channel branching and zigzagging in negative cloud-to-ground lightning. [PMID:28615706]	["Jiang R", "Qie X", "Zhang H", "Liu M",	Scientific reports	2017	0
Sequential transcriptional waves direct the differentiation of newborn neurons i [PMID:26940868]	["Telley L", "Govindan S", "Prados J", "	Science (New York, N.Y.)	2016	0
Incorporating theology into medical education. [PMID:23209119]	Adam Miller	CMAJ : Canadian Medical Associ	2013	0

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning DNMT1 in their description or question text

No additional research found

DNMT1

Understanding Entity Pages

Summary

Wiki Pages (2)

DNMT1 Gene

DNMT1 Protein

Pathway Diagram

Outgoing (318)

Incoming (125)

Targeting Hypotheses (3)

Mentioning Analyses (4)

Comparative epigenetic signatures across AD, PD, and ALS

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Epigenetic clocks and biological aging in neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (0)

Related Papers (14)

Debates (4)

What are the shared DNA methylation age acceleration and histone modification pa

Epigenetic clocks and biological aging in neurodegeneration

What gene expression changes in the aging mouse brain predict neurodegenerative

What are the mechanisms underlying what are the mechanisms by which gut microbio

Related Research