protein

P53

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P53: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2681Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

P53 is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 1671 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	P53
Pathways	Aging
GeneCards	P53
Human Protein Atlas	P53
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	APR-246, chemotherapy, Emodin, MDM2 antagonist Nutlin-3, rapamycin, RAPAMYCIN
Interactions	ACAT1, ACETYL-COA, ACOX1, ACSL4, Actin, ACVR2A
KG Connections	2652 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    P53["P53"] -->|"activates"| PUMA["PUMA"]
    P53["P53"] -->|"causes"| NEURODEGENERATION["NEURODEGENERATION"]
    P53["P53"] -->|"regulates"| APOPTOSIS["APOPTOSIS"]
    P53["P53"] -->|"regulates"| CELL_CYCLE["CELL_CYCLE"]
    P53["P53"] -->|"mediates"| ALS["ALS"]
    P53["P53"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    TP53["TP53"] -->|"encodes"| P53["P53"]
    POLY_PR["POLY_PR"] -->|"activates"| P53["P53"]
    SF3B1["SF3B1"] -->|"therapeutic target"| P53["P53"]
    TERT["TERT"] -->|"therapeutic target"| P53["P53"]
    style P53 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1613)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:P53	data_in	dataset_row	0.00
Als	treats	disease	1.00
MTOR	regulates	gene	1.00
Tumor	associated_with	disease	1.00
Als	associated_with	disease	1.00
Cancer	associated_with	disease	1.00
CANCER	inhibits	gene	1.00
Als	inhibits	disease	1.00
Tumor	therapeutic_target	disease	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Apoptosis	inhibits	pathway	1.00
Carcinoma	activates	disease	1.00
Senescence	regulates	disease	1.00
Inflammation	activates	disease	1.00
Aging	therapeutic_target	disease	1.00
Ferroptosis	regulates	pathway	1.00
Autophagy	activates	pathway	1.00
Cancer	activates	disease	1.00
FERROPTOSIS	regulates	gene	1.00
Senescence	inhibits	disease	1.00
Tumor	inhibits	disease	1.00
Nf-Κb	activates	pathway	1.00
Senescence	activates	disease	1.00
Tumor	regulates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Glycolysis	activates	pathway	1.00
Dna Repair	inhibits	pathway	1.00
AGING	activates	gene	1.00
Cancer	inhibits	disease	1.00
Cell Cycle	inhibits	pathway	1.00
Inflammation	implicated_in	disease	1.00
Als	interacts_with	disease	1.00
Mtor	regulates	pathway	1.00
Cell Cycle	activates	pathway	1.00
Als	regulates	disease	1.00
INFLAMMATION	regulates	gene	1.00
CANCER	implicated_in	gene	1.00
Inflammation	regulates	disease	1.00
Inflammation	inhibits	disease	1.00
AKT	activates	gene	1.00
DNA	regulates	gene	1.00
Ferroptosis	activates	pathway	1.00
Tumor	implicated_in	disease	1.00
Apoptosis	activates	pathway	1.00
Als	activates	disease	1.00
INFLAMMATION	activates	gene	1.00
MDM2	activates	gene	1.00
GENES	regulates	gene	1.00
Cancer	expressed_in	disease	1.00
DNA	inhibits	gene	1.00

Incoming (1068)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:P53	data_in	dataset_row	0.00
PI3K	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
NEURODEGENERATION	activates	gene	1.00
TP53	expressed_in	gene	1.00
GENES	inhibits	gene	1.00
CYTOKINES	activates	gene	1.00
DNA	inhibits	gene	1.00
CANCER	expressed_in	gene	1.00
PI3K	associated_with	gene	1.00
SIRT1	activates	gene	1.00
TP53	regulates	gene	1.00
CANCER	inhibits	gene	1.00
ROS	inhibits	gene	1.00
APOPTOSIS	inhibits	gene	1.00
ROS	activates	gene	1.00
NF-ΚB	activates	gene	1.00
APOPTOSIS	regulates	gene	1.00
TP53	inhibits	gene	1.00
APOPTOSIS	activates	gene	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
CANCER	activates	gene	1.00
TP53	therapeutic_target	gene	1.00
BAX	activates	gene	1.00
SLC7A11	activates	gene	1.00
OXIDATIVE STRESS	regulates	gene	1.00
CANCER	regulates	gene	1.00
MDM2	binds_to	protein	0.95
STAU1	activates	protein	0.90
SNORA13	upstream_of	process	0.90
MDM2 antagonist Nutlin-3	activates	drug	0.90
APR-246	activates	drug	0.90
DRAGO (KIAA0247)	cooperates_with	gene	0.90
ribosomal proteins	activates	protein	0.90
MDM2	interacts_with	protein	0.90
POLY(PR)	activates	protein	0.90
RBM28	binds	protein	0.90
MDM2	regulates	gene	0.90
CANCER	treats	gene	0.90
GPX4	activates	gene	0.90
AMPK	activates	gene	0.90
TP53	activates	gene	0.90
GENES	activates	gene	0.90
TNF	inhibits	gene	0.90
PI3K	regulates	gene	0.90
PARKINSON	activates	gene	0.90
NEURODEGENERATION	regulates	gene	0.90
STAT3	activates	gene	0.90
PARKINSON'S DISEASE	activates	gene	0.90

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PARP1 Inhibition Blocks Poly(PR)-Triggered DNA Damage and Su	0.661	neurodegeneration	What upstream mechanisms trigger p53 act

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

P53

Understanding Entity Pages

Summary

Wiki Pages (6)

TIGAR - TP53-Induced Glycolysis and Apoptosis Regulator

DJ-1-PTEN-P53 Network

TP53 Gene

TIGAR Protein — TP53-Induced Glycolysis and Apoptosis Regulator

TP53 Protein (p53)

Tumor Protein P53