gene

CDK4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

409Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CDK4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with Als, Autism, Breast Cancer. Connected to 264 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CDK4
Full Name	Cyclin-Dependent Kinase 4
Chromosome	12q14.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	34 kDa
Amino Acids	303 aa
Exons	8
Pathways	Akt, Dna Methylation, Epigenetic, Pi3K
UniProt ID	P11802
NCBI Gene ID	1019
Ensembl ID	ENSG00000136492
GeneCards	CDK4
Human Protein Atlas	CDK4
Associated Diseases	Als, Cancer, Carcinoma, glioblastoma, Melanoma
Interactions	ACTB, AKT, AND, APOPTOSIS, ARAF, ATF4
KG Connections	409 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CDK4 — AlphaFold P11802 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CDK4 Gene

gene · 815 words

→

CDK4 Protein

protein · 643 words

→

Pathway Diagram

graph TD
    CDK4["CDK4"]
    CDK4 -->|"interacts"| RB1["RB1"]
    CDK4 -->|"activates"| Cancer["Cancer"]
    CDK4 -->|"activates"| Als["Als"]
    CDK4 -->|"activates"| Senescence["Senescence"]
    CDK4 -->|"activates"| Inflammation["Inflammation"]
    CDK4 -->|"activates"| Tumor["Tumor"]
    CDK4 -->|"regulates"| Ms["Ms"]
    RANK["RANK"] -->|"activates"| CDK4
    RANKL["RANKL"] -->|"activates"| CDK4
    FGFR1["FGFR1"] -->|"target for"| CDK4
    SOX2["SOX2"] -->|"target for"| CDK4
    MYC["MYC"] -->|"regulates"| CDK4
    EBF3["EBF3"] -->|"regulates"| CDK4
    RB1 -->|"regulates"| CDK4
    GBM["GBM"] -->|"regulates"| CDK4

Outgoing (243)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CDK4	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Cancer	activates	disease	0.95
Cancer	therapeutic_target	disease	0.95
Als	inhibits	disease	0.85
Tumor	activates	disease	0.85
Als	activates	disease	0.85
Melanoma	associated_with	disease	0.75
Tumor	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
Cancer	inhibits	disease	0.75
Als	associated_with	disease	0.75
POT1	associated_with	gene	0.70
MTOR	therapeutic_target	gene	0.70
Autophagy	activates	pathway	0.70
AKT	therapeutic_target	gene	0.70
glioblastoma	associated_with	disease	0.70
Mtor	therapeutic_target	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
Cell Cycle	therapeutic_target	pathway	0.70
RB1	interacts_with	protein	0.70
Apoptosis	activates	pathway	0.70
Lung Cancer	activates	disease	0.65
Senescence	regulates	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ovarian Cancer	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Pancreatic Cancer	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Senescence	inhibits	disease	0.65
Als	regulates	disease	0.65
Migraine	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Glioblastoma	regulates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Ms	regulates	disease	0.65
Melanoma	activates	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Als	therapeutic_target	disease	0.65
Ataxia	activates	disease	0.65
ALS	inhibits	disease	0.65
Cancer	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
Carcinoma	associated_with	disease	0.65

Incoming (166)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CDK4	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
CANCER	activates	gene	0.90
CANCER	therapeutic_target	gene	0.90
chromothripsis	upstream_of	process	0.80
PI3K	therapeutic_target	gene	0.80
AUTOPHAGY	activates	gene	0.70
CANCER	inhibits	gene	0.70
CDK6	therapeutic_target	gene	0.70
APOPTOSIS	activates	gene	0.70
CDKN2A	associated_with	gene	0.70
CANCER	associated_with	gene	0.70
GENES	associated_with	gene	0.70
CYCLIN D1	activates	gene	0.60
BCL-2	activates	gene	0.60
AND	therapeutic_target	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	therapeutic_target	gene	0.60
KRAS	therapeutic_target	gene	0.60
CXCL8	regulates	gene	0.60
TP53	regulates	gene	0.60
SRC	regulates	gene	0.60
EZH2	regulates	gene	0.60
SIRT1	regulates	gene	0.60
MCL1	interacts_with	gene	0.60
PI3K	inhibits	gene	0.60
BRAF	inhibits	gene	0.60
P53	therapeutic_target	gene	0.60
CDH1	therapeutic_target	gene	0.60
ROS	activates	gene	0.60
HUNTINGTIN	inhibits	gene	0.60
CYCLIN D1	inhibits	gene	0.60
KRAS	inhibits	gene	0.60
HER2	inhibits	gene	0.60
NEUROTOXICITY	inhibits	gene	0.60
P21	inhibits	gene	0.60
CCND1	interacts_with	gene	0.60
PIK3CA	associated_with	gene	0.60
PARP1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PI3K	regulates	gene	0.60
CHEK1	associated_with	gene	0.60
AKT	regulates	gene	0.60
CASP3	associated_with	gene	0.60
CASP8	interacts_with	gene	0.60
MMP2	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60
GBM	interacts_with	gene	0.60
NOXA	activates	gene	0.60
MDM2	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDK4 in their description or question text

No additional research found