gene

RICTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RICTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

424Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RICTOR is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with ALS, Als, Amyotrophic Lateral Sclerosis. Connected to 237 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RICTOR
Full Name	Raptor Companion
Chromosome	5p13.1
Function	encodes a critical component of the mechanistic target of rapamycin complex 2 (mTORC2), a key signaling hub that regulates cell survival, metabolism, cytoskeletal organization, and synaptic plastic...
Molecular Weight	200 kDa
Amino Acids	708 aa
Pathways	mTOR, mtor, mTOR signaling, MAPK
UniProt ID	Q6R327
NCBI Gene ID	253782
Ensembl ID	ENSG00000164327
OMIM	610027
GeneCards	RICTOR
Human Protein Atlas	RICTOR
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	ACETYL-COA, Actin, AKT, AKT1, AKT1S1, AMBRA1
KG Connections	424 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RICTOR — AlphaFold Q6R327 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    RICTOR["RICTOR
mTORC2 Component"]
    MTOR["MTOR
Mechanistic Target
of Rapamycin"]
    mTORC2["mTORC2
Complex"]
    AKT_pathway["AKT Signaling
Pathway"]
    PI3K_pathway["PI3K/AKT
Pathway"]
    
    PIK3C3["PIK3C3
Autophagy Regulator"]
    Autophagy["Autophagy
Cellular Clearance"]
    AMBRA1["AMBRA1
Autophagy Regulator"]
    FIP200["FIP200
Autophagy Initiator"]
    
    EGFR["EGFR
Growth Factor
Receptor"]
    PPARG["PPARG
Metabolic
Regulator"]
    HSPA5["HSPA5
ER Stress
Response"]
    
    ALS["Amyotrophic
Lateral Sclerosis"]
    MS["Multiple
Sclerosis"]
    Dementia["Dementia"]
    
    RICTOR -->|"forms complex"| mTORC2
    RICTOR -->|"interacts with"| MTOR
    mTORC2 -->|"activates"| AKT_pathway
    AKT_pathway -->|"promotes"| PI3K_pathway
    
    RICTOR -->|"interacts with"| PIK3C3
    PIK3C3 -->|"regulates"| Autophagy
    RICTOR -->|"interacts with"| AMBRA1
    RICTOR -->|"interacts with"| FIP200
    AMBRA1 -->|"promotes"| Autophagy
    FIP200 -->|"initiates"| Autophagy
    
    RICTOR -->|"interacts with"| EGFR
    RICTOR -->|"interacts with"| PPARG
    RICTOR -->|"interacts with"| HSPA5
    
    RICTOR -->|"activates"| ALS
    RICTOR -->|"activates"| MS
    RICTOR -->|"activates"| Dementia
    Autophagy -->|"dysfunction leads to"| ALS
    
    style RICTOR fill:#006494
    style mTORC2 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style Autophagy fill:#1b5e20
    style PIK3C3 fill:#4a1a6b
    style AMBRA1 fill:#4a1a6b
    style FIP200 fill:#4a1a6b
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Dementia fill:#ef5350
    style AKT_pathway fill:#5d4400
    style PI3K_pathway fill:#5d4400

Outgoing (236)

Target	Relation	Type	Str
Als	activates	disease	0.75
AKT	inhibits	gene	0.70
Mtor	activates	pathway	0.70
Cancer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Inflammatory Bowel Disease	inhibits	disease	0.65
Cancer	inhibits	disease	0.65
Fibrosis	interacts_with	disease	0.65
Tumor	inhibits	disease	0.65
Als	inhibits	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
ALS	interacts_with	disease	0.65
Dementia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Als	expressed_in	disease	0.65
Renal Cell Carcinoma	therapeutic_target	disease	0.65
Lymphoma	expressed_in	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	contributes_to	disease	0.65
MTOR	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
YWHAG	activates	gene	0.60
Akt	interacts_with	pathway	0.60
Oxidative Phosphorylation	interacts_with	pathway	0.60
Wnt	interacts_with	pathway	0.60
DNA	interacts_with	gene	0.60
IRS1	regulates	gene	0.60
Mtor	regulates	pathway	0.60
Pi3K	regulates	pathway	0.60
MTORC1	contributes_to	gene	0.60
Mtor	contributes_to	pathway	0.60
GABA	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
GCN2	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
Egfr	interacts_with	protein	0.60
LDHA	inhibits	gene	0.60
AKT	therapeutic_target	gene	0.60

Incoming (188)

Source	Relation	Type	Str
CANCER	phosphorylates	entity	0.60
RAPTOR	expressed_in	gene	0.60
PI3K	therapeutic_target	gene	0.60
ERN1	activates	gene	0.60
PERK	activates	gene	0.60
ENDOG	activates	gene	0.60
AKT	activates	gene	0.60
HSPA5	activates	gene	0.60
TSC2	activates	gene	0.60
GSK3B	activates	gene	0.60
EIF2AK3	activates	gene	0.60
NBR1	phosphorylates	entity	0.60
OPTINEURIN	phosphorylates	entity	0.60
OPTN	phosphorylates	entity	0.60
P38	phosphorylates	entity	0.60
PI3K	phosphorylates	entity	0.60
PIK3C3	phosphorylates	entity	0.60
PPARG	phosphorylates	entity	0.60
RB1CC1	phosphorylates	entity	0.60
RHEB	phosphorylates	entity	0.60
ROS	interacts_with	gene	0.60
MTOR	activates	gene	0.60
MYC	activates	gene	0.60
DEPTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
TSC1	regulates	gene	0.60
MTOR	regulates	gene	0.60
PI3K	regulates	gene	0.60
MTOR	contributes_to	gene	0.60
PIK3C3	activates	gene	0.60
YWHAG	activates	gene	0.60
FOXP3	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
BAX	inhibits	gene	0.60
FAS	inhibits	gene	0.60
LC3	inhibits	gene	0.60
DDIT3	phosphorylates	entity	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RICTOR in their description or question text

No additional research found