gene

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RIPK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RIPK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1590Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

🤖 AI-Generated

RIPK1 - Receptor-interacting serine/threonine-protein kinase 1, a master regulator of necroptosis, apoptosis, and inflammation in neurodegeneration

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🧬 Gene Info

Gene Symbol	RIPK1
Aliases	Receptor-Interacting Serine/Threonine-Protein Kinase 1
Protein Type	Kinase
Function	Complex I formation: TNFR1 recruits TRADD, RIPK1, TRAF2/5, and cIAP1/2 into a membrane-associated complex
Molecular Weight	75 kDa
Amino Acids	671 aa
Exons	9
Pathways	NF-κB signaling, NF-κB
GeneCards	RIPK1
Human Protein Atlas	RIPK1
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Cancer
Known Drugs/Compounds	Cadmium, citronellol, HSYA, metformin, Metformin, Mitochondrial ROS
Interactions	ABCG2, ACHE, Actin, AD, AIF, AIM2
KG Connections	1590 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: RIPK1 — PDB 4ITH Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    RIPK1(["RIPK1"])
    AMPK(["AMPK"])
    INFLAMMATION["INFLAMMATION"]
    Cell_Death("Cell Death")
    Necrostatin{"Necrostatin"}
    Necroptosis["Necroptosis"]
    Inflammation["Inflammation"]
    Inflammatory_Gene_Expression("Inflammatory Gene Expression")
    neuroinflammation("neuroinflammation")
    APOPTOSIS["APOPTOSIS"]
    BAF_COMPLEX(["BAF COMPLEX"])
    citronellol{"citronellol"}
    Apoptosis["Apoptosis"]
    RIPK3(["RIPK3"])

    AMPK -->|"phosphorylates"| RIPK1
    RIPK1 -.->|"inhibits"| INFLAMMATION
    RIPK1 -->|"mediates"| Cell_Death
    RIPK1 -->|"regulates"| Cell_Death
    Necrostatin -.->|"inhibits"| RIPK1
    RIPK1 -->|"involved in"| Necroptosis
    RIPK1 -->|"regulates"| Inflammation
    RIPK1 -->|"upregulates"| Inflammatory_Gene_Expression
    RIPK1 -->|"causes"| neuroinflammation
    RIPK1 -.->|"inhibits"| APOPTOSIS
    RIPK1 -->|"interacts with"| BAF_COMPLEX
    citronellol -->|"activates"| RIPK1
    RIPK1 -->|"regulates"| Apoptosis
    RIPK1 -->|"regulates"| Necroptosis
    RIPK3 -->|"regulates"| RIPK1

    style RIPK1 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (848)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:RIPK1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Caspase-8-mediated Apoptosis	mediates	process	0.95
neuroinflammation	regulates	process	0.95
PANoptosis	component_of	process	0.95
PANoptosome	component_of	structure	0.95
necroinflammation	mediates	process	0.95
PANoptosis	drives	process	0.95
Necroptosis	mediates	process	0.95
Necroptosis	component_of	pathway	0.95
Neuroinflammation	associated_with	process	0.95
Inflammation	mediates	process	0.95
Axonal Degeneration	mediates	process	0.95
hepatic apoptosis	promotes	process	0.93
caspase-8	activates	protein	0.92
necroptosis	participates_in	pathway	0.90
Cell Death	mediates	process	0.90
Cell Death	regulates	process	0.90
oxidative stress response	participates_in	pathway	0.90
Necroinflammation	involved_in	process	0.90
necroptosis	associated_with	process	0.90
Neuroinflammation	mediates	process	0.90
Apoptosis	mediates	process	0.90
inflammation	associated_with	process	0.90
TRIF	inhibits	protein	0.90
Steatotic Liver Ischemia/Reperfusion Injury	contributes_to	disease	0.90
TNF-INDUCED CELL DEATH	mediates	biological_process	0.90
Caspase-8-Mediated Apoptosis	associated_with	process	0.90
RHIM domain-dependent antiviral transcription	mediates	process	0.90
depression	promotes	disease	0.90
Cytokines	upregulates	compound	0.90
Pyroptosis	mediates	process	0.90
PANoptosis	regulates	process	0.90
neuroinflammation	mediates	process	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
SOD1(G93A)-MEDIATED ALS	mediates	disease	0.88
Alzheimer's Disease	therapeutic_target	disease	0.88
JAK1	interacts_with	gene	0.88
Lytic Cell Death	mediates	process	0.88
Proinflammatory Mediators	upregulates	process	0.88
Necroptosis	associated_with	process	0.87
Toll-Like Receptors	upregulates	receptor	0.87
Tdp-43 Pathology	promotes	phenotype	0.85
Cytokines	regulates	protein	0.85
ANTITUMOR IMMUNITY	promotes	biological_process	0.85
DAMP RELEASE	mediates	biological_process	0.85
Chromatin Modification	upregulates	process	0.85
Lytic Cell Death	associated_with	process	0.85
DAMPs	associated_with	compound	0.85
Apoptosis	associated_with	process	0.85

Incoming (742)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:RIPK1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
PARP5A	interacts_with	protein	0.95
Ponicidin	binds	compound	0.95
RUBCNL	interacts_with	protein	0.95
RNF146	interacts_with	protein	0.95
AMPK	phosphorylates	protein	0.95
RUBCNL	inhibits	protein	0.90
Necrostatin	inhibits	drug	0.90
Cadmium	activates	compound	0.90
PARP12	associated_with	gene	0.90
ZBP1	interacts_with	protein	0.90
Nec-1s	inhibits	drug	0.90
RNF146	regulates	protein	0.90
PARP5A	PARylates and ubiquitinates	gene	0.90
PARP5A	regulates	protein	0.90
Palmitoylation	activates	process	0.90
Metformin	inhibits	drug	0.88
Mitochondrial ROS	activates	compound	0.85
PARP5A	phosphorylates	protein	0.85
RNF146	ubiquitinates	protein	0.85
PARP5A	modulates	protein	0.85
HSYA	binds	compound	0.85
Musk	inhibits	drug	0.80
THSG	inhibits	compound	0.80
citronellol	activates	drug	0.80
metabolic pathway	modulates	pathway	0.80
Tnf-Α	inhibits	protein	0.80
EPILEPSY	associated_with	gene	0.80
DHHC5	phosphorylates	protein	0.80
INFLAMMATION	activates	gene	0.80
RIPK3	regulates	gene	0.80
INFLAMMATION	regulates	gene	0.80
OPTN	inhibits	gene	0.72
NEURONS	interacts_with	cell_type	0.70
NECROPTOSIS	activates	pathway	0.70
NECROPTOSIS	regulates	pathway	0.70
MACROPHAGE	expresses	cell_type	0.70
ENDOTHELIAL	activates	cell_type	0.70
MLKL	protects_against	gene	0.70
MULTIPLE SCLEROSIS	associated_with	disease	0.70
MICROGLIA	enhances	cell_type	0.70
NEURONS	activates	cell_type	0.70
ENDOTHELIAL	degrades	cell_type	0.70
NECROPTOSIS	mediates	pathway	0.70
NFKB	activates	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.70
AMPK	protects_against	gene	0.70
NEURONS	expresses	cell_type	0.70
MLKL	causes	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RIPK1 in their description or question text

No additional research found

RIPK1

Understanding Entity Pages

Summary

Wiki Pages (11)

RIPK1

RIPK1 Inhibitor Therapy

CASS2 — CASP2 and RIPK1 Domain Containing Adaptor

RIPK1 Gene

RIPK1 Inhibitor Therapy in Neurodegeneration

RIPK1 Inhibitor Therapy

RIPK1 (Receptor-Interacting Kinase 1)

RIPK1 Inhibitors for Neurodegeneration

RIPK1-TAK1 Interaction Inhibitor

RIPK1 Inhibitors in Neurodegeneration

RIPK1 Protein

Pathway Diagram

Outgoing (848)

Incoming (742)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Experiments (0)

Related Papers (0)

Debates (0)

Related Research