concept

CDH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

501Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CDH1 is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, therapeutic target. Associated with ALS, Aging, Als. Connected to 387 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CDH1
Key Genes/Proteins	ABCB1, Actin, ADRB1, AGING, AKK, AKT1
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Akt, AKT

Wiki Pages (8)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CDH1["CDH1"]
    CDH1 -->|"interacts"| Cancer["Cancer"]
    CDH1 -->|"regulates"| Fibrosis["Fibrosis"]
    CDH1 -->|"interacts"| Als["Als"]
    CDH1 -->|"interacts"| Ms["Ms"]
    CDH1 -->|"activates"| Aging["Aging"]
    CMVS["CMVS"] -->|"activates"| CDH1
    GABARAP["GABARAP"] -->|"interacts"| CDH1
    P38["P38"] -->|"interacts"| CDH1
    PIK3C3["PIK3C3"] -->|"interacts"| CDH1
    AKT1["AKT1"] -->|"regulates"| CDH1
    DDIT3["DDIT3"] -->|"interacts"| CDH1
    IFNG["IFNG"] -->|"interacts"| CDH1
    PI3K["PI3K"] -->|"interacts"| CDH1

Outgoing (290)

Target	Relation	Type	Str
APC/C(CDH1)	component_of	protein	0.95
Cancer	activates	disease	0.85
Anapc11	interacts_with	protein	0.85
Carcinoma	causes	disease	0.75
Als	activates	disease	0.75
Cancer	associated_with	disease	0.75
Tumor	activates	disease	0.75
Carcinoma	activates	disease	0.75
PI3K	regulates	pathway	0.70
Hippo	regulates	pathway	0.70
TAZ	regulates	protein	0.70
AKT	regulates	pathway	0.70
beta-catenin	regulates	protein	0.70
YAP	regulates	protein	0.70
CANCER	activates	gene	0.70
APC	regulates	gene	0.70
APC	activates	gene	0.70
Ms	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Schizophrenia	activates	disease	0.65
Fibrosis	regulates	disease	0.65
Ms	activates	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	activates	disease	0.65
Infection	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Carcinoma	biomarker_for	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Tumor	causes	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Colorectal Cancer	causes	disease	0.65
Cancer	regulates	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Aging	regulates	disease	0.65
Cancer	biomarker_for	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65

Incoming (211)

Source	Relation	Type	Str
Byf	upregulates	drug	0.95
FZR1	encodes	gene	0.95
Thermal Adaptation	upregulates	process	0.90
Thermal adaptation	upregulates	process	0.85
CMVS	activates	protein	0.72
CANCER	activates	gene	0.70
G6PD	protects_against	gene	0.60
JUN	activates	gene	0.60
MMP9	expressed_in	gene	0.60
NRCAM	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
EGF	expressed_in	gene	0.60
FOXM1	regulates	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
LEF1	therapeutic_target	gene	0.60
SMARCA4	regulates	gene	0.60
TERT	therapeutic_target	gene	0.60
APC	activates	gene	0.60
AKK	regulates	gene	0.60
CD4	regulates	gene	0.60
CFTR	regulates	gene	0.60
ERN1	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
ATM	regulates	gene	0.60
TP53	regulates	gene	0.60
NBN	regulates	gene	0.60
CANCER	regulates	gene	0.60
CHEK2	regulates	gene	0.60
VEGFA	therapeutic_target	gene	0.60
STK11	regulates	gene	0.60
PTEN	regulates	gene	0.60
BRCA1	regulates	gene	0.60
PALB2	regulates	gene	0.60
HIPPO	inhibits	gene	0.60
BRIP1	regulates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
NTRK3	associated_with	gene	0.60
HIPPO	therapeutic_target	gene	0.60
RHOA	associated_with	gene	0.60
MEF2C	activates	gene	0.60
NF2	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
RHOA	activates	gene	0.60
TP53	activates	gene	0.60
CANCER	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDH1 in their description or question text

No additional research found

CDH1

Understanding Entity Pages

Summary

Wiki Pages (8)

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PCDH19 Family Network

PCDH19

PCDH19-Related Epilepsy (EFMR) — Preclinical Gene Therapy Program Landscape

PCDH19 Alliance