Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EFNB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
EFNB2 (Ephrin B2) is a transmembrane ligand for EPH receptors that mediates cell-cell communication in neural development, synaptic plasticity, and is implicated in Alzheimer's and Parkinson's disease.
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| Gene Symbol | EFNB2 |
| Full Name | Ephrin B2 |
| Protein Type | Receptor |
| Function | is a transmembrane ligand for the Eph family of receptor tyrosine kinases. |
| Molecular Weight | 38 kDa |
| Amino Acids | 333 aa |
| Pathways | Cerebrovascular Development |
| Ensembl ID | ENSG00000145088 |
| GeneCards | EFNB2 |
| Human Protein Atlas | EFNB2 |
| Ephrin A ligands (EFNA1-5) | GPI-anchored |
| Ephrin B ligands (EFNB1-3) | transmembrane |
| Receptor-binding domain | interacts with Eph receptors |
| Conserved cysteine-rich region | maintains structural integrity |
| Cleavage site | can be proteolytically processed |
| Associated Diseases | Congenital Cerebrovascular Disease, Vein Of Galen Malformation |
| Known Drugs/Compounds | Icariin |
| Interactions | EPHB4, GFAP, GRB2, NFKB1 |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
EFNB2["EFNB2"]
EFNB2 -->|"regulates"| Osteoporosis["Osteoporosis"]
EFNB2 -->|"inhibits"| Cancer["Cancer"]
EFNB2 -->|"inhibits"| NFKB1["NFKB1"]
EFNB2 -->|"expressed in"| IL30["IL30"]
EFNB2 -->|"implicated in"| neurodegeneration["neurodegeneration"]
Icariin["Icariin"] -->|"modulates"| EFNB2
EGF["EGF"] -->|"expressed in"| EFNB2
HGF["HGF"] -->|"expressed in"| EFNB2
CCL2["CCL2"] -->|"expressed in"| EFNB2
VEGFA["VEGFA"] -->|"expressed in"| EFNB2
CDH1["CDH1"] -->|"expressed in"| EFNB2
ANG["ANG"] -->|"expressed in"| EFNB2
PLG["PLG"] -->|"expressed in"| EFNB2| Target | Relation | Type | Str |
|---|---|---|---|
| EPHB4 | interacts_with | gene | 0.95 |
| Cerebrovascular Development | involved_in | process | 0.90 |
| Osteoporosis | regulates | disease | 0.85 |
| Vein Of Galen Malformation | associated_with | disease | 0.85 |
| Congenital Cerebrovascular Disease | associated_with | disease | 0.80 |
| Glucocorticoid-Induced Osteoporosis | contributes_to | disease | 0.80 |
| GRB4 | regulates | gene | 0.80 |
| GRB2 | activates | gene | 0.75 |
| Cancer | inhibits | disease | 0.65 |
| NFKB1 | inhibits | gene | 0.60 |
| IL30 | expressed_in | gene | 0.60 |
| DAM microglia | expressed_in | cell_type | 0.55 |
| astrocytes | expressed_in | cell_type | 0.55 |
| GFAP | activates | gene | 0.55 |
| neurons | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Icariin | downregulates | compound | 0.90 |
| EPHB4 | interacts_with | gene | 0.85 |
| Glucocorticoid | upregulates | drug | 0.80 |
| Icariin | modulates | compound | 0.80 |
| Somatic Mosaicism | mediates | mechanism | 0.75 |
| EGF | expressed_in | gene | 0.60 |
| VEGFA | expressed_in | gene | 0.60 |
| ANG | expressed_in | gene | 0.60 |
| PLG | expressed_in | gene | 0.60 |
| PTEN | expressed_in | gene | 0.60 |
| HGF | expressed_in | gene | 0.60 |
| CCL2 | expressed_in | gene | 0.60 |
| CDH1 | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning EFNB2 in their description or question text
No additional research found