gene

SRC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1115Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

SRC is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with AD, ALI, ALS. Connected to 671 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SRC
Protein Type	Receptor
Function	SRC encodes a member of the Src family of non-receptor tyrosine kinases (SFKs).
Pathways	Apoptosis, Autophagy, Complement, Dendritic Spine, Differentiation
Ensembl ID	ENSG00000197122
GeneCards	SRC
Human Protein Atlas	SRC
Associated Diseases	AD, ALI, Als, Alzheimer, Autism
Known Drugs/Compounds	DEP, DOP
Interactions	ABL1, ACE, ACSL4, AD, ADRB2, AGING
KG Connections	1113 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SRC Gene

gene · 800 words

→

SRC Protein (SRC Proto-Oncogene)

protein · 2125 words

→

Pathway Diagram

flowchart TD
    SRC(["SRC"])
    Cancer["Cancer"]
    Tumor["Tumor"]
    Als["Als"]
    EGFR(["EGFR"])
    CANCER(["CANCER"])
    Apoptosis["Apoptosis"]
    AKT(["AKT"])
    APOPTOSIS(["APOPTOSIS"])
    ARHGEF7(["ARHGEF7"])
    ERK(["ERK"])
    RELN["RELN"]

    SRC -->|"activates"| Cancer
    SRC -->|"activates"| Tumor
    SRC -->|"therapeutic target"| Cancer
    SRC -->|"activates"| Als
    EGFR -->|"activates"| SRC
    CANCER -->|"activates"| SRC
    SRC -->|"activates"| Apoptosis
    AKT -->|"activates"| SRC
    CANCER -->|"therapeutic target"| SRC
    APOPTOSIS -->|"activates"| SRC
    SRC -->|"therapeutic target"| Tumor
    SRC -->|"phosphorylates"| ARHGEF7
    SRC -->|"activates"| ERK
    SRC -->|"interacts with"| RELN
    AKT -->|"therapeutic target"| SRC

    style SRC fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (667)

Target	Relation	Type	Str
Als	activates	disease	1.00
Cancer	activates	disease	1.00
Tumor	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Apoptosis	activates	pathway	1.00
Tumor	therapeutic_target	disease	0.95
RELN	interacts_with	entity	0.90
endocrine therapy resistance	promotes	phenotype	0.90
ERK	activates	protein	0.90
Als	therapeutic_target	disease	0.85
NEURONAL MIGRATION	involved_in	entity	0.85
Inflammation	inhibits	disease	0.85
MAPK14	interacts_with	gene	0.80
ANT1	phosphorylates	protein	0.80
Glycolysis	activates	pathway	0.80
Apoptosis	therapeutic_target	pathway	0.80
Invasion	activates	pathway	0.80
Metastasis	activates	pathway	0.80
Als	regulates	disease	0.75
Carcinoma	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Inflammation	activates	disease	0.75
Cancer	inhibits	disease	0.75
Tumor	regulates	disease	0.75
Tumor	associated_with	disease	0.75
Cancer	regulates	disease	0.75
Als	interacts_with	disease	0.75
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.75
Cancer	associated_with	disease	0.75
Carcinoma	activates	disease	0.75
Fibrosis	therapeutic_target	disease	0.75
Cancer	interacts_with	disease	0.75
Traumatic Brain Injury	inhibits	disease	0.75
Carcinoma	interacts_with	disease	0.75
Tumor	interacts_with	disease	0.75
Angiogenesis	therapeutic_target	pathway	0.70
MTOR	regulates	gene	0.70
Oxidative Stress	inhibits	pathway	0.70
Necroptosis	activates	pathway	0.70
Mapk	activates	pathway	0.70
MTOR	activates	gene	0.70
Oxidative Stress	therapeutic_target	pathway	0.70
JAK-STAT signaling	participates_in	pathway	0.70
Pi3K/Akt	activates	pathway	0.70
Pi3K/Akt	regulates	pathway	0.70
Nf-Κb	inhibits	pathway	0.70
Cell Cycle	activates	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Mtor	regulates	pathway	0.70

Incoming (448)

Source	Relation	Type	Str
TMEM16F	regulates	gene	1.00
EGFR	activates	gene	1.00
CANCER	activates	gene	1.00
AKT	activates	gene	1.00
CANCER	therapeutic_target	gene	1.00
APOPTOSIS	activates	gene	1.00
fatty acid β-oxidation	activates	pathway	0.93
DOP	binds	compound	0.90
PI3K	therapeutic_target	gene	0.90
AKT	therapeutic_target	gene	0.90
DEP	binds	compound	0.85
VLDLR	activates	protein	0.85
Glutamate	activates	compound	0.85
PTK2	activates	gene	0.82
PI3K	activates	gene	0.80
AKT	regulates	gene	0.80
TP53	therapeutic_target	gene	0.80
TUBB3	activates	gene	0.75
PIEZO1	activates	gene	0.74
PTEN	activates	gene	0.70
CANCER	regulates	gene	0.70
STAT3	activates	gene	0.70
PI3K	regulates	gene	0.70
EGFR	interacts_with	gene	0.70
EGF	activates	gene	0.70
AMPK	activates	gene	0.70
ESR1	therapeutic_target	gene	0.70
AKT1	interacts_with	gene	0.70
EGFR	therapeutic_target	gene	0.70
ERK	activates	gene	0.70
GENES	interacts_with	gene	0.70
JAK	activates	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
RAS	activates	gene	0.70
ALS	therapeutic_target	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.70
INFLAMMATION	inhibits	gene	0.70
CANCER	associated_with	gene	0.70
YAP	activates	gene	0.70
CYTOKINES	inhibits	gene	0.70
MAPK	interacts_with	gene	0.65
FYN	causes	gene	0.65
GLIOBLASTOMA	phosphorylates	disease	0.65
CANCER	phosphorylates	disease	0.65
ERK	phosphorylates	gene	0.65
JAK	phosphorylates	gene	0.65
IL6	activates	protein	0.64
FYN	activates	gene	0.60
LCK	activates	gene	0.60
EFNB1	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD44-Mediated Src/PI3K/Akt Signaling Cascade	0.470	neuroinflammation	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity