gene

TTR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TTR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

1Hypotheses

0Analyses

38Outgoing

25Incoming

0Experiments

0Debates

Summary

TTR is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, associated with. Associated with Als, Inflammation, Ms. Connected to 35 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TTR
Full Name	Transthyretin
Chromosome	18q12.1.
Function	Under normal conditions, TTR functions as
Primary Expression	Liver, Choroid plexus, Retinal pigment epithelium, Pancreas
Molecular Weight	55 kDa
Amino Acids	127 aa
UniProt ID	P02766
NCBI Gene ID	7276
Ensembl ID	ENSG00000118271
OMIM	176300
GeneCards	TTR
Human Protein Atlas	TTR
Associated Diseases	Als, hereditary polyneuropathies, Hereditary Polyneuropathy, Ms
Interactions	AKT1, ALZHEIMER, AMYLOID, APP, AQP1, CYTOKINES
KG Connections	63 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TTR — AlphaFold P02766 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TTR["TTR"]
    GABRD["GABRD"]
    TTR -->|"regulates"| GABRD
    Inflammation{"Inflammation"}
    TTR -->|"therapeutic target"| Inflammation
    Als{"Als"}
    TTR -->|"therapeutic target"| Als
    TTR -->|"associated with"| Als
    Ms{"Ms"}
    TTR -->|"associated with"| Ms
    TTR -->|"therapeutic target"| Ms
    LGALS3["LGALS3"]
    TTR -->|"therapeutic target"| LGALS3
    CTSD["CTSD"]
    TTR -->|"therapeutic target"| CTSD
    GRB2["GRB2"]
    TTR -->|"therapeutic target"| GRB2
    TLR4["TLR4"]
    TTR -->|"therapeutic target"| TLR4
    NFE2L2["NFE2L2"]
    TTR -->|"therapeutic target"| NFE2L2
    RPS6KA1["RPS6KA1"]
    TTR -->|"therapeutic target"| RPS6KA1
    GENES["GENES"]
    GENES -->|"therapeutic target"| TTR
    CAPN1["CAPN1"]
    CAPN1 -->|"therapeutic target"| TTR
    ERK["ERK"]
    ERK -->|"associated with"| TTR
    PIK3CA["PIK3CA"]
    PIK3CA -->|"interacts with"| TTR
    MMP9["MMP9"]
    MMP9 -->|"interacts with"| TTR
    PPARA["PPARA"]
    PPARA -->|"interacts with"| TTR
    IGF1R["IGF1R"]
    IGF1R -->|"interacts with"| TTR
    RELA["RELA"]
    RELA -->|"interacts with"| TTR
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| TTR
    INSR["INSR"]
    INSR -->|"interacts with"| TTR
    style TTR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
Hereditary Polyneuropathies	implicated_in	disease	0.95
Hereditary Polyneuropathy	causes	disease	0.90
hereditary polyneuropathies	implicated_in	disease	0.90
GABRD	regulates	gene	0.80
Dementia	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	inhibits	disease	0.65
Depression	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Apoptosis	therapeutic_target	pathway	0.60
MMP2	interacts_with	gene	0.60
SLC2A1	interacts_with	gene	0.60
Neurogenesis	expressed_in	pathway	0.60
PPARG	interacts_with	gene	0.60
ESR1	interacts_with	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
CTSD	therapeutic_target	gene	0.60
TAU	inhibits	gene	0.60
TLR4	therapeutic_target	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
RPS6KA1	therapeutic_target	gene	0.60
HIF1A	therapeutic_target	gene	0.60
GRIN1	therapeutic_target	gene	0.60
ADAM10	therapeutic_target	gene	0.60
GRB2	therapeutic_target	gene	0.60
MAPK1	therapeutic_target	gene	0.60
neurodegeneration	expressed_in	disease	0.60
LGALS3	therapeutic_target	gene	0.60
Akt	interacts_with	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
CYTOKINES	inhibits	gene	0.60
DEMENTIA	inhibits	gene	0.60

Incoming (25)

Source	Relation	Type	Str
PIK3CA	interacts_with	gene	0.60
MMP9	interacts_with	gene	0.60
PPARA	interacts_with	gene	0.60
IGF1R	interacts_with	gene	0.60
RELA	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CX32	causes	gene	0.60
GJB1	causes	gene	0.60
ERK	associated_with	gene	0.60
INSR	interacts_with	gene	0.60
MFN2	causes	gene	0.60
GENES	therapeutic_target	gene	0.60
EGR2	causes	gene	0.60
RNA	inhibits	gene	0.60
MPZ	causes	gene	0.60
PMP22	causes	gene	0.60
FYN	therapeutic_target	gene	0.60
APP	inhibits	gene	0.60
BRAF	therapeutic_target	gene	0.60
DEPRESSION	inhibits	gene	0.60
ROS	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
CAPN1	therapeutic_target	gene	0.60
AQP1	activates	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Telomere Attrition and DNA Damage Response Activation Induce	0.520	neurodegeneration	What molecular mechanisms drive microgli

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TTR in their description or question text

No additional research found

TTR