gene

EGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1011Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Epidermal Growth Factor gene - a neurotrophic factor implicated in neuronal survival, neuroprotection, and neurodegenerative diseases including Alzheimer's and Parkinson's.

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🧬 Gene Info

Gene Symbol	EGF
Full Name	Epidermal Growth Factor
Aliases	Epidermal Growth Factor gene
Chromosome	4q25
Function	is a type I transmembrane protein that can be proteolytically cleaved at multiple sites to release the mature growth factor.
Molecular Weight	6.2 kDa
Amino Acids	53 aa
Exons	24
Pathways	MAPK, PI3K
UniProt ID	P01133
NCBI Gene ID	1167
Ensembl ID	ENSG00000138798
OMIM	131530
GeneCards	EGF
Human Protein Atlas	EGF
Associated Diseases	Aging, Als, Atherosclerosis, Cancer, Carcinoma
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT, AKT1, AKT1S1, ALDH1L1, ALZHEIMER'S DISEASE
KG Connections	1011 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EGF — AlphaFold P01133 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Alzheimer's Disease VEGF/Angiogenic Signaling and Cerebral Blood Flow Therapy Companies

company · 2020 words

→

PD EGFR and Receptor Tyrosine Kinase Therapeutic Companies

company · 1817 words

→

Pathway Diagram

flowchart TD
    EGF(["EGF"])
    Cancer["Cancer"]
    Als["Als"]
    Tumor["Tumor"]
    CANCER(["CANCER"])
    Nrf2["Nrf2"]
    AKT(["AKT"])
    EGFR(["EGFR"])
    RAS(["RAS"])
    Carcinoma["Carcinoma"]
    Egfr_Signaling["Egfr Signaling"]

    EGF -->|"activates"| Cancer
    EGF -->|"activates"| Als
    EGF -->|"activates"| Tumor
    CANCER -->|"activates"| EGF
    EGF -->|"expressed in"| Tumor
    Nrf2 -->|"upregulates"| EGF
    EGF -->|"activates"| AKT
    EGFR -->|"activates"| EGF
    RAS -->|"activates"| EGF
    EGF -->|"interacts with"| Als
    EGF -->|"activates"| Carcinoma
    EGF -->|"therapeutic target"| Cancer
    EGF -->|"activates"| EGFR
    EGF -->|"interacts with"| EGFR
    EGF -->|"activates"| Egfr_Signaling

    style EGF fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (676)

Target	Relation	Type	Str
Cancer	activates	disease	1.00
Als	activates	disease	1.00
Tumor	activates	disease	1.00
Tumor	expressed_in	disease	0.95
AKT	activates	gene	0.90
Als	interacts_with	disease	0.85
PIF	inhibits	protein	0.85
Carcinoma	activates	disease	0.85
Cancer	therapeutic_target	disease	0.85
EGFR	activates	protein	0.82
oxidative stress response	participates_in	pathway	0.80
stem cells	expressed_in	cell_type	0.80
Neuroregulin Signaling	activates	pathway	0.80
stem cells	supports	cell_type	0.80
neural stem cells	activates	cell_type	0.80
neural stem cells	regulates	cell_type	0.80
Egfr Signaling	activates	pathway	0.80
EGFR	interacts_with	gene	0.80
Cancer	associated_with	disease	0.75
Cancer	regulates	disease	0.75
Cancer	expressed_in	disease	0.75
Glioblastoma	activates	disease	0.75
Inflammation	activates	disease	0.75
Tumor	therapeutic_target	disease	0.75
PDGF	associated_with	gene	0.70
ULK1	activates	gene	0.70
ULK1	interacts_with	gene	0.70
NFKB	activates	gene	0.70
JAK-STAT signaling	participates_in	pathway	0.70
Receptor Tyrosine Kinase	activates	pathway	0.70
EGFR	expressed_in	gene	0.70
PDK1	activates	gene	0.70
endothelial cells	expressed_in	cell_type	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
CANCER	activates	gene	0.70
Apoptosis	activates	pathway	0.70
Endocytosis	activates	pathway	0.70
Mapk	activates	pathway	0.70
Erk Signaling	activates	pathway	0.70
PI3K	regulates	gene	0.70
EGFR	therapeutic_target	gene	0.70
MYC	activates	gene	0.70
SRC	activates	gene	0.70
Multiple Sclerosis	biomarker_for	disease	0.65
Cirrhosis	activates	disease	0.65
Senescence	biomarker_for	disease	0.65
Carcinoma	associated_with	disease	0.65
Parkinson	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Fibrosis	regulates	disease	0.65

Incoming (335)

Source	Relation	Type	Str
EGFR	associated_with	gene	1.00
CANCER	activates	gene	1.00
Nrf2	upregulates	entity	0.95
NFE2L2	upregulates	gene	0.91
NRF2	upregulates	gene	0.90
RAS	activates	gene	0.90
EGFR	activates	gene	0.90
CANCER	therapeutic_target	gene	0.80
ERK	activates	gene	0.80
ASTROCYTE	expressed_in	cell_type	0.70
BECN1	regulates	gene	0.70
AMPK	activates	gene	0.70
CCL2	regulates	gene	0.70
CREB	interacts_with	gene	0.70
CREB	regulates	gene	0.70
ATG7	activates	gene	0.70
CANCER	regulates	gene	0.70
YAP	activates	gene	0.70
ENDOSOMES	activates	gene	0.70
BAX	expressed_in	gene	0.70
HIPPO	activates	gene	0.70
CANCER	associated_with	gene	0.70
rapamycin	targets	drug	0.70
APOPTOSIS	activates	gene	0.70
IL-6	activates	gene	0.70
GENES	expressed_in	gene	0.70
KRAS	activates	gene	0.70
EGFR	therapeutic_target	gene	0.70
PI3K	activates	gene	0.70
PI3K	therapeutic_target	gene	0.70
MIRNAS	interacts_with	gene	0.70
NAFLD	regulates	disease	0.65
STEM CELLS	activates	cell_type	0.65
NRF2	activates	protein	0.64
CALCOCO2	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
EIF2A	interacts_with	gene	0.60
KEAP1	activates	gene	0.60
TFEB	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Cerebral VSMC foam cells induce pericyte detachment via PDGF	0.473	neurodegeneration	How does P2RY12-mediated VSMC dysfunctio
Moderate hyperoxia (1.5-2.0 ATA) optimally stabilizes HIF-1α	0.470	neurodegeneration	What are the optimal oxygen pressure, du

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EGF in their description or question text

No additional research found

EGF

Understanding Entity Pages

Summary

Wiki Pages (21)

EGF Gene

VEGF/Angiogenesis Pathway in Neurodegeneration

EGFR Signaling in Parkinson's Disease

VEGF Signaling and Cerebral Angiogenesis in Neurodegeneration

Alzheimer's Disease VEGF/Angiogenic Signaling and Cerebral Blood Flow Therapy Companies

PD EGFR and Receptor Tyrosine Kinase Therapeutic Companies

NEURD1 - N-terminal EGF Like Domain Calcium Binding Protein 1

VEGF and Angiogenesis Dysregulation in CBS/PSP

EGFR — Epidermal Growth Factor Receptor

PD EGFR Signaling Therapy Companies

Parkinson's Disease EGFR Signaling Therapy Companies

Parkinson's Disease EGFR Signaling Therapy Companies

Pericyte PDGFR/VEGFR Modulator Therapy for Neurodegeneration

VEGF Angiogenesis Therapy for Parkinson's Disease

VEGFR1 (FLT1) Protein

Parkinson's Disease VEGF/Angiogenic Signaling Therapy Companies

Vascular Endothelial Growth Factor (VEGF)

VEGF (Vascular Endothelial Growth Factor)

VEGF and Angiogenesis Therapy

VEGFA — Vascular Endothelial Growth Factor A

VEGFB Protein