concept

KRAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KRAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

951Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

KRAS is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, inhibits. Associated with AD, ARM, Aging. Connected to 440 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	KRAS
Key Genes/Proteins	ACC, ACETYL-COA, AGING, AKT, AKT1, AKT3
Related Diseases	AD, Aging, Als, ALS, Alzheimer
Related Pathways	Akt

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Krasue Inc.

institution · 877 words

→

Pathway Diagram

graph TD
    KRAS["KRAS"]
    KRAS -->|"inhibits"| Cancer["Cancer"]
    KRAS -->|"target for"| Carcinoma["Carcinoma"]
    KRAS -->|"inhibits"| Tumor["Tumor"]
    KRAS -->|"activates"| Als["Als"]
    KRAS -->|"activates"| Ms["Ms"]
    PRMT1["PRMT1"] -->|"inhibits"| KRAS
    VDAC1["VDAC1"] -->|"expressed in"| KRAS
    DRP1["DRP1"] -->|"activates"| KRAS
    DNM1L["DNM1L"] -->|"activates"| KRAS
    GABARAP["GABARAP"] -->|"activates"| KRAS
    WIPI2["WIPI2"] -->|"activates"| KRAS
    P38["P38"] -->|"activates"| KRAS
    BRAF["BRAF"] -->|"regulates"| KRAS
    AKT["AKT"] -->|"activates"| KRAS
    NFE2L2["NFE2L2"] -->|"activates"| KRAS

Outgoing (659)

Target	Relation	Type	Str
CANCER	inhibits	gene	1.00
Colorectal Cancer	activates	disease	1.00
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
CANCER	associated_with	gene	1.00
Carcinoma	activates	disease	1.00
Tumor	activates	disease	1.00
Tumor	associated_with	disease	1.00
Cancer	associated_with	disease	1.00
TP53	associated_with	gene	1.00
Cancer	activates	disease	1.00
CANCER	activates	gene	1.00
Als	activates	disease	1.00
Cancer	inhibits	disease	1.00
Tumor	inhibits	disease	1.00
Tumor	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
RAS	activates	gene	1.00
Carcinogenesis	involved_in	process	0.95
Lung Cancer	therapeutic_target	disease	0.95
cancer	associated_with	disease	0.95
Als	inhibits	disease	0.95
Cancer	regulates	disease	0.95
Ros	activates	process	0.95
pancreatic ductal adenocarcinoma	risk_factor_for	disease	0.95
Colorectal Cancer	therapeutic_target	disease	0.95
cancer	causes	disease	0.95
Carcinoma	therapeutic_target	disease	0.95
cancer therapy	therapeutic_target	process	0.93
CRAF	interacts_with	protein	0.92
oncogenic transformation	promotes	process	0.92
cancer cell proliferation	promotes	process	0.90
tumors	risk_factor_for	disease	0.90
covalent ligands	therapeutic_target	drug	0.90
Non-Small Cell Lung Cancer	associated_with	disease	0.90
MAPK	activates	pathway	0.90
Mitophagy	associated_with	process	0.90
Mitofission	associated_with	process	0.90
Autophagy	activates	pathway	0.90
PIK3CA	associated_with	gene	0.90
GENES	associated_with	gene	0.90
Tumor Microenvironment	therapeutic_target	pathway	0.90
EGFR	inhibits	gene	0.90
STAT3	upstream_of	gene	0.85
Als	associated_with	disease	0.85
PI3K/AKT/mTOR Pathway	activates	pathway	0.85
Ras-Targeting Therapies	targets	drug	0.85
Carcinoma	associated_with	disease	0.85
Pancreatic Cancer	inhibits	disease	0.85
AUTOPHAGY	activates	gene	0.80

Incoming (292)

Source	Relation	Type	Str
Merodantoin	activates	drug	0.90
KRAS inhibitors	inhibits	drug	0.90
PTEN	associated_with	gene	0.90
KRAS inhibitors	binds_to	drug	0.88
SOS1	activates	gene	0.85
GRB2	upstream_of	protein	0.80
PRMT1	interacts_with	entity	0.80
ARID1A	associated_with	gene	0.80
HRAS	associated_with	gene	0.70
FGFR3	associated_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
ERK	activates	gene	0.70
RAS	associated_with	protein	0.70
ERK	therapeutic_target	gene	0.70
APOPTOSIS	activates	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
APOPTOSIS	causes	gene	0.60
LDHA	activates	gene	0.60
PI3K	activates	gene	0.60
AND	associated_with	gene	0.60
MYC	associated_with	gene	0.60
PFKFB3	activates	gene	0.60
GLUT1	activates	gene	0.60
MAPK	activates	gene	0.60
HIF	activates	gene	0.60
CANCER	activates	gene	0.60
MYC	interacts_with	gene	0.60
AND	activates	gene	0.60
HIPPO	activates	gene	0.60
YAP	activates	gene	0.60
ONCOGENES	activates	gene	0.60
HSPG2	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
RAC1	activates	gene	0.60
ITGB6	causes	gene	0.60
HER3	causes	gene	0.60
AND	causes	gene	0.60
MEK	causes	gene	0.60
PRMT5	causes	gene	0.60
RAF	causes	gene	0.60
KEAP1	therapeutic_target	gene	0.60
CANCER	interacts_with	gene	0.60
CDKN2A	expressed_in	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
PTEN	therapeutic_target	gene	0.60
ROS	causes	gene	0.60
MITOPHAGY	causes	gene	0.60
BRAF	biomarker_for	gene	0.60
RAS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KRAS in their description or question text

No additional research found