gene

MLST8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MLST8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

315Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MLST8 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, expressed in. Associated with ALS, Als, Cancer. Connected to 129 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MLST8
Aliases	GBL, LST8, mLST8 [@maiese2020]
Chromosome	16p13.3 [@ehninger2014]
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	36 kDa
Amino Acids	326 aa
Exons	14
Pathways	MTOR, mtor, mTOR, mTOR signaling, mTOR pathway
UniProt ID	Q9BVC4
NCBI Gene ID	84923
Ensembl ID	ENSG00000167985
GeneCards	MLST8
Human Protein Atlas	MLST8
Associated Diseases	neurodegeneration
Known Drugs/Compounds	rapamycin
Interactions	Actin, AKT, AKT1, AKT1S1, AMBRA1, AMPK
KG Connections	315 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MLST8 — AlphaFold Q9BVC4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

MLST8 Gene

gene · 716 words

→

MLST8 Protein

protein · 1187 words

→

Pathway Diagram

flowchart TD
    MLST8["MLST8
mTOR Complex
Component"]
    MTOR["MTOR
Mechanistic Target
of Rapamycin"]
    RICTOR["RICTOR
mTORC2
Component"]
    
    mTORC1["mTORC1
Complex"]
    mTORC2["mTORC2
Complex"]
    
    AKT_pathway["AKT
Signaling"]
    PI3K_pathway["PI3K
Pathway"]
    Autophagy["Autophagy
Regulation"]
    
    FIP200["FIP200
Autophagy
Initiator"]
    AMBRA1["AMBRA1
Autophagy
Regulator"]
    PIK3C3["PIK3C3
VPS34
Kinase"]
    
    EGFR["EGFR
Growth Factor
Receptor"]
    STAT3["STAT3
Transcription
Factor"]
    
    ALS["ALS
Amyotrophic
Lateral Sclerosis"]
    MS["Multiple
Sclerosis"]
    Neurodegeneration["Neuronal
Death"]
    
    MLST8 -->|"stabilizes"| MTOR
    MLST8 -->|"essential for"| mTORC1
    MLST8 -->|"essential for"| mTORC2
    MTOR --> mTORC1
    MTOR --> mTORC2
    RICTOR --> mTORC2
    
    mTORC1 -->|"inhibits"| Autophagy
    mTORC2 -->|"activates"| AKT_pathway
    PI3K_pathway -->|"upstream"| AKT_pathway
    
    Autophagy -->|"involves"| FIP200
    Autophagy -->|"involves"| AMBRA1
    Autophagy -->|"involves"| PIK3C3
    
    EGFR -->|"activates"| PI3K_pathway
    AKT_pathway -->|"activates"| STAT3
    
    MLST8 -->|"dysregulated in"| ALS
    MLST8 -->|"dysregulated in"| MS
    ALS --> Neurodegeneration
    MS --> Neurodegeneration
    
    style MLST8 fill:#006494
    style Autophagy fill:#1b5e20
    style AKT_pathway fill:#1b5e20
    style PI3K_pathway fill:#1b5e20
    style mTORC1 fill:#4a1a6b
    style mTORC2 fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style RICTOR fill:#4a1a6b
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Neurodegeneration fill:#5d4400

Outgoing (175)

Target	Relation	Type	Str
Ms	activates	disease	0.65
Cancer	regulates	disease	0.65
ALS	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Wnt	regulates	pathway	0.60
MTOR	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
Oxidative Phosphorylation	interacts_with	pathway	0.60
Akt	regulates	pathway	0.60
Stem Cell	interacts_with	cell_type	0.60
Epithelial	interacts_with	cell_type	0.60
Dendritic Cell	interacts_with	cell_type	0.60
Egfr	interacts_with	protein	0.60
RICTOR	interacts_with	gene	0.60
Mtor	regulates	pathway	0.60
AUTOPHAGY	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
Angiogenesis	regulates	pathway	0.60
Akt	inhibits	pathway	0.60
NRBF2	interacts_with	gene	0.60
CYP1A1	interacts_with	gene	0.60
GCN2	interacts_with	gene	0.60
AKT1S1	interacts_with	gene	0.60
ATP	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
MTORC1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
Rb	interacts_with	protein	0.60
Autophagy	interacts_with	pathway	0.60
Mapk	interacts_with	pathway	0.60
Pi3K	interacts_with	pathway	0.60

Incoming (140)

Source	Relation	Type	Str
AND	regulates	gene	0.60
CYP1A1	activates	gene	0.60
DNA	activates	gene	0.60
GCN2	activates	gene	0.60
IFN	activates	gene	0.60
MAPK	activates	gene	0.60
rapamycin	targets	drug	0.60
CANCER	regulates	gene	0.60
MTORC1	regulates	gene	0.60
GABA	interacts_with	gene	0.60
DDIT3	phosphorylates	entity	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60
EIF2A	phosphorylates	entity	0.60
EIF2AK3	phosphorylates	entity	0.60
ERN1	phosphorylates	entity	0.60
FIP200	phosphorylates	entity	0.60
GABARAP	phosphorylates	entity	0.60
GRB2	phosphorylates	entity	0.60
HMGB1	phosphorylates	entity	0.60
HSP70	phosphorylates	entity	0.60
HSPA5	phosphorylates	entity	0.60
IFNG	phosphorylates	entity	0.60
JNK	phosphorylates	entity	0.60
LRRK2	phosphorylates	entity	0.60
MAP1LC3A	phosphorylates	entity	0.60
MAPK14	phosphorylates	entity	0.60
MAVS	phosphorylates	entity	0.60
MLKL	phosphorylates	entity	0.60
APC	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
HSPA5	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
MAVS	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
CANCER	phosphorylates	entity	0.60
OPTN	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MLST8 in their description or question text

No additional research found