gene

CD44

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD44: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

749Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CD44 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, inhibits. Associated with Aging, Als, Alzheimer. Connected to 358 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD44
Full Name	Cell Surface Glycoprotein
Aliases	Page for CD44
Chromosome	11p13
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	95 kDa
Amino Acids	341 aa
Exons	19
Pathways	NF-κB, TGF-β
NCBI Gene ID	2115452
Ensembl ID	ENSG00000026508
GeneCards	CD44
Human Protein Atlas	CD44
Associated Diseases	Aging, Als, Alzheimer, Cardiac, dementia
Interactions	ADAM10, AKT, ALS, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
KG Connections	749 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CD44 - Cell Surface Glycoprotein

gene · 1313 words

→

CD44 Protein

protein · 1350 words

→

Pathway Diagram

graph TD
    CD44["CD44"]
    CD44 -->|"inhibits"| Cancer["Cancer"]
    CD44 -->|"inhibits"| Tumor["Tumor"]
    CD44 -->|"target for"| Fibrosis["Fibrosis"]
    CD44 -->|"target for"| Hepatitis["Hepatitis"]
    CD44 -->|"target for"| Carcinoma["Carcinoma"]
    CD44 -->|"target for"| Als["Als"]
    CD44 -->|"target for"| Inflammation["Inflammation"]
    FGF20["FGF20"] -->|"target for"| CD44
    BRG1["BRG1"] -->|"target for"| CD44
    NRCAM["NRCAM"] -->|"target for"| CD44
    NOTCH2["NOTCH2"] -->|"target for"| CD44
    EP300["EP300"] -->|"target for"| CD44
    CTNNB1["CTNNB1"] -->|"target for"| CD44
    NEUROD1["NEUROD1"] -->|"target for"| CD44
    MYC["MYC"] -->|"target for"| CD44

Outgoing (576)

Target	Relation	Type	Str
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
Tumor	therapeutic_target	disease	0.95
ERK	activates	protein	0.88
Als	therapeutic_target	disease	0.85
MICROGLIA	upregulates	cell_type	0.85
Tumor	inhibits	disease	0.85
microglia	upregulates	cell_type	0.80
microglia migration	promotes	process	0.80
Lung Cancer	therapeutic_target	disease	0.75
Cancer	inhibits	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Cancer	activates	disease	0.75
Fibrosis	therapeutic_target	disease	0.75
Als	associated_with	disease	0.75
Als	activates	disease	0.75
Carcinoma	activates	disease	0.75
Pancreatic Cancer	therapeutic_target	disease	0.75
Mapk	inhibits	pathway	0.70
Notch	therapeutic_target	pathway	0.70
HIF	therapeutic_target	gene	0.70
CANCER	inhibits	gene	0.70
ABCB1	therapeutic_target	gene	0.70
SOX2	inhibits	gene	0.70
lipid metabolism	participates_in	pathway	0.70
Glycolysis	therapeutic_target	pathway	0.70
CANCER	activates	gene	0.70
MYC	targets	gene	0.70
Rheumatoid Arthritis	therapeutic_target	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Neuroinflammation	interacts_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Stroke	interacts_with	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
ALS	interacts_with	disease	0.65
Stroke	expressed_in	disease	0.65
Cancer	regulates	disease	0.65
Infection	activates	disease	0.65
Senescence	activates	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Huntington	associated_with	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Fibrosis	activates	disease	0.65

Incoming (173)

Source	Relation	Type	Str
SPP1	binds_to	protein	0.93
AKT	regulates	protein	0.85
MYC	enhances	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
ASTROCYTES	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
COMPLEMENT	contributes_to	gene	0.60
FN1	associated_with	gene	0.60
JAK	activates	gene	0.60
HUNTINGTON'S DISEASE	associated_with	gene	0.60
ASTROCYTE	interacts_with	gene	0.60
PARKINSON	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
COMPLEMENT	interacts_with	gene	0.60
COMPLEMENT	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
DACH1	inhibits	gene	0.60
RNA	inhibits	gene	0.60
STROKE	interacts_with	gene	0.60
RNA	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
ASTROCYTES	interacts_with	gene	0.60
RUNX2	associated_with	gene	0.60
CCL2	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
HUNTINGTON	associated_with	gene	0.60
NEUROINFLAMMATION	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
GENES	regulates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
AGING	associated_with	gene	0.60
CD24	inhibits	gene	0.60
RNA	therapeutic_target	gene	0.60
STROKE	associated_with	gene	0.60
CCND1	targets	gene	0.60
ALDH1A1	targets	gene	0.60
CLDN1	therapeutic_target	gene	0.60
AXIN1	therapeutic_target	gene	0.60
ANXA2	activates	gene	0.60
ICAM1	activates	gene	0.60
CDKN2A	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
TNC	inhibits	gene	0.60
NTRK2	inhibits	gene	0.60
PAK1	inhibits	gene	0.60
WNT7A	inhibits	gene	0.60
LZTS1	inhibits	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 2: GPNMB-CD44 Axis as Anti-inflammatory Pathway	0.772	neurodegeneration	View
CD44-Mediated Src/PI3K/Akt Signaling Cascade	0.470	neuroinflammation	What molecular mechanisms mediate SPP1-i

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
The temporal and stimuli-specific effects of LPS and IFNγ on microglial activati [PMID:41695273]	Heiss CN, Naylor AS, Pesämaa I, Meshi A,	Front Aging Neurosci	2026	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD44 in their description or question text

No additional research found