gene

CAPN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAPN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

64Connections

0Hypotheses

0Analyses

48Outgoing

16Incoming

0Experiments

0Debates

Summary

CAPN1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, implicated in. Associated with Als, Inflammation. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CAPN1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	most tissues with highest levels in[@murphy1986]:
Molecular Weight	80 kDa
Pathways	MAPK, mapk
Ensembl ID	ENSG00000021645
GeneCards	CAPN1
Human Protein Atlas	CAPN1
Catalytic subunit (CAPN1, 80 kDa)	Contains the protease core with conserved cysteine protease domain
Regulatory subunit (CAPNS1, 28 kDa)	Required for enzyme stability, proper folding, and calcium sensitivity
Amyloid-beta effects	Aβ peptides trigger calcium dysregulation, leading to calpain overactivation
[Tau](/proteins/tau) cleavage	Calpain cleaves tau protein, generating toxic fragments that promote tau aggregation
Caspase activation	Calpain activates caspase-3, linking to apoptotic cell death
Synaptic damage	Overactivated calpain degrades synaptic proteins including PSD-95 and NMDA receptors
Biomarkers	Calpain-cleaved spectrin breakdown products (SBDPs) serve as biomarkers of neuronal injury
Associated Diseases	ALS, Alzheimer's disease, frontotemporal dementia
Interactions	AKT, AKT1, AND, BACE1, CDK5, DEPRESSION
KG Connections	64 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CAPN1 Gene

gene · 1350 words

→

CAPN1 Protein

protein · 740 words

→

Pathway Diagram

graph TD
    CAPN1["CAPN1"]
    Inflammation{"Inflammation"}
    CAPN1 -->|"therapeutic target"| Inflammation
    Als{"Als"}
    CAPN1 -->|"therapeutic target"| Als
    TTR["TTR"]
    CAPN1 -->|"therapeutic target"| TTR
    LGALS3["LGALS3"]
    CAPN1 -->|"therapeutic target"| LGALS3
    CTSD["CTSD"]
    CAPN1 -->|"therapeutic target"| CTSD
    GRB2["GRB2"]
    CAPN1 -->|"therapeutic target"| GRB2
    TLR4["TLR4"]
    CAPN1 -->|"therapeutic target"| TLR4
    NFE2L2["NFE2L2"]
    CAPN1 -->|"therapeutic target"| NFE2L2
    RPS6KA1["RPS6KA1"]
    CAPN1 -->|"therapeutic target"| RPS6KA1
    HIF1A["HIF1A"]
    CAPN1 -->|"therapeutic target"| HIF1A
    GRIN1["GRIN1"]
    CAPN1 -->|"therapeutic target"| GRIN1
    ADAM10["ADAM10"]
    CAPN1 -->|"therapeutic target"| ADAM10
    GENES["GENES"]
    GENES -->|"therapeutic target"| CAPN1
    style CAPN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (48)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:CAPN1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ALS	activates	disease	0.65
Depression	activates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
CTSD	therapeutic_target	gene	0.60
GRB2	therapeutic_target	gene	0.60
TLR4	therapeutic_target	gene	0.60
NFE2L2	therapeutic_target	gene	0.60
RPS6KA1	therapeutic_target	gene	0.60
HIF1A	therapeutic_target	gene	0.60
GRIN1	therapeutic_target	gene	0.60
ADAM10	therapeutic_target	gene	0.60
BACE1	activates	gene	0.60
AKT1	activates	gene	0.60
LITAF	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
POLG	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
TTR	therapeutic_target	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
LGALS3	therapeutic_target	gene	0.60
oxidative stress response	participates_in	pathway	0.60
Alzheimer's disease	associated_with	disease	0.60
frontotemporal dementia	associated_with	disease	0.60
DEPRESSION	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	activates	gene	0.60
ALS	associated_with	disease	0.60
Neuron	activates	cell_type	0.60
AKT	activates	gene	0.60
AND	activates	gene	0.60
GSK-3Β	activates	gene	0.60
CDK5	activates	gene	0.60
Gsk-3	activates	protein	0.60
Akt	activates	pathway	0.60
Long-Term Potentiation	activates	pathway	0.60
Dentate Gyrus	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
PSEN2	activates	gene	0.50
MAPT	activates	gene	0.50
Hippocampus	activates	entity	0.50

Incoming (16)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CAPN1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
ALS4	associated_with	gene	0.60
APP	associated_with	gene	0.60
AKT	activates	gene	0.60
MAPT	activates	gene	0.60
CDK5	activates	gene	0.60
AKT1	activates	gene	0.60
PSEN2	activates	gene	0.60
BACE1	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
GENES	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
DEPRESSION	activates	gene	0.60
AND	activates	gene	0.60
Neurodegeneration	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CAPN1 in their description or question text

No additional research found