gene 541 words KG: GRB2
Contents

GRB2 — Growth Factor Receptor Bound Protein 2

🧬 Gene Info
Gene SymbolGRB2
Full NameGrowth Factor Receptor Bound Protein 2
Chromosome17q25.1.
Protein TypeAdaptor Protein
Functionis an adaptor protein encoded by the GRB2 gene on chromosome 17q25.1
Primary ExpressionUbiquitous (neurons, glia, all tissues)
PathwaysMAPK, PI3K
UniProt IDP62993
NCBI Gene ID2885
Ensembl IDENSG00000177885
OMIM108355
GeneCardsGRB2
Human Protein AtlasGRB2
Associated DiseasesParkinson
Known Drugs/Compoundsrapamycin
InteractionsActin, AKT, AKT1, AKT1S1, AMBRA1, AMPK
KG Connections384 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.38
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.68

Related Analyses (9)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: interacts_with
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: interacts_with
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: interacts_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: therapeutic_target
AKT1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

OPTN interacts_with GRB2
CASP3 interacts_with GRB2
AKT1 interacts_with GRB2
CALCOCO2 interacts_with GRB2
CGAS interacts_with GRB2
CFTR interacts_with GRB2
SQSTM1 interacts_with GRB2
RPS6KB1 interacts_with GRB2
GRB2 interacts_with RHEB
GRB2 interacts_with STING1

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