concept

CYP1A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CYP1A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

338Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

CYP1A1 is a concept in neurodegeneration research. Key relationships include: interacts with, associated with, expressed in. Associated with ALS, Cancer, Carcinoma. Connected to 110 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	CYP1A1
Key Genes/Proteins	AADC, Actin, AHR, Akt, AKT1, AKT1S1
Related Diseases	Als, ALS
Related Pathways	Apoptosis

Pathway Diagram

graph TD
    CYP1A1["CYP1A1"]
    CYP1A1 -->|"expressed in"| Carcinoma["Carcinoma"]
    CYP1A1 -->|"interacts"| ALS["ALS"]
    CYP1A1 -->|"interacts"| Fibrosis["Fibrosis"]
    CYP1A1 -->|"interacts"| Cancer["Cancer"]
    CYP1A1 -->|"interacts"| P38["P38"]
    CYP1A1 -->|"interacts"| PI3K["PI3K"]
    CYP1A1 -->|"interacts"| MLST8["MLST8"]
    CYP1A1 -->|"interacts"| AUTOPHAGY["AUTOPHAGY"]
    CYP1A1 -->|"interacts"| AKT1["AKT1"]
    CYP1A1 -->|"interacts"| IFN["IFN"]
    ROS["ROS"] -->|"interacts"| CYP1A1
    RICTOR["RICTOR"] -->|"interacts"| CYP1A1
    MTOR["MTOR"] -->|"interacts"| CYP1A1
    MAP1LC3A["MAP1LC3A"] -->|"interacts"| CYP1A1
    LC3["LC3"] -->|"interacts"| CYP1A1
    DNA["DNA"] -->|"interacts"| CYP1A1
    RHEB["RHEB"] -->|"interacts"| CYP1A1
    LYSOSOME["LYSOSOME"] -->|"interacts"| CYP1A1
    MAVS["MAVS"] -->|"interacts"| CYP1A1
    RB1["RB1"] -->|"interacts"| CYP1A1

Outgoing (188)

Target	Relation	Type	Str
Carcinoma	expressed_in	disease	0.80
Fibrosis	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Cardiovascular	inhibits	disease	0.65
Cardiomyopathy	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
MTORC1	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
CCND1	associated_with	gene	0.60
Oxidative Stress	inhibits	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
NOX4	associated_with	gene	0.60
MMP2	associated_with	gene	0.60
DIABETES MELLITUS	inhibits	gene	0.60
ROS	regulates	gene	0.60
MAO	regulates	gene	0.60
AND	activates	gene	0.60
AADC	regulates	gene	0.60
ROS	inhibits	gene	0.60
SLC2A1	associated_with	gene	0.60
Cardiomyocyte	inhibits	cell_type	0.60
Caspase	inhibits	protein	0.60
Ngf	inhibits	protein	0.60
NLR	interacts_with	gene	0.60
Caspase	interacts_with	protein	0.60
Rb	interacts_with	protein	0.60
Stat3	interacts_with	protein	0.60
Actin	interacts_with	protein	0.60
Akt	interacts_with	protein	0.60
MMP2	interacts_with	gene	0.60
NOX4	interacts_with	gene	0.60
RAGE	interacts_with	gene	0.60
SLC2A1	interacts_with	gene	0.60
CYP3A4	activates	gene	0.60
HSPA1A	activates	gene	0.60
GCN2	interacts_with	gene	0.60
ATG16L1	interacts_with	gene	0.60
RPS6KB1	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
RHEB	interacts_with	gene	0.60

Incoming (150)

Source	Relation	Type	Str
SLC2A1	associated_with	gene	0.60
NLR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
MAPK	interacts_with	gene	0.60
NRBF2	interacts_with	gene	0.60
GABA	interacts_with	gene	0.60
AKT1S1	interacts_with	gene	0.60
MMP2	associated_with	gene	0.60
ERK	inhibits	gene	0.60
ROS	inhibits	gene	0.60
NOX4	associated_with	gene	0.60
APOPTOSIS	inhibits	gene	0.60
DDIT3	interacts_with	gene	0.60
CFTR	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
CASP3	interacts_with	gene	0.60
CGAS	interacts_with	gene	0.60
rapamycin	targets	drug	0.60
IFN	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
IFNG	interacts_with	gene	0.60
TFEB	interacts_with	gene	0.60
GRB2	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
AADC	regulates	gene	0.60
MAO	regulates	gene	0.60
ROS	regulates	gene	0.60
MAO-B	regulates	gene	0.60
CYP1A2	activates	gene	0.60
RAS	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
JNK	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CYP1A1 in their description or question text

No additional research found