AND

Understanding Entity Pages

This page aggregates everything SciDEX knows about AND: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    subgraph Interactions["Interactions"]
        AND["AND"] -->|"participates in"| oxidative_stress_response["oxidative stress response"]
        AND["AND"] -->|"participates in"| apoptosis_pathway["apoptosis pathway"]
        AND["AND"] -->|"interacts with"| Alzheimer_s_disease["Alzheimer's disease"]
        AND["AND"] -->|"participates in"| ubiquitin_proteasome["ubiquitin-proteasome"]
        TP53["TP53"] -->|"interacts with"| AND["AND"]
        APOPTOSIS_2["APOPTOSIS"] -->|"interacts with"| AND["AND"]
    end
    subgraph Therapeutic["Therapeutic"]
        AND["AND"] -->|"expressed in"| endothelial_cells["endothelial cells"]
    end
    subgraph Pathology["Pathology"]
        AND["AND"] -->|"associated with"| Alzheimer_s_disease_1["Alzheimer's disease"]
        AND["AND"] -->|"associated with"| neurodegeneration["neurodegeneration"]
        AND["AND"] -->|"associated with"| PS1["PS1"]
        AND["AND"] -->|"associated with"| Atherosclerosis["Atherosclerosis"]
        MYC["MYC"] -->|"associated with"| AND["AND"]
        JUN["JUN"] -->|"associated with"| AND["AND"]
        APOPTOSIS["APOPTOSIS"] -->|"associated with"| AND["AND"]
    end
    subgraph Signaling["Signaling"]
        CYTOKINES["CYTOKINES"] -->|"activates"| AND["AND"]
    end
    style AND fill:#90a4ae,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style oxidative_stress_response fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style apoptosis_pathway fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style endothelial_cells fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_s_disease fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Alzheimer_s_disease_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style neurodegeneration fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PS1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style ubiquitin_proteasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Atherosclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TP53 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MYC fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style JUN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style CYTOKINES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOPTOSIS_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

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