protein

YWHAG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YWHAG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

1Hypotheses

1Analyses

21Outgoing

23Incoming

0Experiments

1Debates

Summary

YWHAG is a protein involved in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als. Connected to 23 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	YWHAG
Full Name	Tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein Gamma
Chromosome	7q11.23
Function	YWHAG encodes the 14-3-3 gamma protein, which performs several critical functions in neurons
Molecular Weight	28 kDa
Pathways	Akt, Apoptosis, Autophagy, Mitophagy, Mtor
UniProt ID	YWHAG
NCBI Gene ID	7532
Ensembl ID	ENSG00000100911
OMIM	605066
GeneCards	YWHAG
Human Protein Atlas	YWHAG
Associated Diseases	neurodegeneration
Interactions	ACETYL-COA, AKT, AND, APOPTOSIS, AUTOPHAGY, BIP
SciDEX Hypotheses	YWHAG-Mediated TFEB Subcellular Targeting
KG Connections	44 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

YWHAG Gene

gene · 552 words

→

YWHAG Protein

protein · 912 words

→

Pathway Diagram

graph TD
    YWHAG["YWHAG"]
    Als{"Als"}
    YWHAG -->|"activates"| Als
    RICTOR["RICTOR"]
    YWHAG -->|"activates"| RICTOR
    AKT["AKT"]
    YWHAG -->|"activates"| AKT
    ENDOG["ENDOG"]
    YWHAG -->|"activates"| ENDOG
    MTORC1["MTORC1"]
    YWHAG -->|"activates"| MTORC1
    BIP["BIP"]
    YWHAG -->|"activates"| BIP
    IRE1A["IRE1A"]
    YWHAG -->|"activates"| IRE1A
    APOPTOSIS["APOPTOSIS"]
    YWHAG -->|"activates"| APOPTOSIS
    AUTOPHAGY["AUTOPHAGY"]
    YWHAG -->|"activates"| AUTOPHAGY
    TSC2["TSC2"]
    YWHAG -->|"activates"| TSC2
    EIF2AK3["EIF2AK3"]
    YWHAG -->|"activates"| EIF2AK3
    GSK3B["GSK3B"]
    YWHAG -->|"activates"| GSK3B
    PIK3C3["PIK3C3"]
    PIK3C3 -->|"activates"| YWHAG
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| YWHAG
    style YWHAG fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (21)

Target	Relation	Type	Str
Als	activates	disease	0.65
IRE1A	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
Autophagy	activates	pathway	0.60
Akt	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Mtor	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
MTORC1	activates	gene	0.60
RICTOR	activates	gene	0.60
AKT	activates	gene	0.60
ENDOG	activates	gene	0.60
BIP	activates	gene	0.60
TSC2	activates	gene	0.60
EIF2AK3	activates	gene	0.60
GSK3B	activates	gene	0.60
ERN1	activates	gene	0.60
HSPA5	activates	gene	0.60
neurodegeneration	associated_with	disease	0.50

Incoming (23)

Source	Relation	Type	Str
h-3d2aa5a6	targets	hypothesis	0.90
APOPTOSIS	activates	gene	0.60
DNA	activates	gene	0.60
ACETYL-COA	activates	gene	0.60
IRE1A	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
PIK3C3	activates	gene	0.60
ERN1	activates	gene	0.60
PERK	activates	gene	0.60
ENDOG	activates	gene	0.60
AKT	activates	gene	0.60
HSPA5	activates	gene	0.60
TSC2	activates	gene	0.60
GSK3B	activates	gene	0.60
EIF2AK3	activates	gene	0.60
RICTOR	activates	gene	0.60
AND	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
TFEB	regulated_by	gene	0.50
ATP6V1A	co_associated_with	gene	0.40
ULK1	co_associated_with	gene	0.40
TFE3	co_associated_with	gene	0.40
LAMTOR1	co_associated_with	gene	0.40

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
YWHAG-Mediated TFEB Subcellular Targeting	0.549	neurodegeneration	Does TFEB dysfunction cause neurodegener

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does TFEB dysfunction cause neurodegeneration or represent a compensatory respon

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.697

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Integrated Bioinformatics Analysis of Screen Mitochondrial Autophagy-Related Cor [PMID:41731906]	Gao Z, Wang Y, Ren Y, Lyu J	J Neurochem	2026	0
Charting the research frontier for viral infections, immunomodulation, and demen [PMID:41561087]	Lee CK, Woodward M, Hohenberg MI, Tang J	Front Cell Infect Microbiol	2025	0

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted TFEB's role in mitochondrial-lysosomal coupling but could

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Related Research

Hypotheses and analyses mentioning YWHAG in their description or question text

No additional research found