gene

EGFR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3016Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

EGFR is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, interacts with. Associated with AD, ADH, ALS. Connected to 1370 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	EGFR
Chromosome	7
Protein Family	ErbB/EGFR tyrosine kinase family
Protein Type	Receptor
Function	EGFR (Epidermal Growth Factor Receptor) is a receptor tyrosine kinase that binds EGF, TGF-α, and other ligands.
Primary Expression	neural stem cells, astrocytes, and neurons, where it regulates neurogenesis, gliogenesis, synaptic plasti
Molecular Weight	134.3 kDa
Pathways	Akt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle
UniProt ID	[P00533](https://www.uniprot.org/uniprot/P00533)
GeneCards	EGFR
Human Protein Atlas	EGFR
Associated Diseases	AD, ADH, Aging, Als, Alzheimer
Known Drugs/Compounds	AFB1, amivantamab, Amivantamab, COENZYME Q10, EGFR-TKI, FLUOXETINE
Interactions	ABCA1, ABCB1, ACE, ACTB, ACTG1, Actin
KG Connections	2678 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    EGFR["EGFR"] -->|"regulates"| cell_proliferation["cell proliferation"]
    EGFR["EGFR"] -->|"regulates"| cell_differentiation["cell differentiation"]
    EGFR["EGFR"] -->|"regulates"| apoptosis["apoptosis"]
    EGFR["EGFR"] -->|"causes"| tumorigenesis["tumorigenesis"]
    EGFR["EGFR"] -->|"activates"| SRC["SRC"]
    EGFR["EGFR"] -->|"activates"| AKT["AKT"]
    tyrosine_kinase_inhibitors["tyrosine kinase inhibitors"] -.->|"inhibits"| EGFR["EGFR"]
    monoclonal_antibodies["monoclonal antibodies"] -.->|"inhibits"| EGFR["EGFR"]
    GGA2["GGA2"] -->|"binds"| EGFR["EGFR"]
    PIEZO1["PIEZO1"] -->|"activates"| EGFR["EGFR"]
    style EGFR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1905)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:EGFR	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:EGFR	data_in	dataset_row	0.00
Tumor	activates	disease	1.00
Apoptosis	activates	pathway	1.00
Als	activates	disease	1.00
Cancer	activates	disease	1.00
AKT	therapeutic_target	gene	1.00
Als	inhibits	disease	1.00
Als	associated_with	disease	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Carcinoma	activates	disease	1.00
Tumor	expressed_in	disease	1.00
Lung Cancer	therapeutic_target	disease	1.00
CANCER	activates	gene	1.00
AKT	activates	protein	1.00
Egfr Signaling	activates	pathway	1.00
Colorectal Cancer	therapeutic_target	disease	1.00
SRC	activates	protein	1.00
Apoptosis	therapeutic_target	pathway	1.00
DNA	therapeutic_target	gene	1.00
Inflammation	therapeutic_target	disease	1.00
CANCER	therapeutic_target	gene	1.00
Wnt	activates	pathway	1.00
Tumor	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
monoclonal antibodies	targets	drug	1.00
Lung Cancer	inhibits	disease	1.00
Lung Cancer	associated_with	disease	1.00
Carcinoma	therapeutic_target	disease	1.00
Cancer	inhibits	disease	1.00
CANCER	inhibits	gene	1.00
Cancer	therapeutic_target	disease	1.00
GENES	therapeutic_target	gene	1.00
Pi3K/Akt	therapeutic_target	pathway	1.00
Breast Cancer	therapeutic_target	disease	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Mapk	therapeutic_target	pathway	1.00
tyrosine kinase inhibitors	targets	drug	1.00
Tumor	associated_with	disease	1.00
Glioblastoma	activates	disease	1.00
Lung Cancer	activates	disease	1.00
Tumor	inhibits	disease	1.00
Cancer	associated_with	disease	1.00
EGF	binds	protein	1.00
Mapk	activates	pathway	1.00
GENES	activates	gene	1.00
Mtor	therapeutic_target	pathway	1.00
Mtor	activates	pathway	1.00
MTOR	activates	gene	1.00
Pi3K/Akt	activates	pathway	1.00

Incoming (1111)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:EGFR	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:EGFR	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
CANCER	associated_with	gene	1.00
PI3K	activates	gene	1.00
APOPTOSIS	activates	gene	1.00
PI3K	therapeutic_target	gene	1.00
CANCER	therapeutic_target	gene	1.00
CANCER	inhibits	gene	1.00
ERK	activates	gene	1.00
CANCER	activates	gene	1.00
EGFR MUTATIONS	inhibits	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
TP53	associated_with	gene	1.00
amphiregulin	binds_to	protein	0.95
panitumumab	binds_to	drug	0.95
amivantamab	therapeutic_target	drug	0.90
osimertinib	therapeutic_target	drug	0.90
lazertinib	therapeutic_target	drug	0.90
dural Tregs	increases	cell_type	0.90
monoclonal antibodies	inhibits	drug	0.90
tyrosine kinase inhibitors	inhibits	drug	0.90
AFB1	activates	drug	0.90
Thiabendazole	binds	drug	0.90
TP53	therapeutic_target	gene	0.90
AKT1	therapeutic_target	gene	0.90
KRAS	inhibits	gene	0.90
OXIDATIVE STRESS	therapeutic_target	gene	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.88
Thiabendazole	binds_to	drug	0.85
GNT-V	modulates	gene	0.85
FUT8	modulates	gene	0.85
GNT-III	modulates	gene	0.85
Nomilin	binds	compound	0.85
nomilin	binds_to	drug	0.84
EGF	activates	protein	0.82
AKT	associated_with	gene	0.82
GGA2	binds	protein	0.80
PRKCD	associated_with	gene	0.80
APOPTOSIS	inhibits	gene	0.80
EGF	interacts_with	gene	0.80
VEGF	therapeutic_target	gene	0.80
TNF	therapeutic_target	gene	0.80
STAT3	therapeutic_target	gene	0.80
INFLAMMATION	therapeutic_target	gene	0.80
MAPK3	therapeutic_target	gene	0.80
PI3K	inhibits	gene	0.80
AKT1	interacts_with	gene	0.80
PI3K	associated_with	gene	0.80
CANCER	interacts_with	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

EGFR

Understanding Entity Pages

Summary

Wiki Pages (10)

EGFR Protein

EGFR Signaling in Parkinson's Disease

PD EGFR and Receptor Tyrosine Kinase Therapeutic Companies

EGFR — Epidermal Growth Factor Receptor

PD EGFR Signaling Therapy Companies

Parkinson's Disease EGFR Signaling Therapy Companies