concept

GCN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GCN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

184Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	GCN2
Key Genes/Proteins	AKT1, AKT1S1, AMBRA1, AMPK, AMPKα2, AND
Related Diseases	ALS, amino acid insufficiency
Related Pathways	Apoptosis, apoptosis pathway

Pathway Diagram

graph TD
    GCN2["GCN2"]
    GCN2 -->|"involved_in"| Integrated_Stress_Response["Integrated Stress Response"]
    GCN2 -->|"interacts"| Cancer["Cancer"]
    GCN2 -->|"interacts"| ALS["ALS"]
    GCN2 -->|"interacts"| Fibrosis["Fibrosis"]
    GCN2 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    Identified_Compounds["Identified Compounds"] -->|"targets"| GCN2
    ISR_Potentiators["ISR Potentiators"] -->|"targets"| GCN2
    LC3["LC3"] -->|"interacts"| GCN2
    CALCOCO2["CALCOCO2"] -->|"interacts"| GCN2
    ERN1["ERN1"] -->|"interacts"| GCN2
    LRRK2["LRRK2"] -->|"interacts"| GCN2
    WNT["WNT"] -->|"interacts"| GCN2
    RB1["RB1"] -->|"interacts"| GCN2

Outgoing (118)

Target	Relation	Type	Str
Integrated Stress Response	involved_in	pathway	0.90
AMPKα2	associated_with	gene	0.90
PRKAA2	phosphorylates	gene	0.90
Cancer	interacts_with	disease	0.65
Fibrosis	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Tumor	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
APOPTOSIS	activates	gene	0.60
CANCER	regulates	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
HSP90	activates	gene	0.60
ferroptosis	participates_in	pathway	0.60
GPX4	interacts_with	gene	0.60
HSP90	interacts_with	gene	0.60
GSH	regulates	gene	0.60
HSP90	regulates	gene	0.60
HSP90	associated_with	gene	0.60
HSP90	inhibits	gene	0.60
MAVS	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60
RIPK1	interacts_with	gene	0.60
EIF2AK3	interacts_with	gene	0.60
Apoptosis	activates	pathway	0.60
AND	activates	gene	0.60
ATF4	activates	gene	0.60
IFNG	activates	gene	0.60
JNK	activates	gene	0.60
LC3	activates	gene	0.60
LRRK2	activates	gene	0.60
MAP1LC3A	activates	gene	0.60
MAPK	activates	gene	0.60
MAPK14	activates	gene	0.60
MAVS	activates	gene	0.60
MLKL	activates	gene	0.60
MLST8	activates	gene	0.60
MTOR	activates	gene	0.60
MTORC1	activates	gene	0.60
NBR1	activates	gene	0.60
NLR	activates	gene	0.60
NRBF2	activates	gene	0.60
OPTN	activates	gene	0.60
PI3K	activates	gene	0.60
PIK3C3	activates	gene	0.60
PPARG	activates	gene	0.60
RB1	activates	gene	0.60

Incoming (66)

Source	Relation	Type	Str
Identified Compounds	targets	compound	0.90
ISR Potentiators	targets	compound	0.88
amino acid insufficiency	activates	phenotype	0.85
P53	activates	gene	0.60
DNA	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
AND	inhibits	gene	0.60
CYP1A1	activates	gene	0.60
DDIT3	activates	gene	0.60
DEPTOR	activates	gene	0.60
EGF	activates	gene	0.60
EGFR	activates	gene	0.60
EIF2A	activates	gene	0.60
EIF2AK3	activates	gene	0.60
ERN1	activates	gene	0.60
FIP200	activates	gene	0.60
GABA	activates	gene	0.60
GABARAP	activates	gene	0.60
rapamycin	targets	drug	0.60
ATF4	interacts_with	gene	0.60
ATF4	associated_with	gene	0.60
ATF4	inhibits	gene	0.60
CYP1A1	interacts_with	gene	0.60
P38	interacts_with	gene	0.60
HSP70	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
ERN1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
WNT	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
OPTINEURIN	interacts_with	gene	0.60
FIP200	interacts_with	gene	0.60
AKT1	interacts_with	gene	0.60
ATF6	interacts_with	gene	0.60
CDH1	interacts_with	gene	0.60
EGF	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
NLR	interacts_with	gene	0.60
IFN	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
DEPTOR	interacts_with	gene	0.60
TFE3	interacts_with	gene	0.60
RPTOR	interacts_with	gene	0.60
RICTOR	interacts_with	gene	0.60
HMGB1	interacts_with	gene	0.60
MLST8	interacts_with	gene	0.60
APC	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
LYSOSOME	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GCN2 in their description or question text

No additional research found