gene

IL1B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1828Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

IL1B is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, interacts with. Associated with AD, ALS, AMI. Connected to 694 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL1B
Full Name	Interleukin-1 Beta
Chromosome	2q14.1
Protein Type	Ligand
Target Class	Ligand
Function	IL-1 receptor antagonist or neutralizing monoclonal antibody
Mechanism of Action	IL-1 receptor antagonist or neutralizing monoclonal antibody
Subcellular Localization	</th><td>Secreted, cytosol</td></tr>
Druggability	Medium (0.49)
Clinical Stage	Approved
Molecular Weight	31 kDa
Amino Acids	269 aa
Exons	7
Pathways	Akt, Apoptosis, Epigenetic, Mapk, Oxidative Stress
UniProt ID	O43645
NCBI Gene ID	3553
Ensembl ID	ENSG00000125538
OMIM	164520
GeneCards	IL1B
Human Protein Atlas	IL1B
Associated Diseases	AD, Aging, Als, Alzheimer
Known Drugs/Compounds	ANTHOCYANINS, berberine, Berberine, Guhan Yangsheng Jing, rapamycin, resveratrol
Interactions	A2M, ACACA, ACHE, ACTB, Actin, ADAM17
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Peripheral-to-Central Inflammation Circuit Breaker
KG Connections	1828 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — IL1B Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1I1B — X-ray / Cryo-EM

🔮 AI Predicted Structure

O43645 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IL1B — Interleukin-1 Beta

protein · 1526 words

→

IL1B Gene - Interleukin 1 Beta

gene · 754 words

→

Pathway Diagram

flowchart TD
    IL1B(["IL1B"])
    Inflammation["Inflammation"]
    inflammatory_diseases["inflammatory diseases"]
    Neuroinflammation("Neuroinflammation")
    h_e7e1f943["h-e7e1f943"]
    INFLAMMASOME_COMPLEX(["INFLAMMASOME COMPLEX"])
    NLRP3_Inflammasome["NLRP3 Inflammasome"]
    Inflammasome["Inflammasome"]
    Autophagy["Autophagy"]
    TNF(["TNF"])
    Als["Als"]
    Myeloid_Cell_Immune_Response("Myeloid Cell Immune Response")
    Infection["Infection"]
    CASP1["CASP1"]

    IL1B -->|"activates"| Inflammation
    IL1B -->|"causes"| inflammatory_diseases
    IL1B -->|"mediates"| Neuroinflammation
    h_e7e1f943 -->|"therapeutic target"| IL1B
    INFLAMMASOME_COMPLEX -->|"associated with"| IL1B
    h_e7e1f943 -->|"targets gene"| IL1B
    NLRP3_Inflammasome -->|"upregulates"| IL1B
    Inflammasome -->|"associated with"| IL1B
    IL1B -->|"activates"| Autophagy
    TNF -->|"activates"| IL1B
    IL1B -->|"activates"| Als
    IL1B -->|"mediates"| Myeloid_Cell_Immune_Response
    IL1B -->|"activates"| Infection
    IL1B -->|"involved in"| Neuroinflammation
    CASP1 -->|"activates"| IL1B

    style IL1B fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1128)

Target	Relation	Type	Str
Innate Immune Memory	associated_with	process	0.95
Inflammation	activates	disease	0.95
neuroinflammation	promotes	process	0.92
MICROGLIA	expressed_in	cell_type	0.90
NLRP3	associated_with	protein	0.90
inflammatory diseases	causes	disease	0.90
MMP	activates	enzyme	0.90
neuroinflammation	drives	process	0.90
Cardiac Dysfunction	mediates	phenotype	0.90
myeloid cell immune response	activates	process	0.90
Epigenetic Changes	regulates	mechanism	0.90
caspase-1	part_of	protein	0.90
Neuroinflammation	mediates	process	0.90
neuroinflammation	mediates	process	0.90
Myeloid Cell Immune Response	involved_in	process	0.90
Parkinson's Disease	promotes	disease	0.90
Pyroptosis	mediates	process	0.90
Autophagy	activates	pathway	0.90
inflammation	mediates	process	0.88
inflammatory activation	mediates	process	0.88
Parkinson'S Disease	contributes_to	disease	0.87
Vascular Remodelling	contributes_to	process	0.85
Staphylococcus Aureus Infection	involved_in	disease	0.85
Sepsis-Associated Encephalopathy	contributes_to	disease	0.85
Retinal dysfunction	contributes_to	phenotype	0.85
Comorbidities	contributes_to	phenotype	0.85
Infection	activates	disease	0.85
Myeloid Cell Immune Response	mediates	process	0.85
Neuroinflammation	involved_in	process	0.85
POEMS Syndrome	involved_in	disease	0.85
Staphylococcus Aureus Infection	mediates	disease	0.85
Als	activates	disease	0.85
MMP9	upregulates	protein	0.85
Retinal Ganglion Cell Dysfunction	causes	phenotype	0.82
Spinal Cord Injury	contributes_to	disease	0.80
Osteoclast Differentiation	regulates	process	0.80
TNF Signaling Pathway	involved_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
TLR4	associated_with	gene	0.80
autophagy pathway	participates_in	pathway	0.80
HSV-1	regulates	entity	0.80
apoptosis pathway	participates_in	pathway	0.80
MAPT	associated_with	gene	0.80
TREM-1	part_of	protein	0.80
spinal cord injury inflammation	mediates	process	0.80
Pyroptosis	product_of	process	0.80
NF-kB signaling	participates_in	pathway	0.80
TNFA	associated_with	gene	0.80
pyroptosis	participates_in	pathway	0.80

Incoming (700)

Source	Relation	Type	Str
Berberine	inhibits	compound	0.95
Safranal	downregulates	compound	0.95
Spike Protein 1	upregulates	protein	0.95
Cyclosporine A	upregulates	drug	0.92
Nlrp3 Inflammasome	upregulates	pathway	0.92
Lapiferin	downregulates	compound	0.92
NLRP3	upregulates	protein	0.91
Betulinic Acid	downregulates	compound	0.90
h-var-adfecef68a	targets_gene	hypothesis	0.90
h-var-6957745fea	targets_gene	hypothesis	0.90
h-var-08a4d5c07a	targets_gene	hypothesis	0.90
h-var-a0933e666d	targets_gene	hypothesis	0.90
high glucose	upregulates	compound	0.90
INFLAMMASOME COMPLEX	associated_with	protein	0.90
h-var-af9eb8e59b	targets_gene	hypothesis	0.90
h-var-d04a952932	targets_gene	hypothesis	0.90
Litebamine	downregulates	compound	0.90
GS-1	downregulates	compound	0.90
h-cc1076c1	targets	hypothesis	0.90
AMS-17	downregulates	drug	0.90
Itaconate	downregulates	compound	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
Caspase-1	cleaves	protein	0.90
microglia	upregulates	cell_type	0.90
NLRP3/caspase-1/GSDMD	upregulates	pathway	0.90
Ric	downregulates	process	0.90
h-e7e1f943	targets	hypothesis	0.90
Gallic Acid	downregulates	compound	0.90
Hearing Loss	upregulates	phenotype	0.90
NLRP3 Inflammasome	upregulates	pathway	0.90
Mbdnf@Αitgev	downregulates	compound	0.90
Ginsenoside Re	downregulates	compound	0.90
TNF	activates	gene	0.90
NLRP3 inflammasome	activates	pathway	0.88
Microglia	expressed_in	cell_type	0.88
NF-κB Signaling	upregulates	pathway	0.88
Kaempferol	downregulates	compound	0.88
NFKB2	regulates	gene	0.87
Glucose	upregulates	compound	0.85
STING	upregulates	protein	0.85
Irisin	downregulates	protein	0.85
pyroptosis	promotes	process	0.85
NLRP3	regulates	protein	0.85
Guhan Yangsheng Jing	inhibits	drug	0.85
IL17	upregulates	pathway	0.85
ROS overproduction	upregulates	process	0.85
Nlrp3 Inflammasome	activates	process	0.85
NLRP3 Inflammasome	activates	process	0.85
kaempferol	downregulates	compound	0.85
Ams-17	downregulates	compound	0.85

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Peripheral-to-Central Inflammation Circuit Breaker	0.626	-	Blood-brain barrier tight junction disru

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning IL1B in their description or question text

No additional research found