gene

SEL1L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SEL1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

9Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for SEL1L - SEL1L E3 Ubiquitin Protein Ligase

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🧬 Gene Info

Gene Symbol	SEL1L
Full Name	SEL1L E3 Ubiquitin Protein Ligase
Aliases	Page for SEL1L
Chromosome	14p31.1
Protein Type	Reductase
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	90 kDa
Amino Acids	794 aa
Pathways	Er Stress
UniProt ID	Q9UHD2
NCBI Gene ID	6400
Ensembl ID	ENSG00000140451
GeneCards	SEL1L
Human Protein Atlas	SEL1L
Associated Diseases	Aging, Atherosclerosis
Interactions	ATF4, EIF2AK3, ERN1, HSPA5, MITOCHONDRIAL DYSFUNCTION, TIMM17B
KG Connections	10 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SEL1L — AlphaFold Q9UHD2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SEL1L["SEL1L"]
    Aging{"Aging"}
    SEL1L -->|"associated with"| Aging
    Atherosclerosis{"Atherosclerosis"}
    SEL1L -->|"associated with"| Atherosclerosis
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    SEL1L -->|"activates"| MITOCHONDRIAL_DYSFUNCTION
    TIMM17B["TIMM17B"]
    SEL1L -->|"activates"| TIMM17B
    EIF2AK3["EIF2AK3"]
    SEL1L -->|"activates"| EIF2AK3
    ERN1["ERN1"]
    SEL1L -->|"activates"| ERN1
    ATF4["ATF4"]
    SEL1L -->|"activates"| ATF4
    HSPA5["HSPA5"]
    SEL1L -->|"activates"| HSPA5
    Er_Stress(["Er Stress"])
    SEL1L -->|"activates"| Er_Stress
    neurodegeneration["neurodegeneration"]
    SEL1L -->|"implicated in"| neurodegeneration
    AGING["AGING"]
    AGING -->|"associated with"| SEL1L
    style SEL1L fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
Aging	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
Er Stress	activates	pathway	0.60
TIMM17B	activates	gene	0.60
EIF2AK3	activates	gene	0.60
ERN1	activates	gene	0.60
ATF4	activates	gene	0.60
HSPA5	activates	gene	0.60

Incoming (1)

Source	Relation	Type	Str
AGING	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SEL1L in their description or question text

No additional research found