gene

TXN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TXN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

128Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

TXN is a gene implicated in neurodegeneration research. Key relationships include: regulates, biomarker for, associated with. Associated with Als, Ms, Sepsis. Connected to 26 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TXN
Full Name	Thioredoxin
Chromosome	9q31.3
Protein Type	Gene
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	reactive astrocytes - Oligodendrocytes: Important for myelin maintenance - Microglia: Upregulated i
Molecular Weight	12 kDa
Pathways	NF-κB
UniProt ID	P10599
NCBI Gene ID	7295
Ensembl ID	ENSG00000136810
GeneCards	TXN
Human Protein Atlas	TXN
Active Site	Cys-Gly-Pro-Cys motif mediates redox reactions
Reducing Power	Uses NADPH via TXNRD to maintain reduced state
Associated Diseases	ALS, Alzheimer
Interactions	AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMBRA1, ATM, ATP
KG Connections	128 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TXN — AlphaFold P10599 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TXN["TXN"]
    Als{"Als"}
    TXN -->|"expressed in"| Als
    Ms{"Ms"}
    TXN -->|"expressed in"| Ms
    TXN -->|"biomarker for"| Ms
    AP2B1["AP2B1"]
    TXN -->|"associated with"| AP2B1
    GRB2["GRB2"]
    TXN -->|"associated with"| GRB2
    PRDX2["PRDX2"]
    TXN -->|"associated with"| PRDX2
    PIK3C3["PIK3C3"]
    TXN -->|"associated with"| PIK3C3
    Ferroptosis(["Ferroptosis"])
    TXN -->|"biomarker for"| Ferroptosis
    MICRORNAS["MICRORNAS"]
    TXN -->|"regulates"| MICRORNAS
    APOPTOSIS["APOPTOSIS"]
    TXN -->|"therapeutic target"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    TXN -->|"therapeutic target"| Apoptosis
    neurodegeneration["neurodegeneration"]
    TXN -->|"implicated in"| neurodegeneration
    NR3C1["NR3C1"]
    NR3C1 -->|"associated with"| TXN
    FERROPTOSIS["FERROPTOSIS"]
    FERROPTOSIS -->|"biomarker for"| TXN
    ATM["ATM"]
    ATM -->|"interacts with"| TXN
    MIRNAS["MIRNAS"]
    MIRNAS -->|"regulates"| TXN
    G6PD["G6PD"]
    G6PD -->|"therapeutic target"| TXN
    style TXN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (66)

Target	Relation	Type	Str
Ms	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Diabetes	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Sepsis	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ms	biomarker_for	disease	0.65
Mapk	regulates	pathway	0.60
OXIDATIVE STRESS	implicated_in	gene	0.60
GENES	biomarker_for	gene	0.60
IMMUNE INFILTRATION	biomarker_for	gene	0.60
Oxidative Stress	implicated_in	pathway	0.60
Alzheimer	associated_with	disease	0.60
Wnt signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
AP2B1	associated_with	gene	0.60
GRB2	associated_with	gene	0.60
PRDX2	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
SLC2A1	activates	gene	0.60
MEF2C	activates	gene	0.60
NRF2	activates	gene	0.60
Rb	activates	protein	0.60
AGING	activates	gene	0.60
Ras	activates	protein	0.60
DIABETES MELLITUS	expressed_in	gene	0.60
HUB GENES	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
Ferroptosis	biomarker_for	pathway	0.60
MICRORNAS	regulates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
Apoptosis	therapeutic_target	pathway	0.60
HUB GENES	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
VCP	activates	gene	0.60
KRAS	activates	gene	0.60
EXERCISE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
GENES	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60

Incoming (62)

Source	Relation	Type	Str
ATM	interacts_with	gene	0.60
LPL	interacts_with	gene	0.60
CALM1	interacts_with	gene	0.60
GJA1	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
SLC6A1	interacts_with	gene	0.60
NRF2	activates	gene	0.60
SLC2A1	activates	gene	0.60
MEF2C	activates	gene	0.60
GENES	interacts_with	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AGING	activates	gene	0.60
AMBRA1	activates	gene	0.60
BAK1	activates	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
BECN1	activates	gene	0.60
BNIP3	activates	gene	0.60
BNIP3L	activates	gene	0.60
CASP1	activates	gene	0.60
CAT	activates	gene	0.60
CNP	activates	gene	0.60
DNM1L	activates	gene	0.60
DRP1	activates	gene	0.60
FUNDC1	activates	gene	0.60
GSK3B	activates	gene	0.60
GSR	activates	gene	0.60
HIF1A	activates	gene	0.60
HUWE1	activates	gene	0.60
IL1B	activates	gene	0.60
LC3	activates	gene	0.60
MUL1	activates	gene	0.60
NLRP3	activates	gene	0.60
OPA1	activates	gene	0.60
PARL	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
SLC7A11	activates	gene	0.60
SQSTM1	activates	gene	0.60
MIRNAS	regulates	gene	0.60
G6PD	therapeutic_target	gene	0.60
FERROPTOSIS	activates	gene	0.60
FERROPTOSIS	biomarker_for	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
ALZHEIMER	activates	gene	0.60
EXERCISE	activates	gene	0.60
KRAS	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning TXN in their description or question text

No additional research found

TXN

Understanding Entity Pages

Summary

Wiki Pages (21)

TXN — Thioredoxin

ATXN2 Gene

ATXN9 - Ataxin-9

ATXN5 - Ataxin-5

ATXN3 — Ataxin-3

ATXN1 — Ataxin 1

SCA3 — ATXN3 (Ataxin-3)

ATXN10 Protein

ATXN6 - Ataxin-6

ATXN7 — Ataxin-7

TXN2 — Thioredoxin 2

ATXN10 Gene - Ataxin 10

Ataxin-2 (ATXN2)

ATXN8 Gene

Ataxin-7 (ATXN7)

Ataxin-1 (ATXN1)

ATXN2 Protein (Ataxin-2)

Ataxin-3 (ATXN3)

TXNRD1 Protein

TXNDC5 — Thioredoxin Domain Containing 5

TXNRD1 — Thioredoxin Reductase 1