concept

HUB GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUB GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

405Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HUB GENES
Key Genes/Proteins	ACO2, ADCY2, AGING, AIF1, AKT, AKT1
Related Diseases	Aging, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Amyloid

Pathway Diagram

graph TD
    HUB_GENES["HUB GENES"]
    style HUB_GENES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    HUB_GENES -.->|"biomarker for"| Neutrophilic_Inflammation["Neutrophilic Inflammation"]
    HUB_GENES -->|"risk_factor_for"| COPD["COPD"]
    HUB_GENES -->|"involved_in"| Early_Diagnosis_Of_Septic_Card(Early Diagnosis Of Septic Cardiomyopathy)
    HUB_GENES -->|"expressed in"| Alzheimer["Alzheimer"]
    HUB_GENES -->|"expressed in"| Parkinson["Parkinson"]
    HUB_GENES -->|"expressed in"| Multiple_Sclerosis["Multiple Sclerosis"]
    HUB_GENES -->|"activates"| Carcinoma["Carcinoma"]
    HUB_GENES -->|"activates"| Tumor["Tumor"]
    HUB_GENES -->|"activates"| ALS["ALS"]
    HUB_GENES -->|"activates"| Aging["Aging"]
    TP53([TP53]) -->|"regulates"| HUB_GENES
    GENES([GENES]) -->|"regulates"| HUB_GENES
    PARKINSON([PARKINSON]) -->|"expressed in"| HUB_GENES
    ALZHEIMER([ALZHEIMER]) -->|"expressed in"| HUB_GENES
    HSPA1A([HSPA1A]) -->|"regulates"| HUB_GENES
    NEURODEGENERATIVE_DISEASES([NEURODEGENERATIVE DISEASES]) -->|"expressed in"| HUB_GENES
    RNA([RNA]) -->|"expressed in"| HUB_GENES
    CEBPA([CEBPA]) -->|"regulates"| HUB_GENES
    AND([AND]) -->|"regulates"| HUB_GENES
    HSPB1([HSPB1]) -->|"regulates"| HUB_GENES

Outgoing (232)

Target	Relation	Type	Str
Neutrophilic Inflammation	biomarker_for	process	0.92
COPD	risk_factor_for	disease	0.85
Early Diagnosis Of Septic Cardiomyopathy	involved_in	phenotype	0.80
Alzheimer'S Disease	therapeutic_target	disease	0.80
ALS	regulates	disease	0.65
Dementia	regulates	disease	0.65
Parkinson	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Dementia	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
ALS	biomarker_for	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Aging	activates	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Migraine	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Epilepsy	associated_with	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Lewy Body	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Diabetes	associated_with	disease	0.65
Cancer	biomarker_for	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Diabetes	expressed_in	disease	0.65
Alzheimer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Carcinoma	inhibits	disease	0.65
Diabetes	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
SOD2	associated_with	gene	0.60
MMP9	associated_with	gene	0.60

Incoming (173)

Source	Relation	Type	Str
TNF	regulates	gene	0.60
NF-ΚB	associated_with	gene	0.60
MMP9	regulates	gene	0.60
IL-17	associated_with	gene	0.60
TLR2	regulates	gene	0.60
JUN	regulates	gene	0.60
CXCL8	regulates	gene	0.60
IL1B	regulates	gene	0.60
MGA	regulates	gene	0.60
GENES	activates	gene	0.60
TNF	associated_with	gene	0.60
NAMPT	associated_with	gene	0.60
LRPPRC	activates	gene	0.60
GLUD1	activates	gene	0.60
ACO2	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NPY	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CNR2	associated_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
SCN1A	associated_with	gene	0.60
PVALB	associated_with	gene	0.60
TPR	associated_with	gene	0.60
GENES	interacts_with	gene	0.60
CDC42	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
GAP43	associated_with	gene	0.60
CALM1	associated_with	gene	0.60
KIF15	associated_with	gene	0.60
KIF5B	associated_with	gene	0.60
SST	associated_with	gene	0.60
AURKB	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
PYROPTOSIS	associated_with	gene	0.60
SYNAPSE	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
BRD4	activates	gene	0.60
IGF2BP2	activates	gene	0.60
ONCOGENES	activates	gene	0.60
MYH9	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CSF1R	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HUB GENES in their description or question text

No additional research found