concept

HUB GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUB GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

405Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HUB GENES
Key Genes/Proteins	ACO2, ADCY2, AGING, AIF1, AKT, AKT1
Related Diseases	Aging, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Amyloid

Pathway Diagram

graph TD
    HUB_GENES["HUB GENES"]
    style HUB_GENES fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    HUB_GENES -.->|"biomarker for"| Neutrophilic_Inflammation["Neutrophilic Inflammation"]
    HUB_GENES -->|"risk_factor_for"| COPD["COPD"]
    HUB_GENES -->|"involved_in"| Early_Diagnosis_Of_Septic_Card(Early Diagnosis Of Septic Cardiomyopathy)
    HUB_GENES -->|"expressed in"| Alzheimer["Alzheimer"]
    HUB_GENES -->|"expressed in"| Parkinson["Parkinson"]
    HUB_GENES -->|"expressed in"| Multiple_Sclerosis["Multiple Sclerosis"]
    HUB_GENES -->|"activates"| Carcinoma["Carcinoma"]
    HUB_GENES -->|"activates"| Tumor["Tumor"]
    HUB_GENES -->|"activates"| ALS["ALS"]
    HUB_GENES -->|"activates"| Aging["Aging"]
    TP53([TP53]) -->|"regulates"| HUB_GENES
    GENES([GENES]) -->|"regulates"| HUB_GENES
    PARKINSON([PARKINSON]) -->|"expressed in"| HUB_GENES
    ALZHEIMER([ALZHEIMER]) -->|"expressed in"| HUB_GENES
    HSPA1A([HSPA1A]) -->|"regulates"| HUB_GENES
    NEURODEGENERATIVE_DISEASES([NEURODEGENERATIVE DISEASES]) -->|"expressed in"| HUB_GENES
    RNA([RNA]) -->|"expressed in"| HUB_GENES
    CEBPA([CEBPA]) -->|"regulates"| HUB_GENES
    AND([AND]) -->|"regulates"| HUB_GENES
    HSPB1([HSPB1]) -->|"regulates"| HUB_GENES

Outgoing (232)

Target	Relation	Type	Str
Neutrophilic Inflammation	biomarker_for	process	0.92
COPD	risk_factor_for	disease	0.85
Early Diagnosis Of Septic Cardiomyopathy	involved_in	phenotype	0.80
Alzheimer'S Disease	therapeutic_target	disease	0.80
Parkinson	activates	disease	0.65
Tumor	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Migraine	regulates	disease	0.65
Inflammation	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Cancer	biomarker_for	disease	0.65
Stroke	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Dementia	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
ALS	expressed_in	disease	0.65
Cardiovascular	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Carcinoma	inhibits	disease	0.65
ALS	biomarker_for	disease	0.65
Alzheimer	expressed_in	disease	0.65
Parkinson	expressed_in	disease	0.65
Diabetes	expressed_in	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Epilepsy	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Dementia	regulates	disease	0.65
ALS	regulates	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Lewy Body	expressed_in	disease	0.65
Aging	activates	disease	0.65
SLC12A5	biomarker_for	gene	0.60
APOPTOSIS	expressed_in	gene	0.60

Incoming (173)

Source	Relation	Type	Str
TP53	regulates	gene	0.60
GENES	regulates	gene	0.60
PARKINSON	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
HSPA1A	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
CEBPA	regulates	gene	0.60
HSPB1	regulates	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
AGING	associated_with	gene	0.60
TP53	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
MTNR1A	associated_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NPY	associated_with	gene	0.60
C3AR1	associated_with	gene	0.60
CCR5	associated_with	gene	0.60
CXCL8	associated_with	gene	0.60
CNR2	associated_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
EPILEPSY	associated_with	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
EXERCISE	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
NRF2	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
MEF2C	activates	gene	0.60
SLC2A1	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
TXN	activates	gene	0.60
IL6	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
CXCL1	regulates	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
RAC1	regulates	gene	0.60
DENND3	regulates	gene	0.60
PARKINSON	associated_with	gene	0.60
TPM2	regulates	gene	0.60
MET	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
GENES	associated_with	gene	0.60
GBM	associated_with	gene	0.60
LDL	associated_with	gene	0.60
C1QC	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HUB GENES in their description or question text

No additional research found