Contents

Ataxin-2 (ATXN2)

🔬 Protein Info

Gene Symbol	ATXN2
Aliases	Ataxin-2
Chromosome	12q24.12
Function	Translational regulation — Associates with actively translating polysomes
Molecular Weight	140 kDa
Amino Acids	318 aa
Exons	32
Pathways	Apoptosis, Autophagy
GeneCards	ATXN2
Human Protein Atlas	ATXN2
LSm (Like-Sm) domain	mediates RNA binding and protein interactions
LSm-associated domain (LAD)	enhances RNA binding specificity
Polyglutamine tract	CAG repeat region (normal <24; intermediate 24-34; pathogenic SCA2 >34)
PAM2 motif	binds PABPC1 (poly(A)-binding protein)
Associated Diseases	Als, Amyotrophic Lateral Sclerosis, Ataxia, dementia
Known Drugs/Compounds	Antisense Oligonucleotides, levodopa, rapamycin
Interactions	ALS, AND, ATP13A2, ATXN3, C9ORF72, DNA
SciDEX Hypotheses	Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to
KG Connections	329 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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