Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ap2b1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | AP2B1 |
| Full Name | Adaptor Related Protein Complex 2 Subunit Beta 1 |
| Aliases | Beta-2 subunit of AP-2 complex |
| Chromosome | 17q12 |
| Protein Family | AP-2 complex, clathrin adaptors |
| Function | is a heterotetrameric adaptor that recognizes cargo proteins at the plasma membrane and recruits clathrin to form clathrin-coated vesicles. |
| Amino Acids | 937 aa |
| UniProt ID | P63010 |
| NCBI Gene ID | 163 |
| Ensembl ID | ENSG00000091640 |
| OMIM | 601027 |
| GeneCards | AP2B1 |
| Human Protein Atlas | AP2B1 |
| N-terminal trunk | Interactions with other AP-2 subunits |
| Linker region | Flexible connection |
| Associated Diseases | Neurodegeneration, neurodegeneration: |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["AP2B1"]
N1["Als"]
N0 -->|"expressed in"| N1
N2["Ms"]
N0 -->|"expressed in"| N2
N3["GRB2"]
N0 -->|"associated with"| N3
N4["PRDX2"]
N0 -->|"associated with"| N4
N5["PIK3C3"]
N0 -->|"associated with"| N5
N6["NR3C1"]
N6 -->|"associated with"| N0
N7["TXN"]
N7 -->|"associated with"| N0
N8["neurodegeneration"]
N0 -->|"implicated in"| N8
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classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N4 gene
class N5 gene
class N6 gene
class N7 gene| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:AP2B1 | data_in | dataset_row | 0.00 |
| NR3C1 | associated_with | gene | 0.60 |
| TXN | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ap2b1 in their description or question text
No additional research found