gene

CASP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

852Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CASP1 - Caspase 1, key inflammatory caspase regulating pyroptosis, inflammasome activation, and neuroinflammation in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	CASP1
Chromosome	11q22.3
Protein Type	Protease
Target Class	Protease
Function	Small molecule covalent inhibitor of caspase-1 proteolytic activity
Mechanism of Action	Small molecule covalent inhibitor of caspase-1 proteolytic activity
Druggability	Medium (0.46)
Clinical Stage	Phase II
Molecular Weight	45 kDa
Amino Acids	404 aa
Exons	11
Pathways	NF-κB
UniProt ID	A0A8Q3SI00
NCBI Gene ID	842
GeneCards	CASP1
Human Protein Atlas	CASP1
Associated Diseases	Aging, Als, ALZHEIMER, atherosclerosis
Known Drugs/Compounds	KAEMPFEROL, Pterostilbene, rapamycin
Interactions	ACTB, AGING, AIF1, AIM2, AKT3, ALZHEIMER
SciDEX Target	View Target Profile (3 clinical trials)
KG Connections	852 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — CASP1 Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1ICE — X-ray / Cryo-EM

🔮 AI Predicted Structure

A0A8Q3SI00 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CASP1["CASP1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CASP1["CASP1"] -->|"interacts"| NLRP3["NLRP3"]
    CASP1["CASP1"] -->|"interacts"| IL1B["IL1B"]
    CASP1["CASP1"] -->|"interacts"| PYCARD["PYCARD"]
    CASP1["CASP1"] -.->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    CASP1["CASP1"] -.->|"inhibits"| Inflammation["Inflammation"]
    h_e7e1f943["h-e7e1f943"] -->|"therapeutic target"| CASP1["CASP1"]
    NLRP3_1["NLRP3"] -->|"interacts"| CASP1["CASP1"]
    IL1B_2["IL1B"] -->|"interacts"| CASP1["CASP1"]
    PYCARD_3["PYCARD"] -->|"interacts"| CASP1["CASP1"]
    style CASP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (586)

Target	Relation	Type	Str
GSDMD	activates	gene	0.95
IL-1β	activates	protein	0.90
Pyroptosis	associated_with	process	0.90
GSDMD	associated_with	protein	0.90
NLRP3	associated_with	gene	0.90
GSDMD	phosphorylates	protein	0.90
PARKINSON'S DISEASE	biomarker_for	disease	0.88
PANoptosis	mediates	process	0.85
IL18	upregulates	gene	0.85
Tumor	associated_with	disease	0.85
ubiquitin-proteasome	participates_in	pathway	0.80
IL1B	associated_with	gene	0.80
cerebral ischemia-reperfusion injury	contributes_to	disease	0.80
autophagy pathway	participates_in	pathway	0.80
atherosclerosis	causes	disease	0.80
oxidative stress response	participates_in	pathway	0.80
TNF	associated_with	gene	0.80
Neurodegeneration	inhibits	disease	0.75
Inflammation	activates	disease	0.75
CNP	activates	gene	0.70
pyroptosis	participates_in	pathway	0.70
ATG7	associated_with	gene	0.70
IL1B	regulates	gene	0.70
IL18	associated_with	gene	0.70
APOPTOSIS	associated_with	gene	0.70
Inflammasome	activates	pathway	0.70
Apoptosis	associated_with	pathway	0.70
NF-kB signaling	participates_in	pathway	0.70
Autophagy	associated_with	pathway	0.70
Toll-Like Receptor	associated_with	pathway	0.70
PYCARD	interacts_with	gene	0.65
neurodegeneration	associated_with	disease	0.65
NLRP3	interacts_with	gene	0.65
IL1B	interacts_with	gene	0.65
Inflammation	inhibits	disease	0.65
Schizophrenia	activates	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	inhibits	disease	0.65
DOPAMINERGIC	associated_with	cell_type	0.65
TAU	associated_with	gene	0.65
Dementia	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65
INFLAMMASOME	regulates	protein	0.65
ALZHEIMER	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65

Incoming (266)

Source	Relation	Type	Str
QINGQI LIANGYING FORMULA	inhibits	gene	0.95
GS-1	downregulates	compound	0.90
KAEMPFEROL	inhibits	drug	0.90
h-var-adfecef68a	targets_gene	hypothesis	0.90
h-var-a0933e666d	targets_gene	hypothesis	0.90
h-var-af9eb8e59b	targets_gene	hypothesis	0.90
h-var-d04a952932	targets_gene	hypothesis	0.90
h-var-08a4d5c07a	targets_gene	hypothesis	0.90
Pterostilbene	inhibits	compound	0.90
h-e7e1f943	targets	hypothesis	0.90
h-var-6957745fea	targets_gene	hypothesis	0.90
Kaempferol	downregulates	compound	0.88
NLRP3 inflammasome	activates	pathway	0.88
USP22	inhibits	protein	0.85
Nlrp3 Inflammasome	activates	process	0.85
Irisin	downregulates	protein	0.85
GEGEN QINLIAN DECOCTION	downregulates	drug	0.85
TNFR1	activates	gene	0.80
MACROPHAGES	inhibits	cell_type	0.70
AIM2	associated_with	gene	0.70
ATG5	associated_with	gene	0.70
NLRP3	associated_with	gene	0.70
ASC	associated_with	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
LC3	associated_with	gene	0.70
NEURODEGENERATION	inhibits	gene	0.70
PYCARD	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
PYCARD	interacts_with	gene	0.65
IL1B	interacts_with	gene	0.65
NLRP3	interacts_with	gene	0.65
NLRP3 INFLAMMASOME	degrades	pathway	0.65
PYROPTOSIS	degrades	phenotype	0.65
PYROPTOSIS	regulates	phenotype	0.65
NLRP3 INFLAMMASOME	causes	pathway	0.65
ASTROCYTES	activates	cell_type	0.65
ATP	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ALZHEIMER	associated_with	gene	0.60
IL-18	associated_with	gene	0.60
IL1B	inhibits	gene	0.60
AND	expressed_in	gene	0.60
IL6	inhibits	gene	0.60
MARCH7	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
GENES	inhibits	gene	0.60
IL18	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
TNF	associated_with	gene	0.60
DEMENTIA	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.888

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying what are the mechanisms by which gut microbio

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning CASP1 in their description or question text

No additional research found