gene

BAK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

148Connections

0Hypotheses

0Analyses

50Outgoing

35Incoming

0Experiments

0Debates

Summary

BAK1 is a gene implicated in neurodegeneration research. Key relationships include: causes, regulates, activates. Associated with ALS, Aging, Als. Connected to 68 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	BAK1
Full Name	BCL2-Antagonist/Killer 1
Chromosome	6p21.31
Protein Type	BCL2 family (pro-apoptotic)
Function	BAK1 is a 25 kDa protein localized primarily to the mitochondrial outer membrane
Molecular Weight	25 kDa
Pathways	Ferroptosis, Mtor, Necroptosis, Pyroptosis, apoptosis
UniProt ID	Q9YM15
NCBI Gene ID	578
Ensembl ID	ENSG00000130165
GeneCards	BAK1
Human Protein Atlas	BAK1
Mitochondrial Dynamics	Regulation of mitochondrial fission and fusion
[Autophagy](/entities/autophagy)	Selective mitophagy through interaction with autophagy receptors
Cell Cycle Regulation	Checkpoint control in response to DNA damage
Associated Diseases	Als, oxidative stress, OXIDATIVE_STRESS, Tumor
Interactions	AMBRA1, ATP, BAX, BCL2, BECN1, BNIP3
KG Connections	148 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: BAK1 — AlphaFold Q9YM15 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BAK1 Gene

gene · 908 words

→

BAK1 Protein

protein · 844 words

→

Pathway Diagram

graph TD
    BAK1["BAK1"]
    BAK1 -->|"regulates"| Inflammation["Inflammation"]
    BAK1 -.biomarker for.-> Senescence["Senescence"]
    BAK1 -->|"regulates"| Als["Als"]
    BAK1 -->|"regulates"| Aging["Aging"]
    BAK1 -->|"regulates"| Alzheimer["Alzheimer"]
    BAK1 -->|"regulates"| Obesity["Obesity"]
    BAK1 -->|"regulates"| Diabetes["Diabetes"]
    BAK1 -->|"activates"| Tumor["Tumor"]
    BAK1 -->|"regulates"| ALS["ALS"]
    FAS["FAS"] -->|"regulates"| BAK1
    MMP1["MMP1"] -->|"regulates"| BAK1
    GENES["GENES"] -->|"regulates"| BAK1
    BCL2L1["BCL2L1"] -.biomarker for.-> BAK1
    MTOR["MTOR"] -->|"activates"| BAK1
    APOPTOSIS["APOPTOSIS"] -.biomarker for.-> BAK1
    P16INK4A["P16INK4A"] -.biomarker for.-> BAK1
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| BAK1
    P21CIP1["P21CIP1"] -.biomarker for.-> BAK1
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| BAK1

Outgoing (113)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:BAK1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Oxidative Stress	mediates	process	0.90
Mitochondria	participates_in	entity	0.80
Alzheimer	regulates	disease	0.65
Als	activates	disease	0.65
Aging	regulates	disease	0.65
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
Cancer	activates	disease	0.65
Als	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Tumor	causes	disease	0.65
Obesity	regulates	disease	0.65
Tumor	activates	disease	0.65
ALS	causes	disease	0.65
Als	causes	disease	0.65
Senescence	biomarker_for	disease	0.65
Inflammation	regulates	disease	0.65
OXIDATIVE_STRESS	causes	phenotype	0.64
BAX	causes	gene	0.60
DRP1	activates	gene	0.60
BID	causes	gene	0.60
DNM1L	activates	gene	0.60
CNP	activates	gene	0.60
MTOR	activates	gene	0.60
CAT	activates	gene	0.60
FUNDC1	activates	gene	0.60
GSK3B	activates	gene	0.60
GSR	activates	gene	0.60
CASP1	activates	gene	0.60
BID	associated_with	gene	0.60
Apoptosis	biomarker_for	pathway	0.60
BNIP3L	activates	gene	0.60
BNIP3	activates	gene	0.60
MMP1	regulates	gene	0.60
BECN1	activates	gene	0.60
PRKN	activates	gene	0.60
PINK1	activates	gene	0.60
BCL2	activates	gene	0.60
PTEN	activates	gene	0.60
SLC7A11	activates	gene	0.60
SQSTM1	activates	gene	0.60
TXN	activates	gene	0.60
VCP	activates	gene	0.60
BAX	associated_with	gene	0.60
PARL	activates	gene	0.60
OPA1	activates	gene	0.60
BAX	activates	gene	0.60
NLRP3	activates	gene	0.60

Incoming (35)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:BAK1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
BAX	activates	gene	0.60
OPA1	activates	gene	0.60
OMA1	regulates	gene	0.60
P16INK4A	biomarker_for	gene	0.60
ALZHEIMER	regulates	gene	0.60
P21CIP1	biomarker_for	gene	0.60
INFLAMMATION	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.60
OXIDATIVE STRESS	causes	gene	0.60
MITOCHONDRIA	causes	gene	0.60
FERROPTOSIS	causes	gene	0.60
PYROPTOSIS	causes	gene	0.60
P53	activates	gene	0.60
CANCER	activates	gene	0.60
AGING	regulates	gene	0.60
AMBRA1	activates	gene	0.60
GENES	regulates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
ATP	activates	gene	0.60
FAS	regulates	gene	0.60
MMP1	regulates	gene	0.60
BID	associated_with	gene	0.60
BCL2L1	biomarker_for	gene	0.60
MTOR	activates	gene	0.60
BAX	associated_with	gene	0.60
BAX	causes	gene	0.60
MTOR	causes	gene	0.60
BID	causes	gene	0.60
MITOCHONDRIA	associated_with	cell_type	0.50
AMBRA1	co_expressed_with	protein	0.50
BCL2L1	regulates	gene	0.50
ISCHEMIA	associated_with	disease	0.50
ATP	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BAK1 in their description or question text

No additional research found