concept

GSH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

844Connections

2Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	GSH
Key Genes/Proteins	ACHE, ACSL4, ACTB, Actin, Akt, AKT
Related Diseases	Aging, Als, ALS, Alzheimer
Linked Hypotheses	2 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

SGSH Gene

gene · 606 words

→

Pathway Diagram

graph TD
    GSH["GSH"]
    GSH -->|"activates"| GPX4["GPX4"]
    GSH -->|"involved_in"| Redox_Homeostasis["Redox Homeostasis"]
    GSH -->|"expressed in"| Retinal_Ganglion_Cell["Retinal Ganglion Cell"]
    GSH -->|"activates"| ROS["ROS"]
    GSH -->|"inhibits"| NEURON["NEURON"]
    GSH -->|"activates"| SLC7A11["SLC7A11"]
    GSH -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| GSH
    NRF2["NRF2"] -->|"regulates"| GSH
    APOPTOSIS["APOPTOSIS"] -->|"activates"| GSH
    GPX4 -->|"inhibits"| GSH
    CATALASE["CATALASE"] -->|"interacts"| GSH
    GLIOSIS["GLIOSIS"] -->|"activates"| GSH
    ACSL4["ACSL4"] -->|"activates"| GSH

Outgoing (509)

Target	Relation	Type	Str
GPX4	activates	protein	0.90
ferroptosis	participates_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
ferroptosis	activates	process	0.80
unfolded protein response	participates_in	pathway	0.80
ROS	inhibits	gene	0.80
neurons	expressed_in	cell_type	0.80
Retinal Ganglion Cell	expressed_in	cell_type	0.75
pyroptosis	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
neurons	regulates	cell_type	0.70
neurons	activates	cell_type	0.70
hippocampus	expressed_in	brain_region	0.70
Als	therapeutic_target	disease	0.65
Pyroptosis	activates	disease	0.65
Glaucoma	causes	disease	0.65
Pyroptosis	biomarker_for	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	causes	disease	0.65
Depression	inhibits	disease	0.65
Hypertension	inhibits	disease	0.65
Neurodegeneration	causes	disease	0.65
Inflammation	causes	disease	0.65
Alzheimer	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Ferroptosis	biomarker_for	disease	0.65
Huntington	activates	disease	0.65
Als	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Inflammation	activates	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Tumor	inhibits	disease	0.65
ALS	protects_against	disease	0.65
Ferroptosis	associated_with	disease	0.65
Aging	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Parkinson	activates	disease	0.65
Als	protects_against	disease	0.65
Diabetes	inhibits	disease	0.65
ALS	inhibits	disease	0.65
ALS	regulates	disease	0.65
Tumor	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Dementia	associated_with	disease	0.65

Incoming (335)

Source	Relation	Type	Str
NRF2	upregulates	protein	0.90
FERROPTOSIS	activates	process	0.80
CAT	associated_with	gene	0.80
ALOX12	expressed_in	gene	0.70
NRF2	regulates	protein	0.64
ALOX5	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
MTOR	activates	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
SCARB2	interacts_with	gene	0.60
GCLC	inhibits	gene	0.60
ARF1	activates	gene	0.60
NRF2	interacts_with	gene	0.60
ROS	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
FERROPTOSIS	associated_with	gene	0.60
APP	inhibits	gene	0.60
COMPLEMENT	activates	gene	0.60
CD8	activates	gene	0.60
TLR4	activates	gene	0.60
TXNIP	activates	gene	0.60
SLC40A1	activates	gene	0.60
ASC	activates	gene	0.60
NLRP3	activates	gene	0.60
JAK1	activates	gene	0.60
PCBP1	activates	gene	0.60
ROS	inhibits	gene	0.60
STAT4	activates	gene	0.60
MYD88	activates	gene	0.60
AKT	activates	gene	0.60
ATG5	activates	gene	0.60
LC3B	activates	gene	0.60
STAT3	activates	gene	0.60
DJ-1	inhibits	gene	0.60
AND	associated_with	gene	0.60
NRF1	activates	gene	0.60
TNF	expressed_in	gene	0.60
INOS	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
TNF-Α	expressed_in	gene	0.60
HSF1	activates	gene	0.60
PARKINSON	activates	gene	0.60
GAIN	activates	gene	0.60
NF-ΚB	activates	gene	0.60
IFN	activates	gene	0.60
IL-6	activates	gene	0.60
IFN-Γ	activates	gene	0.60
TNF	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	View
N-acetylcysteine (NAC) / System Xc⁻ - Mediated GSH Support f	0.760	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GSH in their description or question text

No additional research found