gene

SLC2A1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC2A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

233Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

SLC2A1 encodes GLUT1, the principal glucose transporter at the blood-brain barrier. Critical for brain energy metabolism, GLUT1 dysfunction contributes to Alzheimer's disease, Parkinson's disease, and GLUT1 deficiency syndrome. Essential for neuronal glucose uptake and metabolic homeostasis.

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🧬 Gene Info

Gene Symbol	SLC2A1
Full Name	Glucose Transporter 1 (GLUT1)
Chromosome	1p34.2
Protein Type	Transporter
Function	is a facilitative glucose transporter belonging to the SLC2A family that provides the critical link between systemic glucose supply and cerebral energy metabolism.
Molecular Weight	54 kDa
Amino Acids	492 aa
Exons	10
Pathways	Ferroptosis, Mapk, Oxidative Stress, autophagy pathway, unfolded protein response
UniProt ID	P11166
NCBI Gene ID	6513
Ensembl ID	ENSG00000117394
OMIM	138140
GeneCards	SLC2A1
Human Protein Atlas	SLC2A1
Associated Diseases	Als, Ataxia, Cancer, Carcinoma, Infection, Ms
Interactions	ABCB1, ABCG2, AGING, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX Hypotheses	GLUT1-Mediated Glucose Flux Coefficient as Neuropr
KG Connections	233 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SLC2A1 — AlphaFold P11166 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SLC2A1 Gene

gene · 2479 words

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Pathway Diagram

graph TD
    SLC2A1["SLC2A1"]
    GLUT1["GLUT1"]
    SLC2A1 -->|"encodes"| GLUT1
    Cancer{"Cancer"}
    SLC2A1 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    SLC2A1 -->|"inhibits"| Tumor
    Ms{"Ms"}
    SLC2A1 -->|"therapeutic target"| Ms
    SLC2A1 -->|"associated with"| Ms
    Parkinson{"Parkinson"}
    SLC2A1 -->|"associated with"| Parkinson
    SLC2A1 -->|"associated with"| Cancer
    SLC2A1 -->|"associated with"| Tumor
    Carcinoma{"Carcinoma"}
    SLC2A1 -->|"associated with"| Carcinoma
    Oxidative_Phosphorylation(["Oxidative Phosphorylation"])
    SLC2A1 -->|"inhibits"| Oxidative_Phosphorylation
    Akt(["Akt"])
    SLC2A1 -->|"interacts with"| Akt
    Epigenetic(["Epigenetic"])
    SLC2A1 -->|"associated with"| Epigenetic
    CANCER["CANCER"]
    CANCER -->|"inhibits"| SLC2A1
    RB1["RB1"]
    RB1 -->|"inhibits"| SLC2A1
    PIK3CA["PIK3CA"]
    PIK3CA -->|"interacts with"| SLC2A1
    MMP9["MMP9"]
    MMP9 -->|"interacts with"| SLC2A1
    PPARA["PPARA"]
    PPARA -->|"interacts with"| SLC2A1
    IGF1R["IGF1R"]
    IGF1R -->|"interacts with"| SLC2A1
    RELA["RELA"]
    RELA -->|"interacts with"| SLC2A1
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| SLC2A1
    INSR["INSR"]
    INSR -->|"interacts with"| SLC2A1
    TTR["TTR"]
    TTR -->|"interacts with"| SLC2A1
    PPARG["PPARG"]
    PPARG -->|"interacts with"| SLC2A1
    ESR1["ESR1"]
    ESR1 -->|"interacts with"| SLC2A1
    style SLC2A1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (113)

Target	Relation	Type	Str
glucose uptake	promotes	process	0.90
Glucose Transport	mediates	process	0.85
GLUT1	encodes	protein	0.70
Als	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Parkinson	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Infection	associated_with	disease	0.65
Ataxia	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	activates	disease	0.65
Carcinoma	associated_with	disease	0.65
Cardiovascular	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Cardiomyopathy	inhibits	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Cancer	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
ALS	protects_against	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
ULK1	activates	gene	0.60
Akt	interacts_with	pathway	0.60
MICROGLIA	therapeutic_target	gene	0.60
ERK	therapeutic_target	gene	0.60
PPAR-Γ	activates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
Mapk	activates	pathway	0.60
Sod1	inhibits	pathway	0.60
PPAR	activates	gene	0.60
TXN	activates	gene	0.60
Rb	activates	protein	0.60
IGF1	activates	gene	0.60
CCND1	associated_with	gene	0.60
Nf-Κb	inhibits	pathway	0.60
Apoptosis	inhibits	pathway	0.60
ALZHEIMER	activates	gene	0.60

Incoming (120)

Source	Relation	Type	Str
PI3K/AKT	phosphorylates	pathway	0.90
HIF1A	upregulates	gene	0.90
AKT1	phosphorylates	protein	0.90
AUTOPHAGY	regulates	phenotype	0.65
PDHA1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
PRKAA1	inhibits	gene	0.60
SOD2	protects_against	gene	0.60
SOD1	inhibits	gene	0.60
NLGN2	inhibits	gene	0.60
PSD95	protects_against	gene	0.60
CYCS	inhibits	gene	0.60
CAT	inhibits	gene	0.60
SLC2A2	inhibits	gene	0.60
MYC	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
ENO1	activates	gene	0.60
CREB1	activates	gene	0.60
NBN	associated_with	gene	0.60
TPX2	associated_with	gene	0.60
ATM	associated_with	gene	0.60
NRXN3	inhibits	gene	0.60
ATR	associated_with	gene	0.60
MRE11	associated_with	gene	0.60
SYN1	associated_with	gene	0.60
CHEK1	associated_with	gene	0.60
CHMP6	associated_with	gene	0.60
EIF4EBP1	associated_with	gene	0.60
MMP2	associated_with	gene	0.60
NOX4	associated_with	gene	0.60
MEF2C	activates	gene	0.60
NOX4	interacts_with	gene	0.60
CANCER	inhibits	gene	0.60
HIF1	expressed_in	gene	0.60
ERK	inhibits	gene	0.60
ROS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
GLUT1	regulates	gene	0.60
AMPK	activates	gene	0.60
MDC1	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	protects_against	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
GENES	inhibits	gene	0.60
CREB	protects_against	gene	0.60
GLUT4	protects_against	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
LDHA	activates	gene	0.60
C-MYC	activates	gene	0.60
GENES	activates	gene	0.60
EGFR	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
GLUT1-Mediated Glucose Flux Coefficient as Neuroprotection I	0.685	translational neuroscience	Which metabolic biomarkers can distingui

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

translational neuroscience | 2026-04-04 | 7 hypotheses Top: 0.829

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Which metabolic biomarkers can distinguish therapeutic response from disease pro

closed · Rounds: 4 · Score: 0.92 · 2026-04-04

Related Research

Hypotheses and analyses mentioning SLC2A1 in their description or question text

No additional research found