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gene 3,663 words KG: ATXN2
Contents

ATXN2 Gene

🧬 Gene Info
Gene SymbolATXN2
AliasesAtaxin-2
Chromosome12q24.12
FunctionTranslational regulation — Associates with actively translating polysomes
Molecular Weight140 kDa
Amino Acids318 aa
Exons32
PathwaysApoptosis, Autophagy
GeneCardsATXN2
Human Protein AtlasATXN2
Associated DiseasesAls, Amyotrophic Lateral Sclerosis, Ataxia, dementia
Known Drugs/CompoundsAntisense Oligonucleotides, levodopa, rapamycin
InteractionsALS, AND, ATP13A2, ATXN3, C9ORF72, DNA
SciDEX HypothesesAtaxin-2 Polyglutamine Expansions Hijack G3BP1 to
KG Connections324 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

RNA Granule Nucleation Site Modulation
Score: 0.66Low Complexity Domain Cross-Linking Inhibition
Score: 0.62Liquid-Liquid Phase Separation Modifier Therapy
Score: 0.55Senescent Cell Mitochondrial DNA Release
Score: 0.74Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74Senescence-Associated Myelin Lipid Remodeling
Score: 0.73CYP46A1 Overexpression Gene Therapy
Score: 0.73Phase-Separated Organelle Targeting
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Stress Granule Phase Separation Modulators
Score: 0.72Axonal RNA Transport Reconstitution
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67Mitochondrial RNA Granule Rescue Pathway
Score: 0.66Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
pg 1/2Next →

Related Analyses (8)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedWhat are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

See Also (7)

Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_withApoptosis in Neurodegeneration
entity · KG edge: expressed_inABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: associated_withATP13A2 — ATPase Cation Transporting 13A2
gene · KG edge: activatesAlzheimer Indonesia
institution · KG edge: regulates

Knowledge Graph (12 edges)

ATXN2 associated_with CACNA1A
ATXN2 associated_with CHAT
ATXN2 associated_with FERMT2
ATXN2 associated_with OPTN
ATXN2 associated_with ABCA1
ATXN2 associated_with DPM2
ATXN2 associated_with TBK1
ATXN2 therapeutic_target C9ORF72
CHAT associated_with ATXN2
ATXN2 activates LRRK2

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