gene

MEF2C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MEF2C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

258Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

1Debates

Summary

MEF2C is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, expressed in. Associated with Cancer, Carcinoma, Lung Cancer. Connected to 24 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MEF2C
Full Name	Myocyte Enhancer Factor 2C
Chromosome	5q14.1
Protein Type	Transcription Factor
Function	is a calcium-dependent transcription factor belonging to the MADS (MCM1, Agamous, Deficiens, serum response factor) box family of MEF2 proteins.
Molecular Weight	50 kDa
Exons	15
Pathways	Effect on MEF2C
UniProt ID	Q06413 (MEF2C)
NCBI Gene ID	4208
Ensembl ID	ENSG00000081189
OMIM	600662
GeneCards	MEF2C
Human Protein Atlas	MEF2C
Associated Diseases	aging, Als, Alzheimer, Alzheimer's disease, Cancer
Known Drugs/Compounds	rapamycin
Interactions	ABCA7, ADORA1, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
SciDEX Hypotheses	MEF2C-Dependent Synaptic Gene Regulation
KG Connections	258 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MEF2C — AlphaFold Q06413 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

mef2c

gene · 1929 words

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MEF2C Protein

protein · 1228 words

→

Pathway Diagram

graph TD
    MEF2C["MEF2C"]
    Cancer{"Cancer"}
    MEF2C -->|"activates"| Cancer
    NF2["NF2"]
    MEF2C -->|"activates"| NF2
    FERROPTOSIS["FERROPTOSIS"]
    MEF2C -->|"activates"| FERROPTOSIS
    CANCER["CANCER"]
    MEF2C -->|"activates"| CANCER
    CDH1["CDH1"]
    MEF2C -->|"activates"| CDH1
    Ferroptosis(["Ferroptosis"])
    MEF2C -->|"activates"| Ferroptosis
    AND["AND"]
    MEF2C -->|"regulates"| AND
    Cortex["Cortex"]
    MEF2C -->|"expressed in"| Cortex
    Interneuron["Interneuron"]
    MEF2C -->|"expressed in"| Interneuron
    Neuron["Neuron"]
    MEF2C -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    MEF2C -->|"implicated in"| neurodegeneration
    style MEF2C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (156)

Target	Relation	Type	Str
MIR133A	regulates	gene	0.85
ALS	expressed_in	disease	0.65
Autism	encodes	disease	0.65
Pain	regulates	disease	0.65
Ms	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Melanoma	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Lung Cancer	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Autism	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	associated_with	disease	0.65
ALZHEIMER'S DISEASE	activates	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	associated_with	gene	0.60
SYNAPSE	activates	gene	0.60
AGING	associated_with	gene	0.60
Phagocytosis	activates	pathway	0.60
Microglia	associated_with	cell_type	0.60
EXERCISE	activates	gene	0.60
KRAS	activates	gene	0.60
AGING	activates	gene	0.60
Neurogenesis	activates	pathway	0.60
TAU PATHOLOGY	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
hippocampus	expressed_in	brain_region	0.60
FERROPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
CDH1	activates	gene	0.60
Ferroptosis	activates	pathway	0.60
Tumor Microenvironment	associated_with	pathway	0.60
Stem Cell	associated_with	pathway	0.60
Immunotherapy	associated_with	pathway	0.60
App	regulates	protein	0.60
FERMT2	associated_with	gene	0.60
RIN3	associated_with	gene	0.60
ZCWPW1	associated_with	gene	0.60
NRF2	activates	gene	0.60

Incoming (102)

Source	Relation	Type	Str
CXCL12	associated_with	gene	0.60
FOXM1	causes	gene	0.60
IL6	associated_with	gene	0.60
NR1H3	causes	gene	0.60
RELB	causes	gene	0.60
PLD3	associated_with	gene	0.60
ABCA7	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
PICALM	associated_with	gene	0.60
CR1	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
CD33	associated_with	gene	0.60
NME8	associated_with	gene	0.60
BIN1	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
INPP5D	associated_with	gene	0.60
EPHA1	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CELF1	associated_with	gene	0.60
TXN	activates	gene	0.60
SLC2A1	activates	gene	0.60
Type I interferon	regulates	protein	0.60
brain aging	regulates	process	0.60
ADORA1	activates	gene	0.60
TAU	regulates	gene	0.60
MAPT	activates	gene	0.60
NFKBIA	regulates	gene	0.60
RBFOX2	expressed_in	gene	0.60
NGN1	regulates	gene	0.60
NGN2	regulates	gene	0.60
NRGN	inhibits	gene	0.60
NRF2	activates	gene	0.60
MEF2	activates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENETIC RISK LOCI	regulates	gene	0.60
AND	activates	gene	0.60
AND	regulates	gene	0.60
CANCER	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
rapamycin	targets	drug	0.60
GUCY1B1	expressed_in	gene	0.60
DCC	regulates	gene	0.60
CREB1	expressed_in	gene	0.60
ASTROCYTE	activates	gene	0.60
LCN2	activates	gene	0.60
HDAC4	activates	gene	0.60
NESTIN	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MEF2C-Dependent Synaptic Gene Regulation	0.740	neurodegeneration	What molecular mechanisms mediate HDAC9'

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.740

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Activity-dependent PGC-1α transcriptional program analysis	exploratory	neurodevelopmental disorders	0.800	0.00	mouse cortical neurons	proposed	N/A

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Renin inhibition improved muscular function by alleviating insulin resistance an [PMID:41391695]	Zhang QY, Ding F, Qin XH, Guo YX, Liu Q	Biochem Pharmacol	2026
Regulon Reconstruction Uncovers Novel Deregulated Factors in Alzheimer's Disease [PMID:41729360]	Belém-Souza MV, Barra-Matos G, de Araújo	Mol Neurobiol	2026
Single-cell epigenetic landscape, microenvironment interactions, and gene regula [PMID:41844162]	Zhang Z, Cheng WS, Taniguchi-Ponciano K,	Cell Syst	2026
Biomimetic KeMA hydrogel encapsulating CAP-EVs-MEF2C for inhibiting inflammation [PMID:41998644]	Guan JB, Lin KY, Wang SX, Wang YG, Li LJ	J Nanobiotechnology	2026
PHF2 regulates grip strength via demethylation at the promoter region of the Mef [PMID:42006298]	Fukushima T, Fujioka T, Imai Y, Masubuch	iScience	2026
Emerging therapeutic significance of MEF2C: Structure, function and its implicat [PMID:42012028]	Zhang J, Xie Y, Jiang S, Huang S, Lv H e	Dev Dyn	2026
Regulon Reconstruction Uncovers Novel Deregulated Factors in Alzheimer's Disease [PMID:41729360]	Belém-Souza MV, Barra-Matos G, de Araújo	Molecular neurobiology	2026

Debates (1)

Multi-agent debates referencing this entity

The abstract shows HDAC9 overexpression reduces Aβ deposition and improves synap

closed · Rounds: 4 · Score: 0.71 · 2026-04-16

Related Research

Hypotheses and analyses mentioning MEF2C in their description or question text

No additional research found