| Gene Symbol | ATXN2 |
| Aliases | Ataxin-2 |
| Chromosome | 12q24.12 |
| Function | Translational regulation — Associates with actively translating polysomes |
| Molecular Weight | 140 kDa |
| Amino Acids | 318 aa |
| Exons | 32 |
| Pathways | Apoptosis, Autophagy |
| GeneCards | ATXN2 |
| Human Protein Atlas | ATXN2 |
| N-terminal region | Contains the polyglutamine (polyQ) tract |
| Lsm domain | Like-Sm protein domain for RNA binding |
| PABP-interacting motif 2 (PAM2) | Mediates interaction with poly(A)-binding protein (PABP) |
| C-terminal region | Associated with stress granule localization |
| Associated Diseases | Als, Amyotrophic Lateral Sclerosis, Ataxia, dementia |
| Known Drugs/Compounds | Antisense Oligonucleotides, levodopa, rapamycin |
| Interactions | ALS, AND, ATP13A2, ATXN3, C9ORF72, DNA |
| SciDEX Hypotheses | Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to |
| KG Connections | 329 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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