| Gene Symbol | TXN2 |
| Full Name | Thioredoxin 2 |
| Chromosome | 22q12.3 |
| Protein Type | Oxidoreductase |
| Function | is a mitochondrial member of the thioredoxin family of oxidoreductases that plays a central role in maintaining cellular redox homeostasis[@holmgren1989]. |
| Amino Acids | 60 aa |
| Ensembl ID | ENSG00000100367 |
| GeneCards | TXN2 |
| Human Protein Atlas | TXN2 |
| Thioredoxin domain | Contains the canonical CXXC active site motif (CGPC) |
| Catalytic cysteines | Cys93 and Cys96 for disulfide/dithiol exchange |
| Peroxiredoxin reduction | Regenerates reduced PRDX3 after peroxide reduction |
| Protein disulfide reduction | Reduces oxidized mitochondrial proteins |
| Redox signaling | Controls local H₂O₂ concentrations and redox-sensitive signaling[@arnr2000] |
| TXN2 | Primary electron donor |
| Associated Diseases | neurodegeneration |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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