gene

SLC7A11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLC7A11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1362Connections

3Hypotheses

4Analyses

50Outgoing

50Incoming

1Experiments

4Debates

Summary

SLC7A11 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 649 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SLC7A11
Full Name	Solute Carrier Family 7 Member 11 (xCT)
Chromosome	4q28.3
Protein Type	Transporter
Target Class	Transporter
Function	Small molecule inhibition of cystine/glutamate exchange
Mechanism of Action	Small molecule inhibition of cystine/glutamate exchange
Primary Expression	various brain cell types:
Druggability	Medium (0.55)
Clinical Stage	Approved
Pathways	Akt, Autophagy, Epigenetic, Ferroptosis, Glutathione Biosynthesis
UniProt ID	Q9UPY5
Ensembl ID	ENSG00000155511
GeneCards	SLC7A11
Human Protein Atlas	SLC7A11
Associated Diseases	Als, cancer, Carcinoma
Known Drugs/Compounds	alphaKG, curcumin, CURCUMIN, icariin, kynurenine, NICOTINAMIDE
Interactions	ACETYL-COA, ACSL4, AGING, AKT, ALOX, ALOX12
SciDEX Target	View Target Profile (4 clinical trials)
SciDEX Hypotheses	Microglial xCT/SLC7A11 Selective Inhibition to Red
KG Connections	1362 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SLC7A11 — AlphaFold Q9UPY5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

SLC7A11 Gene - xCT Cystine/Glutamate Antiporter

gene · 809 words

→

xCT Protein - SLC7A11 Cystine/Glutamate Antiporter

protein · 665 words

→

Pathway Diagram

flowchart TD
    SLC7A11(["SLC7A11"])
    ferroptosis("ferroptosis")
    ROS(["ROS"])
    GPX4(["GPX4"])
    FERROPTOSIS(["FERROPTOSIS"])
    Ferroptosis["Ferroptosis"]
    Cancer["Cancer"]
    Als["Als"]
    Tumor["Tumor"]
    P53(["P53"])
    CANCER(["CANCER"])

    SLC7A11 -.->|"inhibits"| ferroptosis
    SLC7A11 -.->|"inhibits"| ROS
    SLC7A11 -->|"regulates"| GPX4
    SLC7A11 -.->|"inhibits"| FERROPTOSIS
    SLC7A11 -->|"activates"| GPX4
    SLC7A11 -->|"activates"| Ferroptosis
    SLC7A11 -.->|"inhibits"| GPX4
    SLC7A11 -.->|"inhibits"| Ferroptosis
    SLC7A11 -->|"activates"| Cancer
    SLC7A11 -->|"activates"| Als
    SLC7A11 -->|"activates"| Tumor
    SLC7A11 -->|"activates"| P53
    SLC7A11 -->|"activates"| FERROPTOSIS
    SLC7A11 -->|"activates"| CANCER
    SLC7A11 -->|"activates"| ROS

    style SLC7A11 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (776)

Target	Relation	Type	Str
Ferroptosis	inhibits	pathway	1.00
FERROPTOSIS	inhibits	phenotype	1.00
GPX4	regulates	protein	1.00
ferroptosis	inhibits	phenotype	1.00
Ferroptosis	activates	pathway	1.00
CANCER	activates	gene	1.00
ROS	activates	gene	1.00
Cancer	activates	disease	1.00
Als	activates	disease	1.00
FERROPTOSIS	activates	gene	1.00
P53	activates	gene	1.00
GPX4	inhibits	gene	1.00
GPX4	activates	gene	1.00
Tumor	activates	disease	1.00
ROS	inhibits	drug	1.00
Liver Inflammation	inhibits	process	0.90
Cystine Import	mediates	process	0.90
Ferroptosis Resistance	mediates	phenotype	0.90
Liver Fibrosis	protects_against	disease	0.90
Ferroptosis Suppression	involved_in	process	0.90
Nonalcoholic Steatohepatitis	protects_against	disease	0.90
unfolded protein response	participates_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.90
Chondrocyte Ferroptosis	inhibits	process	0.90
Alpha-Ketoglutarate	upregulates	compound	0.90
NASH	protects_against	disease	0.90
ferroptosis	participates_in	pathway	0.90
ROS	downregulates	process	0.90
APOPTOSIS	activates	gene	0.90
OXIDATIVE STRESS	inhibits	gene	0.90
Apoptosis	activates	pathway	0.90
FERROPTOSIS	regulates	gene	0.90
NRF2	activates	gene	0.90
Ferroptosis	regulates	pathway	0.90
Tumor Growth	associated_with	phenotype	0.88
Glutathione Biosynthesis	regulates	pathway	0.88
FERROPTOSIS	protects_against	entity	0.88
ferroptosis	protects_against	process	0.88
Kynurenine	associated_with	compound	0.85
Hepatic Stellate Cell Ferroptosis	involved_in	process	0.85
NASH Progression	protects_against	disease	0.85
Ferroptosis	protects_against	process	0.85
Carcinoma	activates	disease	0.85
Tumor	therapeutic_target	disease	0.85
Colorectal Cancer	activates	disease	0.85
Als	therapeutic_target	disease	0.85
Tumor	inhibits	disease	0.85
Als	regulates	disease	0.85
Neurodegeneration	activates	disease	0.85
Cancer	inhibits	disease	0.85

Incoming (586)

Source	Relation	Type	Str
TMEM16F	regulates	gene	1.00
NRF2	upregulates	protein	0.95
STAT6	upregulates	gene	0.95
FOXK2	upregulates	protein	0.95
NFE2L2	upregulates	gene	0.90
Rotenone	downregulates	compound	0.90
GPX4	associated_with	gene	0.90
Klebsiella Pneumoniae	downregulates	disease	0.90
BECN1	inhibits	protein	0.90
h-7957bb2a	targets	hypothesis	0.90
FOXO3	binds	protein	0.85
SIK1	correlates_with	gene	0.85
FOXO3	downregulates	protein	0.85
INTERLEUKIN-1 BETA	downregulates	protein	0.85
Paricalcitol	upregulates	drug	0.85
Klebsiella pneumoniae	downregulates	disease	0.85
ACSL4	associated_with	gene	0.80
GPX4	treats	gene	0.80
TP53	downregulates	entity	0.80
FOXK2	regulates	protein	0.72
Nrf2	regulates	protein	0.72
JNK	upregulates	protein	0.70
JAK2	regulates	protein	0.70
C-JUN	upregulates	protein	0.70
ALOX12	activates	gene	0.70
FERROPTOSIS	associated_with	phenotype	0.70
PI3K	inhibits	gene	0.70
NRF2	interacts_with	gene	0.70
FERROPTOSIS	causes	phenotype	0.65
FOXO3	interacts_with	gene	0.65
HIF1A	regulates	protein	0.64
ETV4	regulates	protein	0.64
kynurenine	interacts_with	drug	0.64
icariin	activates	drug	0.64
STAT6	activates	protein	0.64
c_Jun	regulates	protein	0.64
paricalcitol	activates	drug	0.64
IL1B	inhibits	gene	0.64
OGD_R	inhibits	phenotype	0.64
NAD	inhibits	gene	0.60
FERROPTOSIS	encodes	gene	0.60
STROKE	inhibits	gene	0.60
FER	activates	gene	0.60
XCT	transports	gene	0.60
CHAC1	expressed_in	gene	0.60
JUN	associated_with	gene	0.60
LC3B	phosphorylates	gene	0.60
BCL2	activates	gene	0.60
AND	activates	gene	0.60
XCT	therapeutic_target	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	View
Microglial xCT/SLC7A11 Selective Inhibition to Reduce Non-Ce	0.620	-	Ferroptosis in ALS and motor neuron dise
EP4 Receptor Agonism for SLC7A11 Upregulation	0.550	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Mentioning Analyses (4)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Gandouling protection against brain injury in Wilson's disease via SIR	validation	Hepatolenticular degeneration	0.900	0.00	TX mice (Wilson's disease mode	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning SLC7A11 in their description or question text

No additional research found

SLC7A11

Understanding Entity Pages

Summary

Wiki Pages (2)

SLC7A11 Gene - xCT Cystine/Glutamate Antiporter

xCT Protein - SLC7A11 Cystine/Glutamate Antiporter

Pathway Diagram

Outgoing (776)

Incoming (586)

Targeting Hypotheses (3)

Mentioning Analyses (4)

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

Cell type vulnerability in Alzheimers Disease (SEA-AD transcriptomic data)

Senolytic therapy for age-related neurodegeneration

Experiments (1)

Related Papers (0)

Debates (4)

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

What gene expression changes in the aging mouse brain predict neurodegenerative

What cell types are most vulnerable in Alzheimers Disease based on SEA-AD transc

Related Research