gene

HUWE1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HUWE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

34Outgoing

21Incoming

0Experiments

0Debates

Summary

Page for HUWE1 — HECT E3 Ubiquitin Protein Ligase 1

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🧬 Gene Info

Gene Symbol	HUWE1
Full Name	HECT, UBA and WWE Domain Containing E3 Ubiquitin Protein Ligase 1
Chromosome	Xp11.22
Protein Type	Ligase
Function	It recognizes and ubiquitinates misfolded and damaged proteins for proteasomal degradation, preventing inclusion body formation by rapidly ubiquitinating aggregation-prone species.
Primary Expression	the brain throughout development and adulthood, with complex transcriptional regulation by Myc, E2F, and activity-dependent transcription factors[@zho
Molecular Weight	482 kDa
Amino Acids	374 aa
Exons	85
Pathways	mTOR
UniProt ID	Q7Z6Z7
NCBI Gene ID	10075
Ensembl ID	ENSG00000086758
OMIM	300697
GeneCards	HUWE1
Human Protein Atlas	HUWE1
Associated Diseases	ALS
Interactions	AMBRA1, ATP, BAK1, BAX, BCL2, BECN1
KG Connections	55 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HUWE1 — AlphaFold Q7Z6Z7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HUWE1 — HECT E3 Ubiquitin Protein Ligase 1

gene · 867 words

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HUWE1 Protein

protein · 589 words

→

Pathway Diagram

graph TD
    HUWE1["HUWE1"] -->|"associated_with"| ALS["ALS"]
    HUWE1["HUWE1"] -->|"co_expressed_with"| IL1B["IL1B"]
    HUWE1["HUWE1"] -->|"co_expressed_with"| LC3["LC3"]
    GSR["GSR"] -->|"co_expressed_with"| HUWE1["HUWE1"]
    HIF1A["HIF1A"] -->|"co_expressed_with"| HUWE1["HUWE1"]
    HUWE1["HUWE1"] -->|"implicated_in"| neurodegeneration["neurodegeneration"]
    style HUWE1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
NOX	activates	gene	0.60
CRISPR-Cas	participates_in	pathway	0.60
NLR	activates	gene	0.60
ROS	activates	gene	0.60
IL1B	activates	gene	0.60
LC3	activates	gene	0.60
MUL1	activates	gene	0.60
NLRP3	activates	gene	0.60
OPA1	activates	gene	0.60
PARL	activates	gene	0.60
PINK1	activates	gene	0.60
PRKN	activates	gene	0.60
PTEN	activates	gene	0.60
SLC7A11	activates	gene	0.60
SQSTM1	activates	gene	0.60
TXN	activates	gene	0.60
VCP	activates	gene	0.60
MRAS	activates	gene	0.60
WIPI2	interacts_with	gene	0.60
WIPI2	activates	gene	0.60
WIPI2	regulates	gene	0.60
ALS	associated_with	disease	0.60
NADPH	activates	gene	0.60
NIX	activates	gene	0.60
TRIM25	regulates	gene	0.60
UBE3A	regulates	gene	0.60
VCP	regulates	gene	0.60
Wnt signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
IL1B	co_expressed_with	gene	0.50
LC3	co_expressed_with	protein	0.50

Incoming (21)

Source	Relation	Type	Str
ATP	activates	gene	0.60
AMBRA1	activates	gene	0.60
BAK1	activates	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
BECN1	activates	gene	0.60
BNIP3	activates	gene	0.60
BNIP3L	activates	gene	0.60
CASP1	activates	gene	0.60
CAT	activates	gene	0.60
CNP	activates	gene	0.60
DNM1L	activates	gene	0.60
DRP1	activates	gene	0.60
FUNDC1	activates	gene	0.60
GSK3B	activates	gene	0.60
GSR	activates	gene	0.60
HIF1A	activates	gene	0.60
G6PD	activates	gene	0.60
GSH	activates	gene	0.60
GSR	co_expressed_with	gene	0.50
HIF1A	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HUWE1 in their description or question text

No additional research found