gene

VCP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VCP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

998Connections

3Hypotheses

3Analyses

50Outgoing

50Incoming

11Experiments

4Debates

Summary

VCP is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with AMI, Aging, Als. Connected to 279 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	VCP
Full Name	Valosin Containing Protein
Chromosome	9p13.3
Protein Family	AAA+ ATPase family
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitors of VCP ATPase activity affecting protein quality control
Mechanism of Action	Small molecule inhibitors of VCP ATPase activity affecting protein quality control
Primary Expression	Ubiquitous - Brain, Muscle, Spinal cord
Subcellular Localization	Cytoplasm, nucleus, ER, mitochondria
Druggability	Medium (0.50)
Clinical Stage	Phase I
Molecular Weight	97 kDa
Amino Acids	806 aa
Exons	17
Pathways	Akt, Autophagy, Er Stress, Mitophagy, Ubiquitin-Proteasome
UniProt ID	P55072
Ensembl ID	ENSG00000165280
GeneCards	VCP
Human Protein Atlas	VCP
Associated Diseases	Als, Alzheimer, Alzheimer's Disease, AMI, amyotrophic lateral sclerosis
Known Drugs/Compounds	rapamycin, RAPAMYCIN
Interactions	Actin, AD, AKT, ALPHA-SYNUCLEIN, ALS, ALS-CAUSING MUTATIONS
SciDEX Target	View Target Profile (4 clinical trials)
SciDEX Hypotheses	VCP-Mediated Autophagy Enhancement VCP/p97 ATPase mutations impair extraction of ubiq VCP-Mediated Autophagy Enhancement
KG Connections	998 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — VCP Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

5FTK — X-ray / Cryo-EM

🔮 AI Predicted Structure

P55072 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    VCP["VCP
(Valosin-containing protein)"]
    
    autophagy["VCP-Mediated
Autophagy Enhancement"]
    er_stress["ER Stress
Pathway"]
    tau_prop["Tau Propagation"]
    
    TBK1["TBK1
(TANK-binding kinase 1)"]
    CHMP2B["CHMP2B
(Charged multivesicular
body protein 2B)"]
    
    ALS["Amyotrophic
Lateral Sclerosis"]
    FTD["Frontotemporal
Dementia"]
    dementia["Dementia"]
    neurodegeneration["Neurodegeneration"]
    
    therapeutic["Therapeutic
Target"]
    
    VCP -->|"modulates"| autophagy
    VCP -->|"regulates"| er_stress
    VCP -->|"influences"| tau_prop
    VCP -->|"activates"| TBK1
    VCP -->|"activates"| CHMP2B
    
    VCP -->|"activates"| ALS
    VCP -->|"activates"| FTD
    VCP -->|"activates"| dementia
    VCP -->|"activates"| neurodegeneration
    
    autophagy -->|"dysfunction leads to"| neurodegeneration
    er_stress -->|"contributes to"| neurodegeneration
    tau_prop -->|"promotes"| FTD
    
    TBK1 -->|"regulates"| autophagy
    CHMP2B -->|"involved in"| autophagy
    
    VCP -->|"potential"| therapeutic
    
    style VCP fill:#006494
    style autophagy fill:#1b5e20
    style therapeutic fill:#1b5e20
    style er_stress fill:#ef5350
    style tau_prop fill:#ef5350
    style TBK1 fill:#4a1a6b
    style CHMP2B fill:#4a1a6b
    style ALS fill:#5d4400
    style FTD fill:#5d4400
    style dementia fill:#5d4400
    style neurodegeneration fill:#5d4400

Outgoing (376)

Target	Relation	Type	Str
Immune Dysfunction	causes	phenotype	0.95
Ufmylation	associated_with	mechanism	0.95
Lysosomal Dysfunction	causes	phenotype	0.95
FTD	associated_with	disease	0.95
Autophagy	associated_with	process	0.90
PIK3C3	interacts_with	gene	0.90
ALS/FTD	risk_factor_for	disease	0.90
BECN1	interacts_with	protein	0.88
Rna Stress Granule Function	regulates	process	0.85
Neurological Disorders	implicated_in	disease	0.85
Cancer	implicated_in	disease	0.85
Autophagic Degradation	regulates	process	0.85
Multisystem Proteinopathy	causes	disease	0.85
RPA	degrades	protein	0.85
RAD51	degrades	protein	0.85
OPTN	stabilizes	protein	0.82
BECN1	associated_with	protein	0.80
OPTN	associated_with	gene	0.80
GPNMB	upregulates	gene	0.80
Stress Granule Disassembly	involved_in	process	0.80
RNA Stress Granule	involved_in	process	0.80
Als	associated_with	disease	0.75
TAU	activates	protein	0.70
neurons	expressed_in	cell_type	0.70
mitochondrial function	participates_in	pathway	0.70
stem cells	expressed_in	cell_type	0.70
TAU	interacts_with	protein	0.70
BECN1	stabilizes	gene	0.70
TAU	modifies	protein	0.70
Autophagy	activates	pathway	0.70
ASTROCYTE	affects	cell_type	0.70
VCP-Mediated Autophagy Enhancement	regulates	mechanism	0.70
neurodegeneration	targets	disease	0.70
STROKE	inhibits	disease	0.70
HIPPOCAMPUS	phosphorylates	brain_region	0.70
neurons	activates	cell_type	0.70
HIPPOCAMPUS	causes	brain_region	0.70
AUTOPHAGY	inhibits	phenotype	0.70
Frontotemporal Dementia	regulates	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Ftd	associated_with	disease	0.65
UBIQUITIN-PROTEASOME SYSTEM	degrades	pathway	0.65
FRONTOTEMPORAL DEMENTIA	degrades	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Ftd	causes	disease	0.65
Neuroinflammation	activates	disease	0.65
UBIQUITIN-PROTEASOME SYSTEM	activates	pathway	0.65
Stroke	activates	disease	0.65
Prion	causes	disease	0.65

Incoming (622)

Source	Relation	Type	Str
UFL1	modulates	gene	0.95
SDA-2026-04-02-gap-tau-prop-20260402003221-H004	targets	hypothesis	0.90
Ufmylation	therapeutic_target	mechanism	0.85
FAF2	interacts_with	protein	0.85
h-18a0fcc6	targets	hypothesis	0.80
ATG5	regulates	gene	0.70
FTD	stabilizes	disease	0.70
PINK1	stabilizes	gene	0.70
BIN1	activates	gene	0.70
FTD	expresses	disease	0.70
MOTOR NEURON	causes	cell_type	0.70
FRONTOTEMPORAL DEMENTIA	causes	disease	0.70
ATG7	regulates	gene	0.70
GRN	activates	gene	0.70
GBA	activates	gene	0.70
STING	inhibits	gene	0.70
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.70
STING	stabilizes	gene	0.70
TAU	targets	gene	0.70
STING	causes	gene	0.70
FRONTOTEMPORAL DEMENTIA	expresses	disease	0.70
MOTOR NEURON	interacts_with	cell_type	0.70
NEURONS	causes	cell_type	0.70
AMYOTROPHIC LATERAL SCLEROSIS	expresses	disease	0.70
FTD	associated_with	disease	0.70
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.70
PINK1	degrades	gene	0.70
ASTROCYTE	interacts_with	cell_type	0.70
BECN1	mediates	gene	0.70
NEURONS	stabilizes	cell_type	0.70
NEURONS	protects_against	cell_type	0.70
NEURONS	treats	cell_type	0.70
SCA3	interacts_with	gene	0.70
HSPA8	interacts_with	gene	0.70
RNA	interacts_with	gene	0.70
SQSTM1	regulates	gene	0.70
SQSTM1	interacts_with	gene	0.70
AUTOPHAGY	activates	gene	0.70
MAPT	co_discussed	gene	0.65
NEURONS	activates	cell_type	0.65
C9orf72	co_discussed	concept	0.65
MOTOR NEURON	activates	cell_type	0.65
ALS	causes	disease	0.65
FUS	co_discussed	gene	0.65
JAK	activates	gene	0.65
GRN	co_discussed	gene	0.65
MICROGLIA	protects_against	cell_type	0.65
SNCA	co_discussed	gene	0.65
GSK3B	co_discussed	gene	0.65
LAMP2	associated_with	gene	0.65

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
VCP-Mediated Autophagy Enhancement	0.787	neurodegeneration	Tau propagation mechanisms and therapeut
VCP/p97 ATPase mutations impair extraction of ubiquitinated	0.720	neurodegeneration	What are the neuron-specific effects of
VCP-Mediated Autophagy Enhancement	0.571	Alzheimer's Disease	Tau propagation mechanisms and therapeut

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
Meta-analysis of LRP1 C766T polymorphism and Alzheimer's disease susce	exploratory	Alzheimer's disease	0.950	human patients	proposed	N/A
Autophagy receptor identification for stress granule elimination	exploratory	neurodegenerative diseases	0.900	cultured cells under arsenite	proposed	N/A
Endothelial CD2AP knockdown effects on memory in male mice	validation	Alzheimer's disease	0.900	male mice	proposed	N/A
Amyloid plaque load analysis in triple-mutant mouse brains	exploratory	Alzheimer's disease	0.880	APP/PSEN1/GD3S-/- triple-trans	proposed	N/A
Reelin treatment rescue via ApoER2 in CD2AP mutant mice	validation	Alzheimer's disease	0.870	mice	proposed	N/A
Network Pharmacology Analysis of Shared AD Targets	exploratory	Alzheimer's disease	0.850	Computational network analysis	proposed	N/A
MRI Phenotyping Method Concordance in Serbian AD Cohort	clinical	Alzheimer's disease	0.850	human patients	proposed	N/A
Endothelin-1 receptor A antagonist rescue in male CD2AP mice	validation	Alzheimer's disease	0.850	male mice	proposed	N/A
Endothelin-1 receptor A antagonist rescue experiment	validation	Alzheimer's disease	0.850	mice	proposed	N/A
Neuroimmune modulation and Aβ clearance mechanisms	exploratory	Alzheimer's disease	0.820	Microglia and astrocytes	proposed	N/A
Competing endogenous RNA (ceRNA) network construction	exploratory	Alzheimer's disease	0.750	computational network analysis	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
Gut Microbiota-Derived Tyrosol Alleviates Radiation-Induced Intestinal Injury vi [PMID:41800257]	Jin X, Xue H, Shi X, Zhou Y, Zhang J, Ze	International journal of biolo	2026	0
TMEM259/MEMBRALIN is a non-canonical ER-phagy receptor that associates with MAN1 [PMID:41799849]	Camilleri JM, Zhang J, Wang T, Ahmad I,	Autophagy reports	2026	0
Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clin [PMID:41396614]	Brown CA, Mundada NS, Cousins KAQ, Sadeg	JAMA neurology	2026	0
Membralin Assembles a MAN1B1-VCP Complex to Target Foreign Glycoproteins from th [PMID:41324484]	Zhang J, Lu X, Li S, Wang T, Ahmad I et	Adv Sci (Weinh)	2026	0
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregul [PMID:41325866]	Zhang K, Sun S, Qiu H, Zhao H, Zhao H et	J Ethnopharmacol	2026	0
Evaluation of Copathology and Clinical Trajectories in Individuals With Tau-Clin [PMID:41396614]	Brown CA, Mundada NS, Cousins KAQ, Sadeg	JAMA Neurol	2026	0
Aberrant nuclear pore complex degradation contributes to neurodegeneration in VC [PMID:41475349]	Dubey SK, Chaubey D, Ikenaga C, Lin WW,	Neuron	2026	0
Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017]	Aynaashe A, Kursula P	Amino Acids	2026	0
Genetic Spectrum and Phenotypic Variability in Chinese Patients with Multisystem [PMID:41737544]	Xia X, Chen X, Sun Y, Zhang M, Qiao K et	Degener Neurol Neuromuscul Dis	2026	0
Study of Fecal Microbiota Transplantation Ameliorates Colon Morphology and Micro [PMID:41745910]	Cao X, Zhou L, Ding Y, Ma C, Chen Q et a	Vet Sci	2026	0
Effect of fermented grape pomace on growth performance and intestinal health of [PMID:41749330]	Wang M, Li Q, Guo A, Yue J, Zhang L et a	Anim Microbiome	2026	0
STUB1-VCP/p97 limits PINK1 overaccumulation to safeguard mitophagy and memory. [PMID:41964371]	Lin JY, Huang ZB, Fang EF, Lu G	Autophagy	2026	0
Clinical impact of the Alzheimer's Disease Neuroimaging Initiative: A review of [PMID:41988903]	Kanoria S, Veitch DP, Miller MJ, Aisen P	Alzheimers Dement	2026	0
Inhibition of PGK1 enhances sensitivity to tyrosine kinase inhibitor in T315I-mu [PMID:41909749]	Wang H, Jiang F, Pan A, Jin C, Xue Y, Li	Acta pharmaceutica Sinica. B	2026	0
Diagnostic performance of transcutaneous laryngeal ultrasound for vocal cord par [PMID:41134433]	Luo X, Xiong J, Liang S, Jiang Z, Chen H	Esophagus : official journal o	2026	0
The vital role of p97/valosin-containing protein-mediated degradation pathways i [PMID:41780115]	Phyu SM, Loh JXY, Zhao Y, Ramadan K	Current opinion in cell biolog	2026	0
Aberrant nuclear pore complex degradation contributes to neurodegeneration in VC [PMID:41475349]	Dubey SK, Chaubey D, Ikenaga C, Lin WW,	Neuron	2026	0
Genetic commonalities between rare subtypes of ALS and CMT: insights into molecu [PMID:41621017]	Aynaashe A, Kursula P	Amino acids	2026	0
STUB1-VCP/p97 complex regulates mitophagy via fine-tuning of PINK1 levels. [PMID:41903135]	Lin JY, Huang ZB, Zhang SQ, Wu Y, Cheng	Cell reports	2026	0

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning VCP in their description or question text

No additional research found

VCP

Understanding Entity Pages

Summary

Wiki Pages (10)

VCP — Valosin Containing Protein

VCP→TDP-43→ALS/FTD Causal Chain

VCP (Valosin-Containing Protein)

VCP/p97 (Valosin-Containing Protein)

VCP Protein

VCP Protein (p97)

Pathway Diagram

Outgoing (376)

Incoming (622)

Targeting Hypotheses (3)

Mentioning Analyses (3)

Which specific factors in conditioned medium from healthy astrocytes rescue moto

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

Tau propagation mechanisms and therapeutic interception points

Experiments (11)

Related Papers (20)

Debates (4)

Which specific factors in conditioned medium from healthy astrocytes rescue moto

The study shows VCP-mutant astrocytes exhibit hypoxia response activation withou

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points

Related Research

VCP

Understanding Entity Pages

Summary

Wiki Pages (10)

VCP — Valosin Containing Protein

VCP→TDP-43→ALS/FTD Causal Chain

VCP (Valosin-Containing Protein)

VCP/p97 (Valosin-Containing Protein)

VCP Protein

VCP Protein (p97)

VCP Proteostasis Modulation Therapy for ALS/FTD

VCP-Targeted Therapy

VCP — Valosin-Containing Protein

Valosin-Containing Protein (VCP)

Pathway Diagram

Outgoing (376)

Incoming (622)

Targeting Hypotheses (3)

Mentioning Analyses (3)

Which specific factors in conditioned medium from healthy astrocytes rescue moto

What molecular mechanism causes VCP mutations to trigger aberrant HIF-1α activat

Tau propagation mechanisms and therapeutic interception points

Experiments (11)

Related Papers (20)

Debates (4)

Which specific factors in conditioned medium from healthy astrocytes rescue moto

The study shows VCP-mutant astrocytes exhibit hypoxia response activation withou

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points

Related Research