gene

OXIDATIVE STRESS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OXIDATIVE STRESS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9970Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

OXIDATIVE STRESS is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 3134 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	OXIDATIVE STRESS
Associated Diseases	Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Anxiety
Known Drugs/Compounds	AFMK, CARBIDOPA, CURCUMIN, DAPAGLIFLOZIN, DIMETHYL FUMARATE, DONEPEZIL
Interactions	6-OHDA, ABCD1, ABCD2, ABCD3, ABCG2, ACC
KG Connections	5186 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"associated with"| ALS["ALS"]
        SOD1["SOD1"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        P62["P62"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        AUTOPHAGY["AUTOPHAGY"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        AKT["AKT"] -->|"associated with"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    end
    subgraph Therapeutic["Therapeutic"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Als["Als"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"therapeutic target"| Diabetes["Diabetes"]
    end
    subgraph Signaling["Signaling"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Inflammation["Inflammation"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Autophagy["Autophagy"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Lipid_Metabolism["Lipid Metabolism"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Epigenetic["Epigenetic"]
        OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"regulates"| Oxidative_Stress["Oxidative Stress"]
        AUTOPHAGY_1["AUTOPHAGY"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
        APOPTOSIS["APOPTOSIS"] -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    end
    style OXIDATIVE_STRESS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style ALS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Lipid_Metabolism fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Epigenetic fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Oxidative_Stress fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style SOD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style P62 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style APOPTOSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AKT fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (3896)

Target	Relation	Type	Str
Mitochondrial Function	therapeutic_target	pathway	1.00
Synaptic Plasticity	activates	pathway	1.00
NF-ΚB	activates	gene	1.00
Parkinson	activates	disease	1.00
Aging	associated_with	disease	1.00
Tumor	regulates	disease	1.00
Inflammation	contributes_to	disease	1.00
Mitochondrial Function	inhibits	pathway	1.00
INFLAMMATION	activates	gene	1.00
Oxidative Stress	inhibits	pathway	1.00
Cardiovascular	regulates	disease	1.00
Mitochondrial Function	regulates	pathway	1.00
Neuroinflammation	therapeutic_target	disease	1.00
NRF2	inhibits	gene	1.00
Cardiac	activates	disease	1.00
Als	activates	disease	1.00
Diabetes	regulates	disease	1.00
INFLAMMATION	therapeutic_target	gene	1.00
Oxidative Stress	contributes_to	pathway	1.00
Als	inhibits	disease	1.00
Ischemia	inhibits	disease	1.00
Ferroptosis	activates	pathway	1.00
Als	expressed_in	disease	1.00
APOPTOSIS	activates	gene	1.00
Senescence	associated_with	disease	1.00
BCL-2	activates	gene	1.00
Inflammation	therapeutic_target	disease	1.00
Alzheimer	associated_with	disease	1.00
NRF2	regulates	gene	1.00
Parkinson	therapeutic_target	disease	1.00
Apoptosis	regulates	pathway	1.00
NRF2	associated_with	gene	1.00
Als	associated_with	disease	1.00
ALS	associated_with	gene	1.00
Ischemia	activates	disease	1.00
Autophagy	associated_with	pathway	1.00
AMPK	activates	gene	1.00
Oxidative Stress	associated_with	pathway	1.00
Nf-Κb	activates	pathway	1.00
Inflammation	activates	disease	1.00
Mtor	activates	pathway	1.00
Autophagy	activates	pathway	1.00
Immune Response	activates	pathway	1.00
Apoptosis	activates	pathway	1.00
Mapk	activates	pathway	1.00
HO-1	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
Cancer	therapeutic_target	disease	1.00
Mitophagy	activates	pathway	1.00
Apoptosis	associated_with	pathway	1.00

Incoming (6074)

Source	Relation	Type	Str
APOPTOSIS	contributes_to	gene	1.00
NEURODEGENERATION	activates	gene	1.00
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	1.00
APOPTOSIS	contributes_to	gene	1.00
MITOPHAGY	activates	gene	1.00
TNF-Α	inhibits	gene	1.00
AGING	activates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
APOPTOSIS	inhibits	gene	1.00
ALZHEIMER'S DISEASE	regulates	gene	1.00
OXIDATIVE STRESS	associated_with	gene	1.00
PI3K	activates	gene	1.00
APOPTOSIS	inhibits	gene	1.00
CANCER	therapeutic_target	gene	1.00
KEAP1	activates	gene	1.00
NF-ΚB	inhibits	gene	1.00
APOPTOSIS	activates	gene	1.00
PINK1	activates	gene	1.00
FERROPTOSIS	inhibits	gene	1.00
Cardiovascular	therapeutic_target	disease	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
MITOCHONDRIAL DYSFUNCTION	regulates	gene	1.00
MTOR	activates	gene	1.00
PINK1	activates	gene	1.00
SIRT1	activates	gene	1.00
AKT	activates	gene	1.00
ALZHEIMER'S DISEASE	therapeutic_target	gene	1.00
Cancer	regulates	disease	1.00
Tumor	associated_with	disease	1.00
FERROPTOSIS	activates	gene	1.00
PARKIN	activates	gene	1.00
DNA	associated_with	gene	1.00
Cancer	activates	disease	1.00
Alzheimer	regulates	disease	1.00
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	1.00
DNA	activates	gene	1.00
NRF2	associated_with	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
NRF2	activates	gene	1.00
Als	therapeutic_target	disease	1.00
Als	regulates	disease	1.00
Tumor	therapeutic_target	disease	1.00
GENES	associated_with	gene	1.00
Diabetes	regulates	disease	1.00
AKT	associated_with	gene	1.00
Alzheimer	associated_with	disease	1.00
Neuroinflammation	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Parkinson	associated_with	disease	1.00
NEURODEGENERATION	activates	gene	1.00