gene

LPL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LPL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

246Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

LPL is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with Aging, Als, Alzheimer. Connected to 109 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	LPL
Full Name	Lipoprotein Lipase
Protein Type	Enzyme
Function	Lipoprotein Lipase (LPL) is a key enzyme in lipid metabolism that hydrolyzes triglycerides in circulating lipoproteins, primarily chylomicrons and very-low-density lipoproteins (VLDL).
Primary Expression	neurons (especially in hippocampus and cortex), astrocytes, and microglia - Regional Distribution: High expression i
Pathways	Cholesterol, Glycolysis, Immune Response, Lipid Metabolism, Oxidative Phosphorylation
GeneCards	LPL
Human Protein Atlas	LPL
Brain lipid homeostasis	Providing energy through fatty acid oxidation
Synaptic function	Supporting membrane lipid composition
Myelin maintenance	Delivering lipids for myelin sheath integrity
Neuroprotection	Modulating inflammation and oxidative stress [2]
Brain	LPL is expressed in neurons (especially in hippocampus and cortex), astrocytes, and microglia
Regional Distribution	High expression in the hippocampus, cerebral cortex, and basal ganglia
Upregulation	Induced during demyelination and in response to neuronal injury
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Dementia, Diabetes
Interactions	ADRA2A, ALDH1A2, ALZHEIMER'S DISEASE, AMPK, AND, APOE
KG Connections	246 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LPL — Lipoprotein Lipase

gene · 590 words

→

LPL Protein — Lipoprotein Lipase

protein · 600 words

→

Pathway Diagram

flowchart TD
    LPL["LPL"] -->|"catalyzes"| triglyceride["triglyceride"]
    ANGPTL4["ANGPTL4"] -.->|"inhibits"| LPL["LPL"]
    LPL["LPL"] -->|"associated with"| Diabetes["Diabetes"]
    LPL["LPL"] -->|"associated with"| Als["Als"]
    LPL["LPL"] -->|"associated with"| Aging["Aging"]
    LPL["LPL"] -->|"associated with"| Ms["Ms"]
    LPL["LPL"] -->|"expressed in"| Diabetes["Diabetes"]
    LPL["LPL"] -->|"expressed in"| Als["Als"]
    LPL["LPL"] -->|"expressed in"| Cardiovascular["Cardiovascular"]
    LPL["LPL"] -->|"interacts with"| Ms["Ms"]
    LPL["LPL"] -->|"interacts with"| Cancer["Cancer"]
    LPL["LPL"] -->|"interacts with"| Tumor["Tumor"]
    style LPL fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style triglyceride fill:#5d4400,stroke:#333,color:#e0e0e0
    style ANGPTL4 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiovascular fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (155)

Target	Relation	Type	Str
triglyceride	catalyzes	biological_process	0.80
NEURODEGENERATION	associated_with	process	0.80
Lipid Processing	modulates	process	0.80
lipid processing	regulates	process	0.80
Aβ Clearance	modulates	process	0.80
Aging	associated_with	disease	0.75
Als	associated_with	disease	0.75
oxidative stress response	participates_in	pathway	0.70
Complement	associated_with	pathway	0.70
Alzheimer	expressed_in	disease	0.65
Diabetes	causes	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
Diabetes	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Dementia	associated_with	disease	0.65
ALS	regulates	disease	0.65
Atherosclerosis	protects_against	disease	0.65
Aging	causes	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Ms	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65
Ms	associated_with	disease	0.65
Alzheimer	regulates	disease	0.65
Diabetes	associated_with	disease	0.65
Diabetes	expressed_in	disease	0.65
Als	regulates	disease	0.65
Als	causes	disease	0.65
Als	expressed_in	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Cancer	interacts_with	disease	0.65
CD36	regulates	gene	0.60
SLC6A1	interacts_with	gene	0.60
HMGCR	associated_with	gene	0.60
LRRK2	interacts_with	gene	0.60
TXN	interacts_with	gene	0.60
PPARG	interacts_with	gene	0.60
PPARG	activates	gene	0.60
GJA1	interacts_with	gene	0.60
CALM1	interacts_with	gene	0.60
PPARGC1A	interacts_with	gene	0.60
P2RX1	activates	gene	0.60
PPARG	regulates	gene	0.60
CTSD	associated_with	gene	0.60

Incoming (91)

Source	Relation	Type	Str
CTSD	associated_with	gene	0.70
TREM2	associated_with	gene	0.70
HIF-1Α	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
FGF21	associated_with	gene	0.60
HMOX1	associated_with	gene	0.60
ALDH1A1	therapeutic_target	gene	0.60
GUSB	therapeutic_target	gene	0.60
ABCA1	associated_with	gene	0.60
DHCR24	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
AMPK	regulates	gene	0.60
LDLR	inhibits	gene	0.60
SLC6A1	interacts_with	gene	0.60
TXN	interacts_with	gene	0.60
LRRK2	interacts_with	gene	0.60
PARKIN	regulates	gene	0.60
CD36	regulates	gene	0.60
ACC	expressed_in	gene	0.60
SREBF2	associated_with	gene	0.60
APOE	associated_with	gene	0.60
APP	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
CLU	associated_with	gene	0.60
CR1	associated_with	gene	0.60
SIRT1	inhibits	gene	0.60
CD36	interacts_with	gene	0.60
TREM2	regulates	gene	0.60
ABCA7	regulates	gene	0.60
PPARG	regulates	gene	0.60
APOE4	regulates	gene	0.60
LDLR	regulates	gene	0.60
LC3B	activates	gene	0.60
SREBP2	regulates	gene	0.60
PER	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
TNF-Α	associated_with	gene	0.60
GENES	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PRESENILIN	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AND	regulates	gene	0.60
MICROGLIA	associated_with	gene	0.60
FASN	activates	gene	0.60
NFKBIA	activates	gene	0.60
PGC1A	activates	gene	0.60
PER2	expressed_in	gene	0.60
HK2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Spatial Transcriptomics Analysis of Alzheimer's Disease Brain Regions

neurodegeneration | 2026-04-16 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

How does spatial gene expression in the hippocampus and entorhinal cortex distin

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Do spatial transcriptomic neighborhoods provide sufficient discriminative power

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning LPL in their description or question text

No additional research found