concept

IMMUNE INFILTRATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IMMUNE INFILTRATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

624Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IMMUNE INFILTRATION is a concept in neurodegeneration research. Key relationships include: associated with, therapeutic target, expressed in. Associated with Aging, Als, Alzheimer. Connected to 417 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	IMMUNE INFILTRATION
Key Genes/Proteins	ACO2, AGING, AIM2, AKT, AKT1, ALZHEIMER
Related Diseases	aging, Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity, Akt

Pathway Diagram

graph TD
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"causes"| INFLAMMATION["INFLAMMATION"]
    IMMUNE_INFILTRATION -->|"activates"| Neuropathy["Neuropathy"]
    IMMUNE_INFILTRATION -->|"activates"| Ms["Ms"]
    IMMUNE_INFILTRATION -->|"target for"| Carcinoma["Carcinoma"]
    IMMUNE_INFILTRATION -->|"target for"| Cancer["Cancer"]
    IMMUNE_INFILTRATION -->|"activates"| Tumor["Tumor"]
    MICROGLIA["MICROGLIA"] -->|"activates"| IMMUNE_INFILTRATION
    ASTROCYTES["ASTROCYTES"] -->|"activates"| IMMUNE_INFILTRATION
    BECN1["BECN1"] -->|"activates"| IMMUNE_INFILTRATION
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| IMMUNE_INFILTRATION
    GSDME["GSDME"] -->|"activates"| IMMUNE_INFILTRATION
    CD8["CD8"] -->|"activates"| IMMUNE_INFILTRATION
    MMP9["MMP9"] -->|"regulates"| IMMUNE_INFILTRATION
    GADD45A["GADD45A"] -->|"regulates"| IMMUNE_INFILTRATION

Outgoing (350)

Target	Relation	Type	Str
Septic Cardiomyopathy	contributes_to	disease	0.95
INFLAMMATION	causes	gene	0.90
Als	associated_with	disease	0.85
Cancer	associated_with	disease	0.85
Inflammation	associated_with	disease	0.85
Autophagy	associated_with	pathway	0.80
Cancer	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Tumor	activates	disease	0.75
Tumor	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
Alzheimer	associated_with	disease	0.75
Mapk	biomarker_for	pathway	0.70
Mtor	associated_with	pathway	0.70
Immune Response	therapeutic_target	pathway	0.70
CANCER	associated_with	gene	0.70
Atherosclerosis	associated_with	disease	0.65
Glioma	activates	disease	0.65
Infection	activates	disease	0.65
Als	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Diabetes	associated_with	disease	0.65
Cirrhosis	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Stroke	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Heart Failure	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Tumor	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Carcinoma	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Ischemia	associated_with	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65

Incoming (274)

Source	Relation	Type	Str
INFLAMMATION	associated_with	gene	0.80
GENES	associated_with	gene	0.80
AUTOPHAGY	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
MMP9	associated_with	gene	0.70
ASTROCYTES	activates	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
CALCOCO2	inhibits	gene	0.60
SCARB2	associated_with	gene	0.60
UBE2D1	associated_with	gene	0.60
LGALS1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
CD4	associated_with	gene	0.60
THBS2	expressed_in	gene	0.60
CTSK	expressed_in	gene	0.60
MARCKS	expressed_in	gene	0.60
FOS	interacts_with	gene	0.60
OPA1	associated_with	gene	0.60
CD8	associated_with	gene	0.60
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.60
TAC1	expressed_in	gene	0.60
TMEM173	associated_with	gene	0.60
STING1	associated_with	gene	0.60
TIMP1	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
GATA2	therapeutic_target	gene	0.60
PDGFRB	therapeutic_target	gene	0.60
TXN	biomarker_for	gene	0.60
OXIDATIVE STRESS	biomarker_for	gene	0.60
MAPK14	biomarker_for	gene	0.60
BCL2	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
NF-ΚB	associated_with	gene	0.60
RNA	activates	gene	0.60
HUB GENES	associated_with	gene	0.60
TNF-Α	associated_with	gene	0.60
FEATURE DEGS	associated_with	gene	0.60
BLM	activates	gene	0.60
AKT	activates	gene	0.60
SPP1	associated_with	gene	0.60
GAIN	activates	gene	0.60
MTOR	activates	gene	0.60
PI3K	activates	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	expressed_in	gene	0.60
DHRS4	expressed_in	gene	0.60
ALS	expressed_in	gene	0.60
NEURODEGENERATION	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IMMUNE INFILTRATION in their description or question text

No additional research found