concept

IMMUNE INFILTRATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IMMUNE INFILTRATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

624Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

IMMUNE INFILTRATION is a concept in neurodegeneration research. Key relationships include: associated with, therapeutic target, expressed in. Associated with Aging, Als, Alzheimer. Connected to 417 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	IMMUNE INFILTRATION
Key Genes/Proteins	ACO2, AGING, AIM2, AKT, AKT1, ALZHEIMER
Related Diseases	aging, Aging, Als, ALS, Alzheimer
Related Pathways	Adaptive Immunity, Akt

Pathway Diagram

graph TD
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"causes"| INFLAMMATION["INFLAMMATION"]
    IMMUNE_INFILTRATION -->|"activates"| Neuropathy["Neuropathy"]
    IMMUNE_INFILTRATION -->|"activates"| Ms["Ms"]
    IMMUNE_INFILTRATION -->|"target for"| Carcinoma["Carcinoma"]
    IMMUNE_INFILTRATION -->|"target for"| Cancer["Cancer"]
    IMMUNE_INFILTRATION -->|"activates"| Tumor["Tumor"]
    MICROGLIA["MICROGLIA"] -->|"activates"| IMMUNE_INFILTRATION
    ASTROCYTES["ASTROCYTES"] -->|"activates"| IMMUNE_INFILTRATION
    BECN1["BECN1"] -->|"activates"| IMMUNE_INFILTRATION
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| IMMUNE_INFILTRATION
    GSDME["GSDME"] -->|"activates"| IMMUNE_INFILTRATION
    CD8["CD8"] -->|"activates"| IMMUNE_INFILTRATION
    MMP9["MMP9"] -->|"regulates"| IMMUNE_INFILTRATION
    GADD45A["GADD45A"] -->|"regulates"| IMMUNE_INFILTRATION

Outgoing (350)

Target	Relation	Type	Str
Septic Cardiomyopathy	contributes_to	disease	0.95
INFLAMMATION	causes	gene	0.90
Cancer	associated_with	disease	0.85
Inflammation	associated_with	disease	0.85
Als	associated_with	disease	0.85
Autophagy	associated_with	pathway	0.80
Als	therapeutic_target	disease	0.75
Tumor	associated_with	disease	0.75
Parkinson	associated_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	activates	disease	0.75
Alzheimer	associated_with	disease	0.75
CANCER	associated_with	gene	0.70
Mapk	biomarker_for	pathway	0.70
Mtor	associated_with	pathway	0.70
Immune Response	therapeutic_target	pathway	0.70
Atherosclerosis	biomarker_for	disease	0.65
Ischemia	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Neuropathy	activates	disease	0.65
Autoimmune	therapeutic_target	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
Cancer	inhibits	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Diabetes	biomarker_for	disease	0.65
Cancer	activates	disease	0.65
Ms	interacts_with	disease	0.65
Leukemia	activates	disease	0.65
Cardiovascular	biomarker_for	disease	0.65
Senescence	therapeutic_target	disease	0.65
Fibrosis	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Ms	expressed_in	disease	0.65
Aging	therapeutic_target	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Cirrhosis	associated_with	disease	0.65
Atherosclerosis	expressed_in	disease	0.65

Incoming (274)

Source	Relation	Type	Str
INFLAMMATION	associated_with	gene	0.80
GENES	associated_with	gene	0.80
AUTOPHAGY	associated_with	gene	0.70
ALZHEIMER'S DISEASE	associated_with	gene	0.70
MMP9	associated_with	gene	0.70
ASTROCYTES	activates	gene	0.70
LAMP1	associated_with	gene	0.70
JAK	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
TNF	therapeutic_target	gene	0.60
REL	regulates	gene	0.60
CD8	regulates	gene	0.60
STAT3	regulates	gene	0.60
IL1B	associated_with	gene	0.60
SOD2	associated_with	gene	0.60
MARCKS	associated_with	gene	0.60
MBP	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
TIMP1	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
GENES	activates	gene	0.60
STING	activates	gene	0.60
NDUFS4	associated_with	gene	0.60
HSPE1	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
NSF	biomarker_for	gene	0.60
NEUROINFLAMMATION	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
TIMMDC1	therapeutic_target	gene	0.60
GENES	expressed_in	gene	0.60
HER2	associated_with	gene	0.60
MITOPHAGY-RELATED GENES	associated_with	gene	0.60
RNA	associated_with	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
LRPPRC	activates	gene	0.60
GLUD1	activates	gene	0.60
ACO2	activates	gene	0.60
HUB GENES	activates	gene	0.60
HSPA9	activates	gene	0.60
ROS	activates	gene	0.60
ATP	activates	gene	0.60
NDUFS1	activates	gene	0.60
NDUFS2	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
CD4	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IMMUNE INFILTRATION in their description or question text

No additional research found