concept

G6PD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about G6PD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

199Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

G6PD is a concept in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Als, Alzheimer, Autoimmune. Connected to 118 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	G6PD
Key Genes/Proteins	ABCA7, ACTB, AKT, ALOX5, AMBRA1, AMPK
Related Diseases	Als, Alzheimer
Related Pathways	Adaptive Immunity, Akt, Apoptosis, apoptosis pathway

Pathway Diagram

graph TD
    G6PD["G6PD"]
    G6PD -->|"encodes"| G6PD_protein["G6PD_protein"]
    G6PD -->|"activates"| Cancer["Cancer"]
    G6PD -->|"activates"| Tumor["Tumor"]
    G6PD -->|"inhibits"| Als["Als"]
    G6PD -->|"activates"| Ms["Ms"]
    G6PD -->|"activates"| Neurodegeneration["Neurodegeneration"]
    G6PD -->|"activates"| Alzheimer["Alzheimer"]
    G6PD -->|"activates"| Neuroinflammation["Neuroinflammation"]
    G6PD -->|"activates"| Inflammation["Inflammation"]
    PTEN["PTEN"] -->|"activates"| G6PD
    PI3K["PI3K"] -->|"activates"| G6PD
    MTOR["MTOR"] -->|"activates"| G6PD
    GENES["GENES"] -->|"activates"| G6PD
    AMPK["AMPK"] -->|"activates"| G6PD
    FASN["FASN"] -->|"activates"| G6PD
    MIRNAS["MIRNAS"] -->|"regulates"| G6PD
    MAVS["MAVS"] -->|"interacts"| G6PD
    AKT["AKT"] -->|"activates"| G6PD
    HIF["HIF"] -->|"activates"| G6PD

Outgoing (143)

Target	Relation	Type	Str
Ferroptosis	associated_with	process	0.85
G6PD_protein	encodes	protein	0.80
Pentose Phosphate Pathway	upregulates	pathway	0.80
Glycolysis	activates	pathway	0.70
Tumor	activates	disease	0.65
Schizophrenia	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Autoimmune	associated_with	disease	0.65
Cancer	activates	disease	0.65
Als	inhibits	disease	0.65
Ms	activates	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Ms	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Inflammation	inhibits	disease	0.65
Neurodegeneration	activates	disease	0.65
Ferroptosis	regulates	disease	0.65
Stroke	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Ms	interacts_with	disease	0.65
Myocardial Infarction	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Fibrosis	associated_with	disease	0.65
Hepatitis	associated_with	disease	0.65
PTEN	activates	gene	0.60
HIF-1Α	activates	gene	0.60
LDHA	activates	gene	0.60
ROS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
GLUT3	activates	gene	0.60
PI3K	activates	gene	0.60
AND	causes	gene	0.60
PKM	activates	gene	0.60
Rb	activates	protein	0.60
Hif-1	activates	protein	0.60
Ras	activates	protein	0.60
GSH	activates	gene	0.60
GSK3B	activates	gene	0.60
GSR	activates	gene	0.60
HIF1A	activates	gene	0.60
HUWE1	activates	gene	0.60

Incoming (56)

Source	Relation	Type	Str
PTEN	activates	gene	0.60
PI3K	activates	gene	0.60
MTOR	activates	gene	0.60
GENES	activates	gene	0.60
SLC7A11	associated_with	gene	0.60
GENES	associated_with	gene	0.60
AKT	associated_with	gene	0.60
AMPK	activates	gene	0.60
FASN	activates	gene	0.60
STROKE	therapeutic_target	gene	0.60
STAT3	regulates	gene	0.60
ALOX5	regulates	gene	0.60
CD8	therapeutic_target	gene	0.60
LGALS3	associated_with	gene	0.60
MIRNAS	regulates	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
MAVS	interacts_with	gene	0.60
OXIDATIVE STRESS	protects_against	gene	0.60
ATP	activates	gene	0.60
GLS	activates	gene	0.60
AMBRA1	activates	gene	0.60
BAK1	activates	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
BECN1	activates	gene	0.60
BNIP3	activates	gene	0.60
BNIP3L	activates	gene	0.60
CASP1	activates	gene	0.60
CAT	activates	gene	0.60
CNP	activates	gene	0.60
DNM1L	activates	gene	0.60
DRP1	activates	gene	0.60
FUNDC1	activates	gene	0.60
HMOX1	associated_with	gene	0.60
IGF1	associated_with	gene	0.60
KIF20A	associated_with	gene	0.60
AKT	activates	gene	0.60
HIF	activates	gene	0.60
HK2	activates	gene	0.60
SRC	activates	gene	0.60
HK1	activates	gene	0.60
CANCER	activates	gene	0.60
PKM	activates	gene	0.60
LDHA	activates	gene	0.60
GLUT1	activates	gene	0.60
AND	activates	gene	0.60
LDHB	activates	gene	0.60
AND	causes	gene	0.60
GLUT3	activates	gene	0.60
ABCA7	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning G6PD in their description or question text

No additional research found