protein

RUBICON

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RUBICON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

0Analyses

43Outgoing

50Incoming

0Experiments

0Debates

Summary

Page for Rubicon Protein

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🔬 Protein Info

Gene Symbol	RUBICON
Molecular Weight	108.8 kDa
Amino Acids	972 aa
Pathways	PI3K
GeneCards	RUBICON
Human Protein Atlas	RUBICON
Interactions	ACTB, AMPK, BECN1, CALCOCO2, CREB, CREBBP
KG Connections	111 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    RUBICON["RUBICON"]
    Epithelial_Cell["Epithelial Cell"]
    RUBICON -->|"associated with"| Epithelial_Cell
    LAMP1["LAMP1"]
    RUBICON -->|"activates"| LAMP1
    RAB7A["RAB7A"]
    RUBICON -->|"activates"| RAB7A
    ISCHEMIA["ISCHEMIA"]
    RUBICON -->|"activates"| ISCHEMIA
    MTORC1["MTORC1"]
    RUBICON -->|"activates"| MTORC1
    Epithelial_Cell["Epithelial Cell"]
    RUBICON -->|"activates"| Epithelial_Cell
    NADH["NADH"]
    RUBICON -->|"activates"| NADH
    INSULIN["INSULIN"]
    RUBICON -->|"activates"| INSULIN
    RAPAMYCIN["RAPAMYCIN"]
    RUBICON -->|"activates"| RAPAMYCIN
    PEROXISOME["PEROXISOME"]
    RUBICON -->|"activates"| PEROXISOME
    HSP70["HSP70"]
    RUBICON -->|"activates"| HSP70
    UBIQUITIN["UBIQUITIN"]
    RUBICON -->|"activates"| UBIQUITIN
    TUMOR_PROTEIN_P53["TUMOR PROTEIN P53"]
    RUBICON -->|"activates"| TUMOR_PROTEIN_P53
    HSC70["HSC70"]
    RUBICON -->|"activates"| HSC70
    PKM2["PKM2"]
    RUBICON -->|"activates"| PKM2
    VPS34["VPS34"]
    RUBICON -->|"activates"| VPS34
    KAT2B["KAT2B"]
    RUBICON -->|"activates"| KAT2B
    TUMOR["TUMOR"]
    RUBICON -->|"activates"| TUMOR
    PARKINSON["PARKINSON"]
    RUBICON -->|"activates"| PARKINSON
    apoptosis["apoptosis"]
    RUBICON -->|"activates"| apoptosis
    AMPK["AMPK"]
    RUBICON -->|"activates"| AMPK
    MAP1LC3["MAP1LC3"]
    RUBICON -->|"activates"| MAP1LC3
    CELL_CYCLE["CELL CYCLE"]
    RUBICON -->|"activates"| CELL_CYCLE
    ACETYL_COA["ACETYL-COA"]
    RUBICON -->|"activates"| ACETYL_COA
    ACAT1["ACAT1"]
    RUBICON -->|"activates"| ACAT1
    Chaperone["Chaperone"]
    RUBICON -->|"activates"| Chaperone
    disease["disease"]
    RUBICON -->|"activates"| disease
    Proteins["Proteins"]
    RUBICON -->|"activates"| Proteins
    GSK3["GSK3"]
    RUBICON -->|"activates"| GSK3
    CHAPERONE_MEDIATED_AUTOPHAGY["CHAPERONE-MEDIATED AUTOPHAGY"]
    RUBICON -->|"activates"| CHAPERONE_MEDIATED_AUTOPHAGY

Outgoing (43)

Target	Relation	Type	Str
Epithelial Cell	associated_with	cell_type	0.50
LAMP1	activates	protein	0.50
RAB7A	activates	protein	0.50
ISCHEMIA	activates	disease	0.50
MTORC1	activates	concept	0.50
Epithelial Cell	activates	cell_type	0.50
NADH	activates	concept	0.50
INSULIN	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
PEROXISOME	activates	concept	0.50
HSP70	activates	protein	0.50
UBIQUITIN	activates	protein	0.50
TUMOR PROTEIN P53	activates	protein	0.50
HSC70	activates	protein	0.50
PKM2	activates	protein	0.50
VPS34	activates	protein	0.50
KAT2B	activates	gene	0.50
TUMOR	activates	disease	0.50
PARKINSON	activates	gene	0.50
apoptosis	activates	process	0.50
AMPK	activates	protein	0.50
MAP1LC3	activates	gene	0.50
CELL CYCLE	activates	cell_type	0.50
ACETYL-COA	activates	concept	0.50
ACAT1	activates	concept	0.50
Chaperone	activates	pathway	0.50
disease	activates	disease	0.50
Proteins	activates	protein	0.50
GSK3	activates	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	activates	concept	0.50
GABARAP	activates	protein	0.50
DNM1L	activates	gene	0.50
LYSOSOME	activates	gene	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
AUTOPHAGOSOME	activates	concept	0.50
PRKAA2	activates	gene	0.50
NFE2L2	activates	gene	0.50
GLP1R	activates	concept	0.50
ACOX1	activates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
Fatty Liver	activates	disease	0.50
NAFLD	activates	disease	0.50
ENDOTHELIAL CELLS	activates	concept	0.50

Incoming (68)

Source	Relation	Type	Str
RUBCN	associated_with	gene	0.50
RUBCN	inhibits	gene	0.50
EGFR	activates	gene	0.50
ACTB	activates	gene	0.50
Autophagy	activates	process	0.50
PPARGC1A	activates	gene	0.50
RPS6	activates	gene	0.50
CTSD	activates	gene	0.50
SQSTM1	activates	gene	0.50
mTOR	activates	entity	0.50
PPARG	activates	gene	0.50
MAP1LC3B	activates	gene	0.50
RPS6KB1	activates	gene	0.50
PPARA	activates	gene	0.50
PIK3C3	activates	gene	0.50
RUBCN	activates	gene	0.50
LRP2	activates	gene	0.50
SREBF1	activates	gene	0.50
EIF4EBP1	activates	gene	0.50
RIBOSOMAL PROTEIN S6	activates	protein	0.50
TFEB	activates	protein	0.50
ULK1	activates	gene	0.50
OPTN	activates	gene	0.50
NDP52	activates	gene	0.50
FIP200	activates	gene	0.50
BECN1	activates	gene	0.50
SNAP29	activates	gene	0.50
WIPI2	activates	gene	0.50
KAT8	activates	gene	0.50
GAPDH	activates	gene	0.50
TP53	activates	gene	0.50
SIRT1	activates	gene	0.50
HDAC6	activates	gene	0.50
CREBBP	activates	gene	0.50
EP300	activates	gene	0.50
LAMP2A	activates	gene	0.50
RB1CC1	activates	gene	0.50
KAT2A	activates	gene	0.50
KAT5	activates	gene	0.50
STX17	activates	gene	0.50
VAMP8	activates	gene	0.50
HSPA8	activates	gene	0.50
CALCOCO2	activates	gene	0.50
NBR1	activates	gene	0.50
CREB	activates	protein	0.50
SNARE	activates	protein	0.50
OPTINEURIN	activates	protein	0.50
GABA	activates	gene	0.50
RAB2A	activates	gene	0.50
GABARAPL1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RUBICON in their description or question text

No additional research found